<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:89ca3651-2025-4869-9188-d871b59244e9,g:d78faf3c-bc1e-45e0-a982-b90ab91b3c2c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="simple" xlink:href="vtrs-20220630.xsd#CondensedConsolidatedStatementsOfOperations"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="extended" id="ica04af5e75154cb697488cac4c6ccfd5_CondensedConsolidatedStatementsOfOperations">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_8524d749-072f-4d4a-868d-eaf252b0eecd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_RevenuesAbstract_8524d749-072f-4d4a-868d-eaf252b0eecd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_385a03b0-2ea0-409b-8d94-f2e527efff9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_8524d749-072f-4d4a-868d-eaf252b0eecd" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_385a03b0-2ea0-409b-8d94-f2e527efff9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_5221bba6-8951-4788-9ea7-52c9d6c6c146" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_8524d749-072f-4d4a-868d-eaf252b0eecd" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_5221bba6-8951-4788-9ea7-52c9d6c6c146" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_3dec8691-70cd-4da2-8807-90f9ed962047" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_8524d749-072f-4d4a-868d-eaf252b0eecd" xlink:to="loc_us-gaap_Revenues_3dec8691-70cd-4da2-8807-90f9ed962047" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_4a804071-854c-40e0-a6e2-80e4d8beaeca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_4a804071-854c-40e0-a6e2-80e4d8beaeca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_2ab9a980-18ff-44e8-8623-d18958f97ae1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_GrossProfit_2ab9a980-18ff-44e8-8623-d18958f97ae1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_15246746-2d7d-4235-a57e-a0bdf5a24607" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_OperatingIncomeLoss_15246746-2d7d-4235-a57e-a0bdf5a24607" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_1f7b2628-3b6e-4b77-8fc7-0f83b955124f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_InterestExpense_1f7b2628-3b6e-4b77-8fc7-0f83b955124f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_3ab085e1-f466-49af-a65f-fe79c7731b8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_3ab085e1-f466-49af-a65f-fe79c7731b8e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bd18db2d-0313-433b-b097-8cd036a3c62e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_bd18db2d-0313-433b-b097-8cd036a3c62e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_c12b6dd9-cd04-4a23-ab17-10aac217fba0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_c12b6dd9-cd04-4a23-ab17-10aac217fba0" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5d941991-84e5-463d-967a-ea2f3ac7370c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_5d941991-84e5-463d-967a-ea2f3ac7370c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_99180f88-1260-4b82-8989-f8f2800ad055" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_99180f88-1260-4b82-8989-f8f2800ad055" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e378bb39-c8ca-4ac9-b5bc-1221b2a668ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_e378bb39-c8ca-4ac9-b5bc-1221b2a668ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_dd930f5a-fcd4-41d8-9c76-fe30b1b4d7b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_dd930f5a-fcd4-41d8-9c76-fe30b1b4d7b4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_a1db25a5-5d87-40bd-a023-89b543ebb610" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_69807157-8fe2-4472-83c1-0ea60707234f" xlink:to="loc_us-gaap_OperatingExpenses_a1db25a5-5d87-40bd-a023-89b543ebb610" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_a10a1e7f-8e28-4063-aace-afe65535a71b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_EarningsPerShareAbstract_a10a1e7f-8e28-4063-aace-afe65535a71b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_0e2854bb-c796-468d-adad-22f78459942e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a10a1e7f-8e28-4063-aace-afe65535a71b" xlink:to="loc_us-gaap_EarningsPerShareBasic_0e2854bb-c796-468d-adad-22f78459942e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_0694acde-8c04-4220-9839-4754678e5e87" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareAbstract_a10a1e7f-8e28-4063-aace-afe65535a71b" xlink:to="loc_us-gaap_EarningsPerShareDiluted_0694acde-8c04-4220-9839-4754678e5e87" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e3188e49-d035-4c47-8bac-08578a125c07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e3188e49-d035-4c47-8bac-08578a125c07" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_73982eaa-d9e6-4a5a-8f34-324af10d6a97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e3188e49-d035-4c47-8bac-08578a125c07" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_73982eaa-d9e6-4a5a-8f34-324af10d6a97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c2aaac9b-0af2-4bd1-a9f8-10c361ccfc52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_e3188e49-d035-4c47-8bac-08578a125c07" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_c2aaac9b-0af2-4bd1-a9f8-10c361ccfc52" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ce51abcb-e21b-491a-a5ea-a99efd61803d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_1bb81a10-ccc0-47aa-8af4-1bc0989f6621" xlink:to="loc_us-gaap_StatementTable_ce51abcb-e21b-491a-a5ea-a99efd61803d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_26c445fb-a8a6-4c44-81bf-118c4cbc831d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ce51abcb-e21b-491a-a5ea-a99efd61803d" xlink:to="loc_srt_ProductOrServiceAxis_26c445fb-a8a6-4c44-81bf-118c4cbc831d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_26c445fb-a8a6-4c44-81bf-118c4cbc831d_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_26c445fb-a8a6-4c44-81bf-118c4cbc831d" xlink:to="loc_srt_ProductsAndServicesDomain_26c445fb-a8a6-4c44-81bf-118c4cbc831d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e0874804-155e-48ae-9319-f6908f0b522e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_26c445fb-a8a6-4c44-81bf-118c4cbc831d" xlink:to="loc_srt_ProductsAndServicesDomain_e0874804-155e-48ae-9319-f6908f0b522e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_dba1680b-4235-45a2-8883-5cd96f4e1bb9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProductAndServiceOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_e0874804-155e-48ae-9319-f6908f0b522e" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_dba1680b-4235-45a2-8883-5cd96f4e1bb9" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfComprehensiveLoss" xlink:type="simple" xlink:href="vtrs-20220630.xsd#CondensedConsolidatedStatementsOfComprehensiveLoss"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfComprehensiveLoss" xlink:type="extended" id="if823d5308d8c4696bb225fa58e6555ec_CondensedConsolidatedStatementsOfComprehensiveLoss">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_68d0955b-cb97-4157-8936-0baff5026c22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_259d95b8-b55f-44ab-b680-d4e6767c241c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_68d0955b-cb97-4157-8936-0baff5026c22" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_259d95b8-b55f-44ab-b680-d4e6767c241c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_68d0955b-cb97-4157-8936-0baff5026c22" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_ad03da54-1520-4ae3-969e-84e3cb35670d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_ad03da54-1520-4ae3-969e-84e3cb35670d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_156ef89e-eea9-4042-b0ef-0994be8cfed8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_156ef89e-eea9-4042-b0ef-0994be8cfed8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_3d5c4815-a0c1-418e-b3c8-7e5e210b3c2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_3d5c4815-a0c1-418e-b3c8-7e5e210b3c2d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent_12a7c8fd-c969-4388-ba7e-5619f0ccd626" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent_12a7c8fd-c969-4388-ba7e-5619f0ccd626" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_f651c70d-251d-43f0-a0e8-8c8e06af7c12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_f651c70d-251d-43f0-a0e8-8c8e06af7c12" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_b120ea88-daf0-4bbf-8ca0-c028076ea077" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_b120ea88-daf0-4bbf-8ca0-c028076ea077" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_d1c04881-500f-41d3-8182-1cecda65ea89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_d1c04881-500f-41d3-8182-1cecda65ea89" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_87658187-6f2c-43e2-a047-b3398ce316cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPeriodIncreaseDecreaseAbstract_e293fc6d-5a48-4440-beae-dd82a24b3240" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_87658187-6f2c-43e2-a047-b3398ce316cb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_e9fa88eb-7322-4034-8524-e769ad4cb736" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_68d0955b-cb97-4157-8936-0baff5026c22" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_e9fa88eb-7322-4034-8524-e769ad4cb736" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_9fe69e7e-5ec1-44cf-bf8d-698279669ca3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_68d0955b-cb97-4157-8936-0baff5026c22" xlink:to="loc_us-gaap_StatementTable_9fe69e7e-5ec1-44cf-bf8d-698279669ca3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_bb1315e3-9544-4633-8e95-bf2f766032b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9fe69e7e-5ec1-44cf-bf8d-698279669ca3" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_bb1315e3-9544-4633-8e95-bf2f766032b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_bb1315e3-9544-4633-8e95-bf2f766032b7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_bb1315e3-9544-4633-8e95-bf2f766032b7" xlink:to="loc_us-gaap_HedgingRelationshipDomain_bb1315e3-9544-4633-8e95-bf2f766032b7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_e858f504-c8c6-45e7-9ebb-5ea7b2f8fc10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_bb1315e3-9544-4633-8e95-bf2f766032b7" xlink:to="loc_us-gaap_HedgingRelationshipDomain_e858f504-c8c6-45e7-9ebb-5ea7b2f8fc10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_1f193756-a5e1-48df-a92f-2fe076d12f09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e858f504-c8c6-45e7-9ebb-5ea7b2f8fc10" xlink:to="loc_us-gaap_CashFlowHedgingMember_1f193756-a5e1-48df-a92f-2fe076d12f09" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_5784ae96-39ec-4417-9b61-71598bf3abf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_e858f504-c8c6-45e7-9ebb-5ea7b2f8fc10" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_5784ae96-39ec-4417-9b61-71598bf3abf0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_eb00f7dd-b062-4e05-881a-5504e58eb80d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9fe69e7e-5ec1-44cf-bf8d-698279669ca3" xlink:to="loc_srt_ConsolidatedEntitiesAxis_eb00f7dd-b062-4e05-881a-5504e58eb80d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_eb00f7dd-b062-4e05-881a-5504e58eb80d_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_eb00f7dd-b062-4e05-881a-5504e58eb80d" xlink:to="loc_srt_ConsolidatedEntitiesDomain_eb00f7dd-b062-4e05-881a-5504e58eb80d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_60236497-11dc-4d60-936f-fe0bcd606eef" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_eb00f7dd-b062-4e05-881a-5504e58eb80d" xlink:to="loc_srt_ConsolidatedEntitiesDomain_60236497-11dc-4d60-936f-fe0bcd606eef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ParentCompanyMember_080e71ad-227f-4a40-a912-4ce788983a8b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ParentCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_60236497-11dc-4d60-936f-fe0bcd606eef" xlink:to="loc_srt_ParentCompanyMember_080e71ad-227f-4a40-a912-4ce788983a8b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="vtrs-20220630.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended" id="i6ced87944fb54282a8ba276adff8bc1a_CondensedConsolidatedBalanceSheetsParenthetical">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_daa81732-1a56-4f9a-ad96-6449abd16207" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_6b43e801-e187-445d-959c-c1cfcad2177a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_daa81732-1a56-4f9a-ad96-6449abd16207" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_6b43e801-e187-445d-959c-c1cfcad2177a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_9bec7819-b9eb-4b79-b445-77107719a941" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_daa81732-1a56-4f9a-ad96-6449abd16207" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_9bec7819-b9eb-4b79-b445-77107719a941" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockShares_503778f5-ec66-486a-bf01-09ffe5ac2fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_daa81732-1a56-4f9a-ad96-6449abd16207" xlink:to="loc_us-gaap_TreasuryStockShares_503778f5-ec66-486a-bf01-09ffe5ac2fc8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_717f4c6d-e0a0-442c-a21a-f078180283c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_daa81732-1a56-4f9a-ad96-6449abd16207" xlink:to="loc_us-gaap_StatementTable_717f4c6d-e0a0-442c-a21a-f078180283c9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_717f4c6d-e0a0-442c-a21a-f078180283c9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2" xlink:to="loc_us-gaap_EquityComponentDomain_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c27c02e4-6a8a-4911-9695-91b66f36631a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_e0b5cde9-42e1-411a-8ca5-4fbe6324a0d2" xlink:to="loc_us-gaap_EquityComponentDomain_c27c02e4-6a8a-4911-9695-91b66f36631a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_af29a12b-4daa-428f-8554-a35540ab8280" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_c27c02e4-6a8a-4911-9695-91b66f36631a" xlink:to="loc_us-gaap_CommonStockMember_af29a12b-4daa-428f-8554-a35540ab8280" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ConsolidatedStatementsofEquity" xlink:type="simple" xlink:href="vtrs-20220630.xsd#ConsolidatedStatementsofEquity"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/ConsolidatedStatementsofEquity" xlink:type="extended" id="i240dee047cc647a89688f6ff52a669d6_ConsolidatedStatementsofEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0df9af89-b7ab-42c8-81a2-5d9d4e8be0cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0df9af89-b7ab-42c8-81a2-5d9d4e8be0cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssued_318a3242-d0d5-4064-8ca1-faf84113e535" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_SharesIssued_318a3242-d0d5-4064-8ca1-faf84113e535" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockShares_e7567e56-a13b-4084-b891-d40d938c0dde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_TreasuryStockShares_e7567e56-a13b-4084-b891-d40d938c0dde" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f106b2bd-271f-4cb0-932b-71f84ed25ce2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f106b2bd-271f-4cb0-932b-71f84ed25ce2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_be4c4725-a7c2-41f1-9fff-0cb265ea69a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_be4c4725-a7c2-41f1-9fff-0cb265ea69a1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_StockIssuedDuringPeriodValueStockOptionsExercisedNetOfSharesTenderedForPayment_b5082d3f-c98f-417b-b391-ea85772e46c9" xlink:href="vtrs-20220630.xsd#vtrs_StockIssuedDuringPeriodValueStockOptionsExercisedNetOfSharesTenderedForPayment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_vtrs_StockIssuedDuringPeriodValueStockOptionsExercisedNetOfSharesTenderedForPayment_b5082d3f-c98f-417b-b391-ea85772e46c9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockValueSharesIssuedNetOfTaxWithholdings_5f87226a-7c1b-481b-8707-c136ef531713" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockValueSharesIssuedNetOfTaxWithholdings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_RestrictedStockValueSharesIssuedNetOfTaxWithholdings_5f87226a-7c1b-481b-8707-c136ef531713" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_e5b61756-981e-412e-8812-af53341167a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_e5b61756-981e-412e-8812-af53341167a0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_30018671-6a94-4301-9516-d66fdff75095" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_30018671-6a94-4301-9516-d66fdff75095" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_5b158f32-796f-4f09-8b9b-a8fdade7d66e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_5b158f32-796f-4f09-8b9b-a8fdade7d66e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_36d634e8-997e-477d-9082-8bfc5da9918b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5a6133cb-8ff7-49ad-b896-49116dcc12ae" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_36d634e8-997e-477d-9082-8bfc5da9918b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_4c212497-dc06-41f1-b7e6-390f13b15e52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssued_2ac13b4e-f34e-4151-8d6e-7995613dc442" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharesIssued"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockShares_5377f348-d5f1-493d-b323-872728fa53c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_6cfe8690-0106-4170-b143-8c1a055694de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:to="loc_us-gaap_DividendsCommonStockCash_6cfe8690-0106-4170-b143-8c1a055694de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_44c4fb80-3ccb-47f9-b174-e91983d1386f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_44c4fb80-3ccb-47f9-b174-e91983d1386f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_4acec972-9e6c-4788-a2ce-cbc14cdb8357" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_4acec972-9e6c-4788-a2ce-cbc14cdb8357" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_97c383b5-0b6c-4880-a5fb-95f541f96375" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_12d53cfd-9a47-4e71-9467-5eb47c79df9a" xlink:to="loc_us-gaap_StatementTable_97c383b5-0b6c-4880-a5fb-95f541f96375" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_927a3544-6695-4c12-8b3e-b94f760d138b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_97c383b5-0b6c-4880-a5fb-95f541f96375" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_927a3544-6695-4c12-8b3e-b94f760d138b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_927a3544-6695-4c12-8b3e-b94f760d138b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_927a3544-6695-4c12-8b3e-b94f760d138b" xlink:to="loc_us-gaap_EquityComponentDomain_927a3544-6695-4c12-8b3e-b94f760d138b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_927a3544-6695-4c12-8b3e-b94f760d138b" xlink:to="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_08555612-8be9-42da-b7f9-9c1c1f1c0074" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:to="loc_us-gaap_CommonStockMember_08555612-8be9-42da-b7f9-9c1c1f1c0074" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_f1234aba-4511-46d1-81c1-46341c6d4419" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_f1234aba-4511-46d1-81c1-46341c6d4419" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_928fe2bd-d040-4ec3-b8da-db6555578736" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:to="loc_us-gaap_RetainedEarningsMember_928fe2bd-d040-4ec3-b8da-db6555578736" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockMember_bd4da3f0-9b84-4684-86c8-decf4a5780c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TreasuryStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:to="loc_us-gaap_TreasuryStockMember_bd4da3f0-9b84-4684-86c8-decf4a5780c2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_b93438dc-555d-41ba-99e3-b641e4e1d46d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_f4fe25b3-c7a2-4fcf-a891-042993694e8f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_b93438dc-555d-41ba-99e3-b641e4e1d46d" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GeneralDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#GeneralDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/GeneralDetails" xlink:type="extended" id="i527fe092d8564311b933bbb8a6fad836_GeneralDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualRiskOrUncertaintyLineItems_a5e1939a-2f4b-4383-b88c-fa53a45cd4e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualRiskOrUncertaintyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PercentOfConsolidatedNetSalesImpactedHighInflationaryEconomy_1c4c14e1-2608-40cd-a742-e510ce6552bd" xlink:href="vtrs-20220630.xsd#vtrs_PercentOfConsolidatedNetSalesImpactedHighInflationaryEconomy"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualRiskOrUncertaintyLineItems_a5e1939a-2f4b-4383-b88c-fa53a45cd4e9" xlink:to="loc_vtrs_PercentOfConsolidatedNetSalesImpactedHighInflationaryEconomy_1c4c14e1-2608-40cd-a742-e510ce6552bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PercentOfTotalAssetsImpactedHighInflationaryEconomy_8b4bace0-0725-436b-877f-a0fe6af6c7ba" xlink:href="vtrs-20220630.xsd#vtrs_PercentOfTotalAssetsImpactedHighInflationaryEconomy"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualRiskOrUncertaintyLineItems_a5e1939a-2f4b-4383-b88c-fa53a45cd4e9" xlink:to="loc_vtrs_PercentOfTotalAssetsImpactedHighInflationaryEconomy_8b4bace0-0725-436b-877f-a0fe6af6c7ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualRiskOrUncertaintyTable_57821a60-cf07-475e-a366-6883e4217a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualRiskOrUncertaintyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_UnusualRiskOrUncertaintyLineItems_a5e1939a-2f4b-4383-b88c-fa53a45cd4e9" xlink:to="loc_us-gaap_UnusualRiskOrUncertaintyTable_57821a60-cf07-475e-a366-6883e4217a8a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnusualRiskOrUncertaintyTable_57821a60-cf07-475e-a366-6883e4217a8a" xlink:to="loc_srt_StatementGeographicalAxis_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2" xlink:to="loc_srt_SegmentGeographicalDomain_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2225040d-6ed0-4646-91e1-c1269ca818a4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_4bf6eac7-f5c9-4d5a-a193-cbcb9204d9c2" xlink:to="loc_srt_SegmentGeographicalDomain_2225040d-6ed0-4646-91e1-c1269ca818a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_TR_e1b8f7d0-a330-41e0-9daa-4c07c84e1df5" xlink:href="https://xbrl.sec.gov/country/2021/country-2021.xsd#country_TR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2225040d-6ed0-4646-91e1-c1269ca818a4" xlink:to="loc_country_TR_e1b8f7d0-a330-41e0-9daa-4c07c84e1df5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemAxis_36689ca8-c04f-4b49-9218-cea0fa09470d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_UnusualRiskOrUncertaintyTable_57821a60-cf07-475e-a366-6883e4217a8a" xlink:to="loc_us-gaap_UnusualOrInfrequentItemAxis_36689ca8-c04f-4b49-9218-cea0fa09470d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_36689ca8-c04f-4b49-9218-cea0fa09470d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_36689ca8-c04f-4b49-9218-cea0fa09470d" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_36689ca8-c04f-4b49-9218-cea0fa09470d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemDomain_7ad0d6c7-5a66-49e8-9455-aec84ae0eccb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_UnusualOrInfrequentItemAxis_36689ca8-c04f-4b49-9218-cea0fa09470d" xlink:to="loc_us-gaap_UnusualOrInfrequentItemDomain_7ad0d6c7-5a66-49e8-9455-aec84ae0eccb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnusualOrInfrequentItemMember_db4a734f-acef-4d29-bae1-889e286f4c14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnusualOrInfrequentItemMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_UnusualOrInfrequentItemDomain_7ad0d6c7-5a66-49e8-9455-aec84ae0eccb" xlink:to="loc_us-gaap_UnusualOrInfrequentItemMember_db4a734f-acef-4d29-bae1-889e286f4c14" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableRevenueDisaggregationTableDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#RevenueRecognitionandAccountsReceivableRevenueDisaggregationTableDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableRevenueDisaggregationTableDetails" xlink:type="extended" id="i4d6e8730595644bd9b75d281b54b64ea_RevenueRecognitionandAccountsReceivableRevenueDisaggregationTableDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_7bd9c9bb-2d8a-4fe6-a464-6f30f9c02399" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ff3c4cc0-54ce-449d-b69a-992f2e87d737" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7bd9c9bb-2d8a-4fe6-a464-6f30f9c02399" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ff3c4cc0-54ce-449d-b69a-992f2e87d737" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_01c685ed-d665-43bc-a6fd-cdae6d240d23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7bd9c9bb-2d8a-4fe6-a464-6f30f9c02399" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_01c685ed-d665-43bc-a6fd-cdae6d240d23" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_ecf62f4a-0448-407e-a0e0-4a34f8375ce3" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01c685ed-d665-43bc-a6fd-cdae6d240d23" xlink:to="loc_srt_ConsolidationItemsAxis_ecf62f4a-0448-407e-a0e0-4a34f8375ce3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_ecf62f4a-0448-407e-a0e0-4a34f8375ce3_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_ecf62f4a-0448-407e-a0e0-4a34f8375ce3" xlink:to="loc_srt_ConsolidationItemsDomain_ecf62f4a-0448-407e-a0e0-4a34f8375ce3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_76805824-2aac-408f-bcc8-2dc2ee265f63" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_ecf62f4a-0448-407e-a0e0-4a34f8375ce3" xlink:to="loc_srt_ConsolidationItemsDomain_76805824-2aac-408f-bcc8-2dc2ee265f63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_159b3257-8ea5-42e8-9583-32708d860a10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_76805824-2aac-408f-bcc8-2dc2ee265f63" xlink:to="loc_us-gaap_OperatingSegmentsMember_159b3257-8ea5-42e8-9583-32708d860a10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_bdd37782-6b36-41a3-88ec-23da9a5f5f63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01c685ed-d665-43bc-a6fd-cdae6d240d23" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_bdd37782-6b36-41a3-88ec-23da9a5f5f63" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_bdd37782-6b36-41a3-88ec-23da9a5f5f63_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_bdd37782-6b36-41a3-88ec-23da9a5f5f63" xlink:to="loc_us-gaap_SegmentDomain_bdd37782-6b36-41a3-88ec-23da9a5f5f63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_bdd37782-6b36-41a3-88ec-23da9a5f5f63" xlink:to="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DevelopedMarketsSegmentMember_1e02e388-852c-4c0b-9529-2c4806cfa842" xlink:href="vtrs-20220630.xsd#vtrs_DevelopedMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:to="loc_vtrs_DevelopedMarketsSegmentMember_1e02e388-852c-4c0b-9529-2c4806cfa842" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GreaterChinaSegmentMember_0873315d-e74a-4924-898e-302b5ce792cb" xlink:href="vtrs-20220630.xsd#vtrs_GreaterChinaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:to="loc_vtrs_GreaterChinaSegmentMember_0873315d-e74a-4924-898e-302b5ce792cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_e217f293-8d44-4b14-9ace-8601bf201e25" xlink:href="vtrs-20220630.xsd#vtrs_JapanAustraliaAndNewZealandSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:to="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_e217f293-8d44-4b14-9ace-8601bf201e25" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EmergingMarketsSegmentMember_25245242-a905-40cf-88af-c137383181d0" xlink:href="vtrs-20220630.xsd#vtrs_EmergingMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_347c6c69-934a-46d3-ae35-e185e46fab59" xlink:to="loc_vtrs_EmergingMarketsSegmentMember_25245242-a905-40cf-88af-c137383181d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_01c685ed-d665-43bc-a6fd-cdae6d240d23" xlink:to="loc_srt_ProductOrServiceAxis_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa" xlink:to="loc_srt_ProductsAndServicesDomain_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_60be24e8-fed1-4ff1-8dd0-eae4f4dc3daa" xlink:to="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BrandsMember_13d6e83c-b633-444c-8aa2-44287eea1a6b" xlink:href="vtrs-20220630.xsd#vtrs_BrandsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_BrandsMember_13d6e83c-b633-444c-8aa2-44287eea1a6b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ComplexGXAndBiosimilarsMember_4d9ba4a6-84b5-4294-9e53-8b0ee51bac1e" xlink:href="vtrs-20220630.xsd#vtrs_ComplexGXAndBiosimilarsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_ComplexGXAndBiosimilarsMember_4d9ba4a6-84b5-4294-9e53-8b0ee51bac1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GenericsMember_1515d265-272d-49c7-851f-3f5d233a3335" xlink:href="vtrs-20220630.xsd#vtrs_GenericsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_GenericsMember_1515d265-272d-49c7-851f-3f5d233a3335" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_LipitorMember_81e55d6d-d478-46b0-b94d-4bf0b707220b" xlink:href="vtrs-20220630.xsd#vtrs_LipitorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_LipitorMember_81e55d6d-d478-46b0-b94d-4bf0b707220b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_NorvascMember_49939ec3-1332-4426-97f4-3edf46a43fef" xlink:href="vtrs-20220630.xsd#vtrs_NorvascMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_NorvascMember_49939ec3-1332-4426-97f4-3edf46a43fef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_LyricaMember_bd0a9139-90ef-4864-9eef-7c6a9217dc78" xlink:href="vtrs-20220630.xsd#vtrs_LyricaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_LyricaMember_bd0a9139-90ef-4864-9eef-7c6a9217dc78" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ViagraMember_496247c7-7e59-4828-a7ba-4a7b8f59f64a" xlink:href="vtrs-20220630.xsd#vtrs_ViagraMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_ViagraMember_496247c7-7e59-4828-a7ba-4a7b8f59f64a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EpiPenAutoInjectorsMember_f6b3d5b5-7386-4e94-980f-0b2c5f3496c3" xlink:href="vtrs-20220630.xsd#vtrs_EpiPenAutoInjectorsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_EpiPenAutoInjectorsMember_f6b3d5b5-7386-4e94-980f-0b2c5f3496c3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CelebrexMember_04ae821c-65ef-4e76-b167-f2ed1299310b" xlink:href="vtrs-20220630.xsd#vtrs_CelebrexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_CelebrexMember_04ae821c-65ef-4e76-b167-f2ed1299310b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EffexorMember_94c43850-96d9-42a6-9dbe-c194c40f719f" xlink:href="vtrs-20220630.xsd#vtrs_EffexorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_EffexorMember_94c43850-96d9-42a6-9dbe-c194c40f719f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ZoloftMember_f9ef9575-8e96-44a4-b743-b7ec3b094f52" xlink:href="vtrs-20220630.xsd#vtrs_ZoloftMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_ZoloftMember_f9ef9575-8e96-44a4-b743-b7ec3b094f52" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CreonMember_9ce3f9f9-2a28-411a-beb5-b6958bed4408" xlink:href="vtrs-20220630.xsd#vtrs_CreonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_CreonMember_9ce3f9f9-2a28-411a-beb5-b6958bed4408" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_XalabrandsMember_ee6de04e-c930-41be-93c3-eb5b4867f07e" xlink:href="vtrs-20220630.xsd#vtrs_XalabrandsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_XalabrandsMember_ee6de04e-c930-41be-93c3-eb5b4867f07e" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AmitizaMember_1b64b848-0527-4fed-b117-20b6882e4684" xlink:href="vtrs-20220630.xsd#vtrs_AmitizaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_AmitizaMember_1b64b848-0527-4fed-b117-20b6882e4684" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_XanaxMember_78d3dcee-aaf8-4908-9b24-d69bd845474f" xlink:href="vtrs-20220630.xsd#vtrs_XanaxMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_XanaxMember_78d3dcee-aaf8-4908-9b24-d69bd845474f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DymistaMember_3aebfa36-210b-4874-9183-2abe5887e6ff" xlink:href="vtrs-20220630.xsd#vtrs_DymistaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_DymistaMember_3aebfa36-210b-4874-9183-2abe5887e6ff" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_YupelriMember_61d3a753-23e3-4b53-8bf6-e7164ab6631c" xlink:href="vtrs-20220630.xsd#vtrs_YupelriMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_3008eaf2-da83-450c-8454-ded267895a39" xlink:to="loc_vtrs_YupelriMember_61d3a753-23e3-4b53-8bf6-e7164ab6631c" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="extended" id="i5b05f4ff6b1b4539958a2e1566817bcb_RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_cf2c35bc-8f09-464a-b59c-bff57b530905" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_5805b18d-fa4c-4eb5-8b13-28aae8667fd7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_cf2c35bc-8f09-464a-b59c-bff57b530905" xlink:to="loc_us-gaap_ReceivablesNetCurrent_5805b18d-fa4c-4eb5-8b13-28aae8667fd7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_d8428840-4aae-45e8-9e88-fdac768b74d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_cf2c35bc-8f09-464a-b59c-bff57b530905" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_d8428840-4aae-45e8-9e88-fdac768b74d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_cf253483-5e23-4b30-b4cb-9915fdaa4288" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_cf2c35bc-8f09-464a-b59c-bff57b530905" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_cf253483-5e23-4b30-b4cb-9915fdaa4288" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_71e194fb-32bc-441e-a8ea-2a072401b394" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_cf2c35bc-8f09-464a-b59c-bff57b530905" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_71e194fb-32bc-441e-a8ea-2a072401b394" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_e9385969-589e-4a29-a300-e5e0e4745c3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_71e194fb-32bc-441e-a8ea-2a072401b394" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_e9385969-589e-4a29-a300-e5e0e4745c3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_e9385969-589e-4a29-a300-e5e0e4745c3c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_e9385969-589e-4a29-a300-e5e0e4745c3c" xlink:to="loc_us-gaap_ReceivableTypeDomain_e9385969-589e-4a29-a300-e5e0e4745c3c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_6256d21e-ba19-43c8-a24c-e7ae9428a533" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_e9385969-589e-4a29-a300-e5e0e4745c3c" xlink:to="loc_us-gaap_ReceivableTypeDomain_6256d21e-ba19-43c8-a24c-e7ae9428a533" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_VariableConsiderationMember_35073b09-6142-4a1f-90bf-956b0cb3b046" xlink:href="vtrs-20220630.xsd#vtrs_VariableConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_6256d21e-ba19-43c8-a24c-e7ae9428a533" xlink:to="loc_vtrs_VariableConsiderationMember_35073b09-6142-4a1f-90bf-956b0cb3b046" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RecentAccountingPronouncementsRecentAccountingPronouncementsImpactofAdoptionASU201409Details" xlink:type="simple" xlink:href="vtrs-20220630.xsd#RecentAccountingPronouncementsRecentAccountingPronouncementsImpactofAdoptionASU201409Details"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/RecentAccountingPronouncementsRecentAccountingPronouncementsImpactofAdoptionASU201409Details" xlink:type="extended" id="i35c5e762c0ad4b9a86621426894a1177_RecentAccountingPronouncementsRecentAccountingPronouncementsImpactofAdoptionASU201409Details">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_9b03417f-dbb2-4b7d-962e-d21403d9a85f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_9b03417f-dbb2-4b7d-962e-d21403d9a85f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8bb1ddeb-5ea3-4b19-a5c6-e0467dee45ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8bb1ddeb-5ea3-4b19-a5c6-e0467dee45ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_362087d9-3f0d-4efb-b9bb-29b3db3b259e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_362087d9-3f0d-4efb-b9bb-29b3db3b259e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_10003137-2554-4431-9ebf-41b73f41feac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_Revenues_10003137-2554-4431-9ebf-41b73f41feac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f18e7298-248a-44a4-b3c5-89e8a8f45dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f18e7298-248a-44a4-b3c5-89e8a8f45dbd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_1f0a4529-05bd-40dd-98f0-2f183e8bed74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_1f0a4529-05bd-40dd-98f0-2f183e8bed74" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4bffea31-3d73-4fc2-8cf8-8830df2637cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_4bffea31-3d73-4fc2-8cf8-8830df2637cd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_93ec4c36-a7ed-4da9-8046-9a67cc1c9e50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_93ec4c36-a7ed-4da9-8046-9a67cc1c9e50" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_743e4c4c-9453-4f76-a9cc-0dda44294330" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_02b89ea3-872c-4e78-b792-99a5accdbdd4" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_743e4c4c-9453-4f76-a9cc-0dda44294330" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_cd66d5ff-db3c-49e5-b63c-815111540588" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_743e4c4c-9453-4f76-a9cc-0dda44294330" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_cd66d5ff-db3c-49e5-b63c-815111540588" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_cd66d5ff-db3c-49e5-b63c-815111540588_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_cd66d5ff-db3c-49e5-b63c-815111540588" xlink:to="loc_us-gaap_EquityComponentDomain_cd66d5ff-db3c-49e5-b63c-815111540588_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_660342f4-d5c1-44f9-b0bb-4e0ddbc1f5b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_cd66d5ff-db3c-49e5-b63c-815111540588" xlink:to="loc_us-gaap_EquityComponentDomain_660342f4-d5c1-44f9-b0bb-4e0ddbc1f5b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_451cc593-c72e-44fe-9c31-1a63f6af78c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_660342f4-d5c1-44f9-b0bb-4e0ddbc1f5b9" xlink:to="loc_us-gaap_RetainedEarningsMember_451cc593-c72e-44fe-9c31-1a63f6af78c8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ShareBasedIncentivePlanNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#ShareBasedIncentivePlanNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/ShareBasedIncentivePlanNarrativeDetails" xlink:type="extended" id="i6237b7b6a1784401850844c53074e2d8_ShareBasedIncentivePlanNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a0cd747e-e7a0-4572-a875-e438818e5700" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a0cd747e-e7a0-4572-a875-e438818e5700" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_10f4fe3d-adfc-4bcf-ace1-6842eceed2dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_10f4fe3d-adfc-4bcf-ace1-6842eceed2dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_e1357103-388c-4fff-8646-195cba839049" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_e1357103-388c-4fff-8646-195cba839049" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_19538b71-1171-4c4a-aef5-ae413db8bd14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_19538b71-1171-4c4a-aef5-ae413db8bd14" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_43ceda92-18cd-49fa-bbb2-562c7169e17d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_43ceda92-18cd-49fa-bbb2-562c7169e17d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_a065b848-1144-4253-b439-5402499d4bb7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_a065b848-1144-4253-b439-5402499d4bb7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_3c931483-e546-410a-908f-df1e335ad538" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_3c931483-e546-410a-908f-df1e335ad538" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_0836808f-6522-4c0b-864f-3b1353cb8199" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_0836808f-6522-4c0b-864f-3b1353cb8199" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_408fe69b-fcc0-49c3-8bfa-3b2351bad2dd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_408fe69b-fcc0-49c3-8bfa-3b2351bad2dd" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValueAndEquityInstrumentsOtherThanOptionsVestedInPeriodIntrinsicValue_eaed1985-3025-43d5-aa40-bfaee8d831cf" xlink:href="vtrs-20220630.xsd#vtrs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValueAndEquityInstrumentsOtherThanOptionsVestedInPeriodIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_vtrs_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValueAndEquityInstrumentsOtherThanOptionsVestedInPeriodIntrinsicValue_eaed1985-3025-43d5-aa40-bfaee8d831cf" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_8579b8d8-d3c4-49a0-b2a2-2dfbaba6235c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_8579b8d8-d3c4-49a0-b2a2-2dfbaba6235c" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_99cc5109-960b-4442-81c3-85550af97793" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_99cc5109-960b-4442-81c3-85550af97793" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_81bd389e-a658-4fe6-872a-92d30aeb5394" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProgramNameAxis_9b75e735-75db-4354-b5ff-f4a3b53b2291" xlink:href="vtrs-20220630.xsd#vtrs_ProgramNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:to="loc_vtrs_ProgramNameAxis_9b75e735-75db-4354-b5ff-f4a3b53b2291" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProgramNameDomain_9b75e735-75db-4354-b5ff-f4a3b53b2291_default" xlink:href="vtrs-20220630.xsd#vtrs_ProgramNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_vtrs_ProgramNameAxis_9b75e735-75db-4354-b5ff-f4a3b53b2291" xlink:to="loc_vtrs_ProgramNameDomain_9b75e735-75db-4354-b5ff-f4a3b53b2291_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProgramNameDomain_bc2c13a6-5706-40c2-9be2-885ebb7d26c6" xlink:href="vtrs-20220630.xsd#vtrs_ProgramNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_vtrs_ProgramNameAxis_9b75e735-75db-4354-b5ff-f4a3b53b2291" xlink:to="loc_vtrs_ProgramNameDomain_bc2c13a6-5706-40c2-9be2-885ebb7d26c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_1debf224-5f52-424b-884f-12e2c547fc7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:to="loc_us-gaap_PlanNameAxis_1debf224-5f52-424b-884f-12e2c547fc7a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_1debf224-5f52-424b-884f-12e2c547fc7a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_1debf224-5f52-424b-884f-12e2c547fc7a" xlink:to="loc_us-gaap_PlanNameDomain_1debf224-5f52-424b-884f-12e2c547fc7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_eda4c958-a076-4c98-b668-b9a58bd10b8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_1debf224-5f52-424b-884f-12e2c547fc7a" xlink:to="loc_us-gaap_PlanNameDomain_eda4c958-a076-4c98-b668-b9a58bd10b8f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_LongTermIncentivePlan2003Member_c6e0c390-41c4-46e5-96dc-f10db42c843d" xlink:href="vtrs-20220630.xsd#vtrs_LongTermIncentivePlan2003Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_eda4c958-a076-4c98-b668-b9a58bd10b8f" xlink:to="loc_vtrs_LongTermIncentivePlan2003Member_c6e0c390-41c4-46e5-96dc-f10db42c843d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2020StockIncentivePlanAnd2003LongTermIncentivePlanMember_39851f20-b69c-41f4-af5f-34401f5e607c" xlink:href="vtrs-20220630.xsd#vtrs_A2020StockIncentivePlanAnd2003LongTermIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_eda4c958-a076-4c98-b668-b9a58bd10b8f" xlink:to="loc_vtrs_A2020StockIncentivePlanAnd2003LongTermIncentivePlanMember_39851f20-b69c-41f4-af5f-34401f5e607c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_182f34cd-e20e-4128-a449-691708ed35c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:to="loc_us-gaap_AwardTypeAxis_182f34cd-e20e-4128-a449-691708ed35c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_182f34cd-e20e-4128-a449-691708ed35c1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_182f34cd-e20e-4128-a449-691708ed35c1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_182f34cd-e20e-4128-a449-691708ed35c1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d12ac338-538f-423b-b1e3-9726cd84bef3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_182f34cd-e20e-4128-a449-691708ed35c1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d12ac338-538f-423b-b1e3-9726cd84bef3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_4cf238ac-3417-4220-879b-eb242e29e783" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d12ac338-538f-423b-b1e3-9726cd84bef3" xlink:to="loc_us-gaap_EmployeeStockOptionMember_4cf238ac-3417-4220-879b-eb242e29e783" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:to="loc_srt_RangeAxis_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e" xlink:to="loc_srt_RangeMember_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_46e6ed7e-12f0-4302-94d8-50deddf76b07" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_d21ad809-3dd2-43c7-be1a-5c2a2429cc9e" xlink:to="loc_srt_RangeMember_46e6ed7e-12f0-4302-94d8-50deddf76b07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_b83e6968-233e-403d-85db-677a4e5f8a7e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_46e6ed7e-12f0-4302-94d8-50deddf76b07" xlink:to="loc_srt_MinimumMember_b83e6968-233e-403d-85db-677a4e5f8a7e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3a2f2dc1-1038-491d-8643-fe0f07269306" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_46e6ed7e-12f0-4302-94d8-50deddf76b07" xlink:to="loc_srt_MaximumMember_3a2f2dc1-1038-491d-8643-fe0f07269306" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_3f94e264-92b1-4806-8760-5c81952a3018" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8dd39b6c-e2e7-4333-8943-f38e93be3727" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_3f94e264-92b1-4806-8760-5c81952a3018" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3f94e264-92b1-4806-8760-5c81952a3018_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_3f94e264-92b1-4806-8760-5c81952a3018" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3f94e264-92b1-4806-8760-5c81952a3018_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d8028574-53a1-4df1-b755-3d049fa9918c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_3f94e264-92b1-4806-8760-5c81952a3018" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d8028574-53a1-4df1-b755-3d049fa9918c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ShareBasedIncentivePlanNonvestedRestrictedStockRestrictedStockUnitsandPSUsActivityDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#ShareBasedIncentivePlanNonvestedRestrictedStockRestrictedStockUnitsandPSUsActivityDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/ShareBasedIncentivePlanNonvestedRestrictedStockRestrictedStockUnitsandPSUsActivityDetails" xlink:type="extended" id="i71daee4426904be98292ba085f3e6d10_ShareBasedIncentivePlanNonvestedRestrictedStockRestrictedStockUnitsandPSUsActivityDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_869d8906-2b75-41fb-91f9-f827f4d0fef0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_869d8906-2b75-41fb-91f9-f827f4d0fef0" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f34e56e5-ef00-43dc-8981-675405685e9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f34e56e5-ef00-43dc-8981-675405685e9d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_a06f03ff-fd3d-46f4-bc11-03d835de1756" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_a06f03ff-fd3d-46f4-bc11-03d835de1756" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5307b74b-7937-468a-aeaf-e5f82fde7a07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5307b74b-7937-468a-aeaf-e5f82fde7a07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c18fa63a-b484-4359-84d1-e8f36ec3ff0e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c18fa63a-b484-4359-84d1-e8f36ec3ff0e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_136410ac-6405-4422-8825-319dd5286cd9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_136410ac-6405-4422-8825-319dd5286cd9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_0cd7ddeb-0103-456f-a49b-78fc9ff1e966" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_0cd7ddeb-0103-456f-a49b-78fc9ff1e966" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_f338c280-5b5c-45de-b382-6d08e9199046" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_f338c280-5b5c-45de-b382-6d08e9199046" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_ba075c3a-b4b5-4d6a-a19b-44b437c993c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_01182589-f530-4acd-980a-172b58f9115a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_ba075c3a-b4b5-4d6a-a19b-44b437c993c8" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_c0c852be-bcbc-4a4f-be53-0ec859804ff0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_a7defabb-b079-45f5-808e-3a9faf00bcce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_510524f4-0d93-4621-8fbe-2e4fd4a97911" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_869d8906-2b75-41fb-91f9-f827f4d0fef0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_510524f4-0d93-4621-8fbe-2e4fd4a97911" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_fc8a5897-f8dc-4220-b3d0-8498eacd1300" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_510524f4-0d93-4621-8fbe-2e4fd4a97911" xlink:to="loc_us-gaap_AwardTypeAxis_fc8a5897-f8dc-4220-b3d0-8498eacd1300" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fc8a5897-f8dc-4220-b3d0-8498eacd1300_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_fc8a5897-f8dc-4220-b3d0-8498eacd1300" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fc8a5897-f8dc-4220-b3d0-8498eacd1300_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_543a40a7-6b2f-42d9-b661-285ba881baa1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_fc8a5897-f8dc-4220-b3d0-8498eacd1300" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_543a40a7-6b2f-42d9-b661-285ba881baa1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_7b41aacb-9934-4573-b260-91fdf4c4ea20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_543a40a7-6b2f-42d9-b661-285ba881baa1" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_7b41aacb-9934-4573-b260-91fdf4c4ea20" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/PensionandOtherPostretirementBenefitNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#PensionandOtherPostretirementBenefitNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/PensionandOtherPostretirementBenefitNarrativeDetails" xlink:type="extended" id="i28ac2a0620614564b81446e4e094f01c_PensionandOtherPostretirementBenefitNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_0cc70c69-e879-4c42-8301-c70836287456" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Definedbenefitplansestimatedbenefitpaymentsincurrentfiscalyear_988ea514-212c-44ab-b612-6d22a6cebcf0" xlink:href="vtrs-20220630.xsd#vtrs_Definedbenefitplansestimatedbenefitpaymentsincurrentfiscalyear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_0cc70c69-e879-4c42-8301-c70836287456" xlink:to="loc_vtrs_Definedbenefitplansestimatedbenefitpaymentsincurrentfiscalyear_988ea514-212c-44ab-b612-6d22a6cebcf0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear_aaa9b4f2-dfac-419b-a784-b453a99e66a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_0cc70c69-e879-4c42-8301-c70836287456" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsRemainderOfFiscalYear_aaa9b4f2-dfac-419b-a784-b453a99e66a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4143370f-6ecc-41dc-95ff-6af8865d90aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_0cc70c69-e879-4c42-8301-c70836287456" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4143370f-6ecc-41dc-95ff-6af8865d90aa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_a5f29a23-bfcf-4b0e-b830-9f67d4020431" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4143370f-6ecc-41dc-95ff-6af8865d90aa" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_a5f29a23-bfcf-4b0e-b830-9f67d4020431" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_a5f29a23-bfcf-4b0e-b830-9f67d4020431_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_a5f29a23-bfcf-4b0e-b830-9f67d4020431" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_a5f29a23-bfcf-4b0e-b830-9f67d4020431_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8e015d82-ff43-470b-9b7f-ca834eb7a43e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_a5f29a23-bfcf-4b0e-b830-9f67d4020431" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8e015d82-ff43-470b-9b7f-ca834eb7a43e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="extended" id="iecfb85e682ac445994e7619f977e9b2a_PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_78bd558a-c204-4e19-ac87-9d04901982d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_78bd558a-c204-4e19-ac87-9d04901982d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_56ceec18-ff38-4424-93de-5e44b381644b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_56ceec18-ff38-4424-93de-5e44b381644b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_4c97e774-ad58-4f2a-82da-524cad2d44a7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_4c97e774-ad58-4f2a-82da-524cad2d44a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_57477b6a-5c80-468e-a6ab-a54ff735e311" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_57477b6a-5c80-468e-a6ab-a54ff735e311" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_5b12705a-affd-4040-8fde-7e38b4e570fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_5b12705a-affd-4040-8fde-7e38b4e570fa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_2abdbf1c-c7c7-4160-8668-019819419da9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_2abdbf1c-c7c7-4160-8668-019819419da9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_9bcdaab3-54c9-41c2-a859-6c81ff2832cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_9bcdaab3-54c9-41c2-a859-6c81ff2832cb" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_07afcfe0-4015-4ecc-b694-e47ff08f94d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca8a7b14-33c9-45f6-90f5-0d75b7b72463" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_07afcfe0-4015-4ecc-b694-e47ff08f94d6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_b04037bb-61de-4bb7-a7b9-4e8884f40ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_07afcfe0-4015-4ecc-b694-e47ff08f94d6" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_b04037bb-61de-4bb7-a7b9-4e8884f40ba6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_b04037bb-61de-4bb7-a7b9-4e8884f40ba6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_b04037bb-61de-4bb7-a7b9-4e8884f40ba6" xlink:to="loc_us-gaap_EquityComponentDomain_b04037bb-61de-4bb7-a7b9-4e8884f40ba6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_7716e082-f71b-4937-8859-63fda7b6664f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_b04037bb-61de-4bb7-a7b9-4e8884f40ba6" xlink:to="loc_us-gaap_EquityComponentDomain_7716e082-f71b-4937-8859-63fda7b6664f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_ca0278bc-7089-4997-9720-1439b4d30f2a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7716e082-f71b-4937-8859-63fda7b6664f" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_ca0278bc-7089-4997-9720-1439b4d30f2a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_07afcfe0-4015-4ecc-b694-e47ff08f94d6" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_2e385ff3-5d4d-4214-8b37-0548682e671c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_6bf0fad9-003f-42a1-a73d-cc43d5fe87f9" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_2e385ff3-5d4d-4214-8b37-0548682e671c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_67282885-880d-47c5-9ff5-732b4a96ca50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_2e385ff3-5d4d-4214-8b37-0548682e671c" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_67282885-880d-47c5-9ff5-732b4a96ca50" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_2620f4a7-ddda-4174-9d2e-08ac6b6aede3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_07afcfe0-4015-4ecc-b694-e47ff08f94d6" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_2620f4a7-ddda-4174-9d2e-08ac6b6aede3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_2620f4a7-ddda-4174-9d2e-08ac6b6aede3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_2620f4a7-ddda-4174-9d2e-08ac6b6aede3" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_2620f4a7-ddda-4174-9d2e-08ac6b6aede3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_ab012c8d-29d3-4404-8b93-84ded1dd5edb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_2620f4a7-ddda-4174-9d2e-08ac6b6aede3" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_ab012c8d-29d3-4404-8b93-84ded1dd5edb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember_51f3bb21-37ff-4b9a-ab72-6042a276eb16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_ab012c8d-29d3-4404-8b93-84ded1dd5edb" xlink:to="loc_us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember_51f3bb21-37ff-4b9a-ab72-6042a276eb16" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended" id="if4a13942cbc747f68f2df0b04dae2a9a_BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_c19a041a-a074-4b15-b21a-12ecb2b91fc9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_c19a041a-a074-4b15-b21a-12ecb2b91fc9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ca1a21d7-cb1c-483b-a8f0-b1533b2c91b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ca1a21d7-cb1c-483b-a8f0-b1533b2c91b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_74fc892f-56a2-49c7-b948-53cd2a23d41c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_74fc892f-56a2-49c7-b948-53cd2a23d41c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_83c1df2c-954a-4146-9be6-8c3333118b4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_TradingSecurities_83c1df2c-954a-4146-9be6-8c3333118b4b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_02fe77e2-1627-4c78-874b-2cffa93fd37f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_OtherAssetsCurrent_02fe77e2-1627-4c78-874b-2cffa93fd37f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_aa55515a-a5a3-4871-843e-a5c39dd0c035" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_aa55515a-a5a3-4871-843e-a5c39dd0c035" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cf9c2740-8870-487d-9664-4dcf62c89153" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_a150eadf-2f30-41fb-b7d6-557386ff1c2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_a150eadf-2f30-41fb-b7d6-557386ff1c2f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_a150eadf-2f30-41fb-b7d6-557386ff1c2f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_a150eadf-2f30-41fb-b7d6-557386ff1c2f" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_a150eadf-2f30-41fb-b7d6-557386ff1c2f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_bbf23192-be7b-4eea-8e23-42f03b9014e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_a150eadf-2f30-41fb-b7d6-557386ff1c2f" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_bbf23192-be7b-4eea-8e23-42f03b9014e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesMember_43a6b5b2-db15-4407-9634-feab137e5a17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_bbf23192-be7b-4eea-8e23-42f03b9014e8" xlink:to="loc_us-gaap_DebtSecuritiesMember_43a6b5b2-db15-4407-9634-feab137e5a17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_63d96ab5-8a77-4d2e-b567-05875fb654e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_63d96ab5-8a77-4d2e-b567-05875fb654e2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_63d96ab5-8a77-4d2e-b567-05875fb654e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_63d96ab5-8a77-4d2e-b567-05875fb654e2" xlink:to="loc_us-gaap_ReceivableTypeDomain_63d96ab5-8a77-4d2e-b567-05875fb654e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_ab48b282-ca18-41f5-8761-514e2d6371c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_63d96ab5-8a77-4d2e-b567-05875fb654e2" xlink:to="loc_us-gaap_ReceivableTypeDomain_ab48b282-ca18-41f5-8761-514e2d6371c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_VariableConsiderationMember_f2924c78-14c0-4d75-9b8a-cb403240ad2a" xlink:href="vtrs-20220630.xsd#vtrs_VariableConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_ab48b282-ca18-41f5-8761-514e2d6371c9" xlink:to="loc_vtrs_VariableConsiderationMember_f2924c78-14c0-4d75-9b8a-cb403240ad2a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_062b3a10-184b-4085-93e8-d66c74899ad5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_062b3a10-184b-4085-93e8-d66c74899ad5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_062b3a10-184b-4085-93e8-d66c74899ad5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_062b3a10-184b-4085-93e8-d66c74899ad5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_062b3a10-184b-4085-93e8-d66c74899ad5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_904e8e97-2dff-4c26-9500-7b40d9fc12f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_062b3a10-184b-4085-93e8-d66c74899ad5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_904e8e97-2dff-4c26-9500-7b40d9fc12f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_32e20e19-a9fa-4938-8a3c-8c136f8d986b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_904e8e97-2dff-4c26-9500-7b40d9fc12f8" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_32e20e19-a9fa-4938-8a3c-8c136f8d986b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_88a30bd5-e283-4778-a1bc-f589fa3e6282" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_0149b6ef-b9d0-4d74-9d66-202d334fc234" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_88a30bd5-e283-4778-a1bc-f589fa3e6282" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_88a30bd5-e283-4778-a1bc-f589fa3e6282_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_88a30bd5-e283-4778-a1bc-f589fa3e6282" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_88a30bd5-e283-4778-a1bc-f589fa3e6282_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_a3c4173d-2665-46e7-8db9-6acc0082d307" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_88a30bd5-e283-4778-a1bc-f589fa3e6282" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_a3c4173d-2665-46e7-8db9-6acc0082d307" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CleanEnergyPartnershipsMember_7e81fd55-b8ce-4dc3-93aa-8d0bea4d7a4d" xlink:href="vtrs-20220630.xsd#vtrs_CleanEnergyPartnershipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_a3c4173d-2665-46e7-8db9-6acc0082d307" xlink:to="loc_vtrs_CleanEnergyPartnershipsMember_7e81fd55-b8ce-4dc3-93aa-8d0bea4d7a4d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#BalanceSheetComponentsPropertyPlantandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="extended" id="i3bb1b842b8c34929ab3842f69983b64e_BalanceSheetComponentsPropertyPlantandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e0e538d2-542c-4617-b17b-14f75fe3cdc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_dcd9095c-dd5b-47f2-8e29-eb990d85cd04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e0e538d2-542c-4617-b17b-14f75fe3cdc8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_dcd9095c-dd5b-47f2-8e29-eb990d85cd04" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_446fb2ab-f99e-413d-9743-685206860525" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e0e538d2-542c-4617-b17b-14f75fe3cdc8" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_446fb2ab-f99e-413d-9743-685206860525" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_90529e99-74e8-44dc-b9f6-0baf333f1ab4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e0e538d2-542c-4617-b17b-14f75fe3cdc8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_90529e99-74e8-44dc-b9f6-0baf333f1ab4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_966ce0dd-7e58-4e73-bd0a-bfe6794e138e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_e0e538d2-542c-4617-b17b-14f75fe3cdc8" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_966ce0dd-7e58-4e73-bd0a-bfe6794e138e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_74ffd260-5c65-4fe7-9554-57fe4f57e46c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_966ce0dd-7e58-4e73-bd0a-bfe6794e138e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_74ffd260-5c65-4fe7-9554-57fe4f57e46c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_74ffd260-5c65-4fe7-9554-57fe4f57e46c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_74ffd260-5c65-4fe7-9554-57fe4f57e46c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_74ffd260-5c65-4fe7-9554-57fe4f57e46c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_74ffd260-5c65-4fe7-9554-57fe4f57e46c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_cb2f9a4e-eb4f-4fd2-8e67-75ab298a1091" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_cb2f9a4e-eb4f-4fd2-8e67-75ab298a1091" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_fd75099b-07fc-4ef5-998c-82465aa74161" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_fd75099b-07fc-4ef5-998c-82465aa74161" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_57319eda-3e85-47a6-a451-37732ff7b019" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:to="loc_us-gaap_ConstructionInProgressMember_57319eda-3e85-47a6-a451-37732ff7b019" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndLandImprovementsMember_2a019a18-294b-47be-b695-99feb01a6786" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LandAndLandImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_507a8066-1600-4655-b402-08d24a27e1d1" xlink:to="loc_us-gaap_LandAndLandImprovementsMember_2a019a18-294b-47be-b695-99feb01a6786" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#BalanceSheetComponentsOtherCurrentLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherCurrentLiabilitiesDetails" xlink:type="extended" id="iad3d9b61bf4a4db6aa83d0c33a819b6c_BalanceSheetComponentsOtherCurrentLiabilitiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleofothercurrentliabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_302c6e07-3166-4b93-82ab-418f382a7383" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_302c6e07-3166-4b93-82ab-418f382a7383" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_747a5a69-9ed5-40f6-af93-cc5551f2f2db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_LitigationReserveCurrent_747a5a69-9ed5-40f6-af93-cc5551f2f2db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e8599844-5a65-457c-ba0a-4c24040162e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e8599844-5a65-457c-ba0a-4c24040162e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_f821d88b-0adc-4f02-b51a-197061eda1cb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_f821d88b-0adc-4f02-b51a-197061eda1cb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_3dd6dc8f-f1b3-4a8a-a24a-e12af2d10834" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_RestructuringReserveCurrent_3dd6dc8f-f1b3-4a8a-a24a-e12af2d10834" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_2dba041a-2d98-49fb-af9a-9ec6032bc4b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_InterestPayableCurrent_2dba041a-2d98-49fb-af9a-9ec6032bc4b0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_8f046034-2539-4d29-b938-75d518328cb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_8f046034-2539-4d29-b938-75d518328cb4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_975f42c4-da68-4788-a107-abc63fcff57e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_975f42c4-da68-4788-a107-abc63fcff57e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_6957feb7-8e38-471a-82ab-6aec679fa823" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_6957feb7-8e38-471a-82ab-6aec679fa823" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_1f679450-327a-4278-8d17-3f921b37296d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_1f679450-327a-4278-8d17-3f921b37296d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleofothercurrentliabilitiesTable_9128d63e-b09e-4b6c-afd1-66f7736b9720" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleofothercurrentliabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesLineItems_8550d914-b822-4561-b1b7-9d2b7bfe61b0" xlink:to="loc_vtrs_ScheduleofothercurrentliabilitiesTable_9128d63e-b09e-4b6c-afd1-66f7736b9720" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_2fc5e473-832d-4ca9-aae9-b7091e29bba4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesTable_9128d63e-b09e-4b6c-afd1-66f7736b9720" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_2fc5e473-832d-4ca9-aae9-b7091e29bba4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_2fc5e473-832d-4ca9-aae9-b7091e29bba4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_2fc5e473-832d-4ca9-aae9-b7091e29bba4" xlink:to="loc_us-gaap_ReceivableTypeDomain_2fc5e473-832d-4ca9-aae9-b7091e29bba4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_5560ffe4-59f7-483b-bb7a-6d23ce307ad7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_2fc5e473-832d-4ca9-aae9-b7091e29bba4" xlink:to="loc_us-gaap_ReceivableTypeDomain_5560ffe4-59f7-483b-bb7a-6d23ce307ad7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_VariableConsiderationMember_cde6dfa1-6184-432e-a986-6e162d9ac886" xlink:href="vtrs-20220630.xsd#vtrs_VariableConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_5560ffe4-59f7-483b-bb7a-6d23ce307ad7" xlink:to="loc_vtrs_VariableConsiderationMember_cde6dfa1-6184-432e-a986-6e162d9ac886" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_4f009cd3-ada2-4abf-b645-2371dff6dff0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesTable_9128d63e-b09e-4b6c-afd1-66f7736b9720" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_4f009cd3-ada2-4abf-b645-2371dff6dff0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_4f009cd3-ada2-4abf-b645-2371dff6dff0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_4f009cd3-ada2-4abf-b645-2371dff6dff0" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_4f009cd3-ada2-4abf-b645-2371dff6dff0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_0569f25c-6e72-4bca-b696-a434c30ae29b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_4f009cd3-ada2-4abf-b645-2371dff6dff0" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_0569f25c-6e72-4bca-b696-a434c30ae29b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_e2005c0d-0a49-4e3b-b069-49bb683651b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_0569f25c-6e72-4bca-b696-a434c30ae29b" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_e2005c0d-0a49-4e3b-b069-49bb683651b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_765c1f7e-8c29-40d2-bb82-73941492bb8c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_vtrs_ScheduleofothercurrentliabilitiesTable_9128d63e-b09e-4b6c-afd1-66f7736b9720" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_765c1f7e-8c29-40d2-bb82-73941492bb8c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_765c1f7e-8c29-40d2-bb82-73941492bb8c_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_765c1f7e-8c29-40d2-bb82-73941492bb8c" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_765c1f7e-8c29-40d2-bb82-73941492bb8c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_1ce8dc0b-f251-4dee-b559-b6242777447e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_765c1f7e-8c29-40d2-bb82-73941492bb8c" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_1ce8dc0b-f251-4dee-b559-b6242777447e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CleanEnergyPartnershipsMember_a2f21e43-bbfc-4d4b-ace9-7232c52dd9e1" xlink:href="vtrs-20220630.xsd#vtrs_CleanEnergyPartnershipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_1ce8dc0b-f251-4dee-b559-b6242777447e" xlink:to="loc_vtrs_CleanEnergyPartnershipsMember_a2f21e43-bbfc-4d4b-ace9-7232c52dd9e1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherLongtermObligationsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#BalanceSheetComponentsOtherLongtermObligationsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherLongtermObligationsDetails" xlink:type="extended" id="iffbe5f418b0d43c09b9e37cff8fe8153_BalanceSheetComponentsOtherLongtermObligationsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_132d5251-b1f2-4b6a-8742-f768102a5cd1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_132d5251-b1f2-4b6a-8742-f768102a5cd1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_48ffa64f-5b97-4f05-9927-3bd112783a9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_48ffa64f-5b97-4f05-9927-3bd112783a9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_7adfff8d-0ac0-48e2-ab36-7990a1e996e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilityForUncertainTaxPositionsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_7adfff8d-0ac0-48e2-ab36-7990a1e996e6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ae9403ea-5c48-4029-9603-9ef8aa35809d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ae9403ea-5c48-4029-9603-9ef8aa35809d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveNoncurrent_634f9b2e-d7c1-46b5-9a24-e707a5f739d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserveNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_RestructuringReserveNoncurrent_634f9b2e-d7c1-46b5-9a24-e707a5f739d4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_194452fb-ac1c-4066-9e4a-a992d8960387" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_LiabilitiesOtherThanLongtermDebtNoncurrent_194452fb-ac1c-4066-9e4a-a992d8960387" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_50eadfc9-cb97-4801-b374-8eb91b4de344" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_50eadfc9-cb97-4801-b374-8eb91b4de344" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesTable_a772e0f8-53ed-4d9b-826c-aa39aa72b8b2" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleofOtherNoncurrentLiabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesLineItems_de6cba98-ea85-4612-8739-95553a354b7c" xlink:to="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesTable_a772e0f8-53ed-4d9b-826c-aa39aa72b8b2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_e17edefb-a16b-4bc0-b121-ac40a560118d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_vtrs_ScheduleofOtherNoncurrentLiabilitiesTable_a772e0f8-53ed-4d9b-826c-aa39aa72b8b2" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_e17edefb-a16b-4bc0-b121-ac40a560118d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_e17edefb-a16b-4bc0-b121-ac40a560118d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_e17edefb-a16b-4bc0-b121-ac40a560118d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_e17edefb-a16b-4bc0-b121-ac40a560118d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ee013886-0ebd-4c29-8da2-bc8f1227880f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_e17edefb-a16b-4bc0-b121-ac40a560118d" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ee013886-0ebd-4c29-8da2-bc8f1227880f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8db76b10-c964-4294-9c91-19d686c4e3a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ee013886-0ebd-4c29-8da2-bc8f1227880f" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_8db76b10-c964-4294-9c91-19d686c4e3a0" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsAssetsandLiabilitiesHeldForSaleDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#BalanceSheetComponentsAssetsandLiabilitiesHeldForSaleDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsAssetsandLiabilitiesHeldForSaleDetails" xlink:type="extended" id="ic1e8f9201f3d4f148a2688680db8c437_BalanceSheetComponentsAssetsandLiabilitiesHeldForSaleDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCash_9e4b59cb-92cf-4ffd-8649-294d8c471502" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationCash_9e4b59cb-92cf-4ffd-8649-294d8c471502" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationConvertiblePreferredEquityPercentOwnership_66f1af39-591b-408e-a7b2-2e6e461d2fea" xlink:href="vtrs-20220630.xsd#vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationConvertiblePreferredEquityPercentOwnership"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationConvertiblePreferredEquityPercentOwnership_66f1af39-591b-408e-a7b2-2e6e461d2fea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationArrangementsRangeOfOutcomesHigh_66fa7e46-2bc1-41e7-9d14-281bfe0ca180" xlink:href="vtrs-20220630.xsd#vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationArrangementsRangeOfOutcomesHigh"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationConsiderationContingentConsiderationArrangementsRangeOfOutcomesHigh_66fa7e46-2bc1-41e7-9d14-281bfe0ca180" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationsTermOfTransitionServicesAgreement_de1ea904-8477-48eb-ba70-51b00f8ff189" xlink:href="vtrs-20220630.xsd#vtrs_DisposalGroupIncludingDiscontinuedOperationsTermOfTransitionServicesAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationsTermOfTransitionServicesAgreement_de1ea904-8477-48eb-ba70-51b00f8ff189" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_ab496bc7-c43a-4a18-b7ad-6808062dfe69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationRevenue_ab496bc7-c43a-4a18-b7ad-6808062dfe69" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet_0bf7d2e6-1cc5-4a33-be31-84c0029b0c54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsNotesAndLoansReceivableNet_0bf7d2e6-1cc5-4a33-be31-84c0029b0c54" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_fafa0b1d-63ca-49b4-a564-a3f75956d85e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_fafa0b1d-63ca-49b4-a564-a3f75956d85e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_051144b6-abe2-4f18-96a1-3e37a0cff8b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_051144b6-abe2-4f18-96a1-3e37a0cff8b4" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets_f071e66e-8294-4a77-a298-2913bceac766" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssets_f071e66e-8294-4a77-a298-2913bceac766" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwill1_8f21b34c-5c9b-483b-9147-c9623b7f73df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwill1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwill1_8f21b34c-5c9b-483b-9147-c9623b7f73df" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherAssets_e45f9dca-7c23-4207-b87d-f78c962ad4b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherAssets_e45f9dca-7c23-4207-b87d-f78c962ad4b6" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayable_78e0400d-392c-414d-b93d-a4f18a1bbf5d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAccountsPayable_78e0400d-392c-414d-b93d-a4f18a1bbf5d" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities_120e4fdf-90cb-4b47-a63a-e70a5caeed13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationOtherCurrentLiabilities_120e4fdf-90cb-4b47-a63a-e70a5caeed13" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_e5ad1861-5513-4e62-bad8-da216380d743" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_e5ad1861-5513-4e62-bad8-da216380d743" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_86f3ea86-01ef-49be-ab28-54ed23c4ab6a" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_d0faa390-2bd0-4260-b873-502a76f41569" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_d0faa390-2bd0-4260-b873-502a76f41569" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_d0faa390-2bd0-4260-b873-502a76f41569_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_d0faa390-2bd0-4260-b873-502a76f41569" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_d0faa390-2bd0-4260-b873-502a76f41569_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_5c06470f-4062-4d97-9af4-d3d2536f7f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_d0faa390-2bd0-4260-b873-502a76f41569" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_5c06470f-4062-4d97-9af4-d3d2536f7f3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupHeldForSaleOrDisposedOfBySaleNotDiscontinuedOperationsMember_0a269361-a640-46a4-942d-873d76b3b1ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupHeldForSaleOrDisposedOfBySaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_5c06470f-4062-4d97-9af4-d3d2536f7f3f" xlink:to="loc_us-gaap_DisposalGroupHeldForSaleOrDisposedOfBySaleNotDiscontinuedOperationsMember_0a269361-a640-46a4-942d-873d76b3b1ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_srt_StatementScenarioAxis_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01" xlink:to="loc_srt_ScenarioUnspecifiedDomain_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_76b2a158-ce64-425b-9fa2-f77b3d9373c0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_fdc1e85c-a308-4bef-8dc2-7100cc3b1e01" xlink:to="loc_srt_ScenarioUnspecifiedDomain_76b2a158-ce64-425b-9fa2-f77b3d9373c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_6995412c-f54d-4657-bf36-20252f873e17" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_76b2a158-ce64-425b-9fa2-f77b3d9373c0" xlink:to="loc_srt_ScenarioForecastMember_6995412c-f54d-4657-bf36-20252f873e17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_3026ad4c-c0f0-42e1-b97b-b40448016508" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_srt_CounterpartyNameAxis_3026ad4c-c0f0-42e1-b97b-b40448016508" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3026ad4c-c0f0-42e1-b97b-b40448016508_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_3026ad4c-c0f0-42e1-b97b-b40448016508" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3026ad4c-c0f0-42e1-b97b-b40448016508_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f769b42-9f6a-4809-8940-0467c45e9033" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_3026ad4c-c0f0-42e1-b97b-b40448016508" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f769b42-9f6a-4809-8940-0467c45e9033" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BioconBiologicsMember_7149b539-bebc-49e8-90a3-645aa18182da" xlink:href="vtrs-20220630.xsd#vtrs_BioconBiologicsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2f769b42-9f6a-4809-8940-0467c45e9033" xlink:to="loc_vtrs_BioconBiologicsMember_7149b539-bebc-49e8-90a3-645aa18182da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_78af3b90-0f1f-4d3a-9fb4-3983d54692b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_78af3b90-0f1f-4d3a-9fb4-3983d54692b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_78af3b90-0f1f-4d3a-9fb4-3983d54692b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_78af3b90-0f1f-4d3a-9fb4-3983d54692b4" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_78af3b90-0f1f-4d3a-9fb4-3983d54692b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_fb4e38be-fb95-41d3-a8f4-eff247b7c174" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_78af3b90-0f1f-4d3a-9fb4-3983d54692b4" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_fb4e38be-fb95-41d3-a8f4-eff247b7c174" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BiosimilarsPortfolioMember_fa40bc51-48a9-4ae9-a7b8-efa7c1cba8af" xlink:href="vtrs-20220630.xsd#vtrs_BiosimilarsPortfolioMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_fb4e38be-fb95-41d3-a8f4-eff247b7c174" xlink:to="loc_vtrs_BiosimilarsPortfolioMember_fa40bc51-48a9-4ae9-a7b8-efa7c1cba8af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1949001a-d87a-4258-b767-0eb723c036c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1949001a-d87a-4258-b767-0eb723c036c0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_1949001a-d87a-4258-b767-0eb723c036c0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1949001a-d87a-4258-b767-0eb723c036c0" xlink:to="loc_us-gaap_ReceivableTypeDomain_1949001a-d87a-4258-b767-0eb723c036c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_474ebfca-3229-4109-b6cf-d52215314b92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_1949001a-d87a-4258-b767-0eb723c036c0" xlink:to="loc_us-gaap_ReceivableTypeDomain_474ebfca-3229-4109-b6cf-d52215314b92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_VariableConsiderationMember_57e2c595-df67-4280-852b-1bf251a42630" xlink:href="vtrs-20220630.xsd#vtrs_VariableConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReceivableTypeDomain_474ebfca-3229-4109-b6cf-d52215314b92" xlink:to="loc_vtrs_VariableConsiderationMember_57e2c595-df67-4280-852b-1bf251a42630" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_03ff860a-dd3e-457a-8b2a-b15f12c6df62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_03ff860a-dd3e-457a-8b2a-b15f12c6df62" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_03ff860a-dd3e-457a-8b2a-b15f12c6df62_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_03ff860a-dd3e-457a-8b2a-b15f12c6df62" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_03ff860a-dd3e-457a-8b2a-b15f12c6df62_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_d530eaf1-0c59-4b30-996b-64ba5499326f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_03ff860a-dd3e-457a-8b2a-b15f12c6df62" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_d530eaf1-0c59-4b30-996b-64ba5499326f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_baa0b791-5bbb-43fc-9805-e113db299135" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_d530eaf1-0c59-4b30-996b-64ba5499326f" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_baa0b791-5bbb-43fc-9805-e113db299135" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ce552b12-c7f7-454b-a27d-c327dc566795" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_1e2d558f-ae10-4d8d-b255-50ae1799734d" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ce552b12-c7f7-454b-a27d-c327dc566795" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_ce552b12-c7f7-454b-a27d-c327dc566795_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ce552b12-c7f7-454b-a27d-c327dc566795" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_ce552b12-c7f7-454b-a27d-c327dc566795_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_bef01b88-03fd-4977-9ea4-8d97c7e7b68f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_ce552b12-c7f7-454b-a27d-c327dc566795" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_bef01b88-03fd-4977-9ea4-8d97c7e7b68f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CleanEnergyPartnershipsMember_e6dfdd16-80bb-498e-affb-411f4c3289b6" xlink:href="vtrs-20220630.xsd#vtrs_CleanEnergyPartnershipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_bef01b88-03fd-4977-9ea4-8d97c7e7b68f" xlink:to="loc_vtrs_CleanEnergyPartnershipsMember_e6dfdd16-80bb-498e-affb-411f4c3289b6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EquityMethodInvestmentsNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#EquityMethodInvestmentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/EquityMethodInvestmentsNarrativeDetails" xlink:type="extended" id="ie864011d2d564991a5aa46d28e28d470_EquityMethodInvestmentsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_c85657ee-feb5-43b7-8beb-47412e8d0000" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Numberofequitymethodinvestments_2993ce9d-67e5-448d-b88c-3e57aa9642f4" xlink:href="vtrs-20220630.xsd#vtrs_Numberofequitymethodinvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_c85657ee-feb5-43b7-8beb-47412e8d0000" xlink:to="loc_vtrs_Numberofequitymethodinvestments_2993ce9d-67e5-448d-b88c-3e57aa9642f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EquityMethodInvestmentsSummarizedFinancialDataBasis_9f7d29e1-ae8e-411e-a04b-c5b6010761af" xlink:href="vtrs-20220630.xsd#vtrs_EquityMethodInvestmentsSummarizedFinancialDataBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_c85657ee-feb5-43b7-8beb-47412e8d0000" xlink:to="loc_vtrs_EquityMethodInvestmentsSummarizedFinancialDataBasis_9f7d29e1-ae8e-411e-a04b-c5b6010761af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_779b8b8b-6783-405f-b731-e40bb139306e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_c85657ee-feb5-43b7-8beb-47412e8d0000" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_779b8b8b-6783-405f-b731-e40bb139306e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1e357be3-699b-4b6c-b443-bad31f57234d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_c85657ee-feb5-43b7-8beb-47412e8d0000" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1e357be3-699b-4b6c-b443-bad31f57234d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_02b89be0-0505-467d-822e-17bd29e505e2" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_1e357be3-699b-4b6c-b443-bad31f57234d" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_02b89be0-0505-467d-822e-17bd29e505e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_02b89be0-0505-467d-822e-17bd29e505e2_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_02b89be0-0505-467d-822e-17bd29e505e2" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_02b89be0-0505-467d-822e-17bd29e505e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0235cab5-c9f1-47d5-8945-75d8f686f21f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_02b89be0-0505-467d-822e-17bd29e505e2" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0235cab5-c9f1-47d5-8945-75d8f686f21f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CleanEnergyPartnershipsMember_e4e2f37c-edc2-4c3d-9796-0932c7fb489d" xlink:href="vtrs-20220630.xsd#vtrs_CleanEnergyPartnershipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_0235cab5-c9f1-47d5-8945-75d8f686f21f" xlink:to="loc_vtrs_CleanEnergyPartnershipsMember_e4e2f37c-edc2-4c3d-9796-0932c7fb489d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EquityMethodInvestmentsIncomeStatementDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#EquityMethodInvestmentsIncomeStatementDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/EquityMethodInvestmentsIncomeStatementDetails" xlink:type="extended" id="ieee47ea14183428aae919a4de9dac790_EquityMethodInvestmentsIncomeStatementDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_719eadfd-7ded-481a-acef-1a14620711c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:to="loc_us-gaap_Revenues_719eadfd-7ded-481a-acef-1a14620711c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_6d7c547c-4e4a-4a78-a943-11a3c785ccee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:to="loc_us-gaap_GrossProfit_6d7c547c-4e4a-4a78-a943-11a3c785ccee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b59c1e9c-69d2-42fe-b1d2-e6224869bb1a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_b59c1e9c-69d2-42fe-b1d2-e6224869bb1a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_75c10b00-d630-478f-bda8-7ac485420c15" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:to="loc_us-gaap_ProfitLoss_75c10b00-d630-478f-bda8-7ac485420c15" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0e0ddfb6-9a22-49ee-bda2-b055ec4db8b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_e18773e8-8323-4aa8-8b87-603e2672f005" xlink:to="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0e0ddfb6-9a22-49ee-bda2-b055ec4db8b0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_c0177484-4f82-49f6-8dc7-4cc6680cb570" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEquityMethodInvestmentsTable_0e0ddfb6-9a22-49ee-bda2-b055ec4db8b0" xlink:to="loc_srt_ConsolidatedEntitiesAxis_c0177484-4f82-49f6-8dc7-4cc6680cb570" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_c0177484-4f82-49f6-8dc7-4cc6680cb570_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_c0177484-4f82-49f6-8dc7-4cc6680cb570" xlink:to="loc_srt_ConsolidatedEntitiesDomain_c0177484-4f82-49f6-8dc7-4cc6680cb570_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_292795bb-5268-4a88-86b6-f3de24a289de" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_c0177484-4f82-49f6-8dc7-4cc6680cb570" xlink:to="loc_srt_ConsolidatedEntitiesDomain_292795bb-5268-4a88-86b6-f3de24a289de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidatedEntityExcludingVieMember_153c682c-b9e7-43c6-bdda-2fcf837d404d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConsolidatedEntityExcludingVieMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_292795bb-5268-4a88-86b6-f3de24a289de" xlink:to="loc_us-gaap_ConsolidatedEntityExcludingVieMember_153c682c-b9e7-43c6-bdda-2fcf837d404d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EarningsLossperOrdinaryShareNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#EarningsLossperOrdinaryShareNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/EarningsLossperOrdinaryShareNarrativeDetails" xlink:type="extended" id="ia5093d1f310640f1a786c7cde14f3a30_EarningsLossperOrdinaryShareNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareBasicLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_182820b3-d221-4e02-a689-953fed04fa59" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_EarningsPerShareDiluted_182820b3-d221-4e02-a689-953fed04fa59" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_2fa6bbb5-1a93-4340-b94a-2c71d1acfb74" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_2fa6bbb5-1a93-4340-b94a-2c71d1acfb74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareCashPaid_662276f9-f4ac-4545-823a-071b6456dbe6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_CommonStockDividendsPerShareCashPaid_662276f9-f4ac-4545-823a-071b6456dbe6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_1ad04183-f46a-4d7c-8688-04c54f241c7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_1ad04183-f46a-4d7c-8688-04c54f241c7c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsPayableAmountPerShare_3b974ff8-46f8-43b4-a2f9-671258f4b797" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DividendsPayableAmountPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_DividendsPayableAmountPerShare_3b974ff8-46f8-43b4-a2f9-671258f4b797" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_005e9c2e-8341-4bd3-9f7a-41b80ac2d65e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_005e9c2e-8341-4bd3-9f7a-41b80ac2d65e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_3408283a-6300-46e4-9240-b5baf4cef4bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EarningsPerShareBasicLineItems_fc438feb-e3f9-443d-97ff-30a1727569d2" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_3408283a-6300-46e4-9240-b5baf4cef4bb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_aa36a497-ed42-4cca-b34a-bd6ce7785fae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_3408283a-6300-46e4-9240-b5baf4cef4bb" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_aa36a497-ed42-4cca-b34a-bd6ce7785fae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_aa36a497-ed42-4cca-b34a-bd6ce7785fae_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_aa36a497-ed42-4cca-b34a-bd6ce7785fae" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_aa36a497-ed42-4cca-b34a-bd6ce7785fae_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_aa2c69a8-30fc-4343-9182-d25f84538f12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_aa36a497-ed42-4cca-b34a-bd6ce7785fae" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_aa2c69a8-30fc-4343-9182-d25f84538f12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_ecf0e22f-2696-439d-b1cf-61a2fe813ace" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_aa2c69a8-30fc-4343-9182-d25f84538f12" xlink:to="loc_us-gaap_SubsequentEventMember_ecf0e22f-2696-439d-b1cf-61a2fe813ace" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#GoodwillandIntangibleAssetsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsNarrativeDetails" xlink:type="extended" id="ia22d92d0a41a46d69de01623d88c630c_GoodwillandIntangibleAssetsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_f8c58fbd-50bd-4b55-8d9d-ba39eae008a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_f8c58fbd-50bd-4b55-8d9d-ba39eae008a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_7586b4c6-3482-4b4e-a68d-cf31078e96c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_7586b4c6-3482-4b4e-a68d-cf31078e96c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityPayments_dac501ed-2889-453f-9454-7dc6d64dc2e5" xlink:href="vtrs-20220630.xsd#vtrs_BusinessCombinationContingentConsiderationLiabilityPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityPayments_dac501ed-2889-453f-9454-7dc6d64dc2e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_b46bc1ca-b40f-4f1a-bc98-5e1122e45db5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_b46bc1ca-b40f-4f1a-bc98-5e1122e45db5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2a85c7e3-f8b3-4526-b01f-93985b54afc6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_Goodwill_2a85c7e3-f8b3-4526-b01f-93985b54afc6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAmountOfFairValueInExcessOfCarryingAmount_d8f8456b-c6ea-4a59-a4b0-a9a7a778694b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReportingUnitAmountOfFairValueInExcessOfCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_ReportingUnitAmountOfFairValueInExcessOfCarryingAmount_d8f8456b-c6ea-4a59-a4b0-a9a7a778694b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_7b74ad59-14d7-4568-afca-c5b5c0d4789f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_ReportingUnitPercentageOfFairValueInExcessOfCarryingAmount_7b74ad59-14d7-4568-afca-c5b5c0d4789f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GoodwillImpairmentMeasurementInputTerm_d74f4f7a-b6da-4d20-942e-89d0e1b9dc43" xlink:href="vtrs-20220630.xsd#vtrs_GoodwillImpairmentMeasurementInputTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_vtrs_GoodwillImpairmentMeasurementInputTerm_d74f4f7a-b6da-4d20-942e-89d0e1b9dc43" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GoodwillImpairmentMeasurementInput_e6e96e77-801d-4cab-b264-c322d23d6d64" xlink:href="vtrs-20220630.xsd#vtrs_GoodwillImpairmentMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_vtrs_GoodwillImpairmentMeasurementInput_e6e96e77-801d-4cab-b264-c322d23d6d64" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GoodWillAfterAmortizationExpenseBeforeReclassification_19bcd7c9-3a23-4db2-b726-d56d46034386" xlink:href="vtrs-20220630.xsd#vtrs_GoodWillAfterAmortizationExpenseBeforeReclassification"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_vtrs_GoodWillAfterAmortizationExpenseBeforeReclassification_19bcd7c9-3a23-4db2-b726-d56d46034386" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_26253e02-38a4-48d6-8f4c-d606b5148daa" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitAxis_b86de899-42c1-4865-aa39-2146c601cc00" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReportingUnitAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_us-gaap_ReportingUnitAxis_b86de899-42c1-4865-aa39-2146c601cc00" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_b86de899-42c1-4865-aa39-2146c601cc00_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReportingUnitAxis_b86de899-42c1-4865-aa39-2146c601cc00" xlink:to="loc_us-gaap_ReportingUnitDomain_b86de899-42c1-4865-aa39-2146c601cc00_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReportingUnitDomain_2de8677c-94d8-4743-ba29-add1be6e497f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReportingUnitDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReportingUnitAxis_b86de899-42c1-4865-aa39-2146c601cc00" xlink:to="loc_us-gaap_ReportingUnitDomain_2de8677c-94d8-4743-ba29-add1be6e497f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EuropeSegmentMember_4e79dcb1-2fcf-4758-9ff2-f7c3a982f455" xlink:href="vtrs-20220630.xsd#vtrs_EuropeSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReportingUnitDomain_2de8677c-94d8-4743-ba29-add1be6e497f" xlink:to="loc_vtrs_EuropeSegmentMember_4e79dcb1-2fcf-4758-9ff2-f7c3a982f455" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_66978682-3f29-4a44-b4ac-1e106d97e206" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_srt_ConsolidationItemsAxis_66978682-3f29-4a44-b4ac-1e106d97e206" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_66978682-3f29-4a44-b4ac-1e106d97e206_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_66978682-3f29-4a44-b4ac-1e106d97e206" xlink:to="loc_srt_ConsolidationItemsDomain_66978682-3f29-4a44-b4ac-1e106d97e206_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_06b6a028-068b-4273-b46e-a9eb16be63ee" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_66978682-3f29-4a44-b4ac-1e106d97e206" xlink:to="loc_srt_ConsolidationItemsDomain_06b6a028-068b-4273-b46e-a9eb16be63ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_744cb450-21ad-4e9a-a1f5-be2d08e74a68" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_06b6a028-068b-4273-b46e-a9eb16be63ee" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_744cb450-21ad-4e9a-a1f5-be2d08e74a68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_495db164-4153-46d3-94f4-cacac22e458e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_495db164-4153-46d3-94f4-cacac22e458e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_495db164-4153-46d3-94f4-cacac22e458e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_495db164-4153-46d3-94f4-cacac22e458e" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_495db164-4153-46d3-94f4-cacac22e458e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1b39c75f-327e-485c-ac67-49d56537cc90" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_495db164-4153-46d3-94f4-cacac22e458e" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1b39c75f-327e-485c-ac67-49d56537cc90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_9d708e69-34b6-462e-8e33-8a543debeb51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_1b39c75f-327e-485c-ac67-49d56537cc90" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_9d708e69-34b6-462e-8e33-8a543debeb51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b486cedc-e95d-4453-842b-7a35be3e0cc4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_srt_RangeAxis_b486cedc-e95d-4453-842b-7a35be3e0cc4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b486cedc-e95d-4453-842b-7a35be3e0cc4_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_b486cedc-e95d-4453-842b-7a35be3e0cc4" xlink:to="loc_srt_RangeMember_b486cedc-e95d-4453-842b-7a35be3e0cc4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_24969416-222b-407b-b8c1-4e822e11f8e7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_b486cedc-e95d-4453-842b-7a35be3e0cc4" xlink:to="loc_srt_RangeMember_24969416-222b-407b-b8c1-4e822e11f8e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_7412e20c-1c57-4118-8379-d958a9dcb59d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_24969416-222b-407b-b8c1-4e822e11f8e7" xlink:to="loc_srt_MinimumMember_7412e20c-1c57-4118-8379-d958a9dcb59d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6a888da4-ce9c-4d08-b88f-eb523b1be6b2" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_24969416-222b-407b-b8c1-4e822e11f8e7" xlink:to="loc_srt_MaximumMember_6a888da4-ce9c-4d08-b88f-eb523b1be6b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_46a02158-3f8d-4c23-8a85-96b08091bd93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_46a02158-3f8d-4c23-8a85-96b08091bd93" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_46a02158-3f8d-4c23-8a85-96b08091bd93_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_46a02158-3f8d-4c23-8a85-96b08091bd93" xlink:to="loc_us-gaap_SegmentDomain_46a02158-3f8d-4c23-8a85-96b08091bd93_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_46a02158-3f8d-4c23-8a85-96b08091bd93" xlink:to="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EuropeSegmentMember_51043018-0d25-4e68-9818-c779d93e0889" xlink:href="vtrs-20220630.xsd#vtrs_EuropeSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:to="loc_vtrs_EuropeSegmentMember_51043018-0d25-4e68-9818-c779d93e0889" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_NorthAmericaSegmentMember_4e0240c4-35c4-49e8-986c-a2141636cd72" xlink:href="vtrs-20220630.xsd#vtrs_NorthAmericaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:to="loc_vtrs_NorthAmericaSegmentMember_4e0240c4-35c4-49e8-986c-a2141636cd72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EmergingMarketsSegmentMember_78bf3cae-dac8-4ee4-bd02-1bfc8e031c5d" xlink:href="vtrs-20220630.xsd#vtrs_EmergingMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:to="loc_vtrs_EmergingMarketsSegmentMember_78bf3cae-dac8-4ee4-bd02-1bfc8e031c5d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_3ae62cf1-8ee1-4fa1-abd2-9732dc28abbd" xlink:href="vtrs-20220630.xsd#vtrs_JapanAustraliaAndNewZealandSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:to="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_3ae62cf1-8ee1-4fa1-abd2-9732dc28abbd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GreaterChinaSegmentMember_017db0b7-6b33-4a7d-b689-3b75378f62a8" xlink:href="vtrs-20220630.xsd#vtrs_GreaterChinaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_86860aa6-d29f-4bed-921e-c66b370e8a9a" xlink:to="loc_vtrs_GreaterChinaSegmentMember_017db0b7-6b33-4a7d-b689-3b75378f62a8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueAxis_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_us-gaap_ValuationTechniqueAxis_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationTechniqueAxis_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107" xlink:to="loc_us-gaap_ValuationTechniqueDomain_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_dd9793e5-a101-4f86-8116-229cfcba8ac7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationTechniqueAxis_0b8d7d12-e848-4a9f-bb6a-c2bf6b367107" xlink:to="loc_us-gaap_ValuationTechniqueDomain_dd9793e5-a101-4f86-8116-229cfcba8ac7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDiscountedCashFlowMember_8f8912b0-15f2-4c63-b951-5eab681aa5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueDiscountedCashFlowMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationTechniqueDomain_dd9793e5-a101-4f86-8116-229cfcba8ac7" xlink:to="loc_us-gaap_ValuationTechniqueDiscountedCashFlowMember_8f8912b0-15f2-4c63-b951-5eab681aa5b3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_eb0536f8-0e29-442f-91d2-cdeae6dc22bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ce4b6ceb-814b-4a1b-a72d-ddc5845a3ce5" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_eb0536f8-0e29-442f-91d2-cdeae6dc22bd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_eb0536f8-0e29-442f-91d2-cdeae6dc22bd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_eb0536f8-0e29-442f-91d2-cdeae6dc22bd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_eb0536f8-0e29-442f-91d2-cdeae6dc22bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_eb0536f8-0e29-442f-91d2-cdeae6dc22bd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputLongTermRevenueGrowthRateMember_c491b0e0-48bc-4a5f-8d69-cfd177339151" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputLongTermRevenueGrowthRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_us-gaap_MeasurementInputLongTermRevenueGrowthRateMember_c491b0e0-48bc-4a5f-8d69-cfd177339151" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_MeasurementInputTerminalYearRevenueGrowthRateMember_4973e598-917c-435c-9afa-71479febb389" xlink:href="vtrs-20220630.xsd#vtrs_MeasurementInputTerminalYearRevenueGrowthRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_vtrs_MeasurementInputTerminalYearRevenueGrowthRateMember_4973e598-917c-435c-9afa-71479febb389" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_MeasurementInputEstimatedTaxRateMember_3c0948b2-67bf-462c-91ee-96d7365cc66c" xlink:href="vtrs-20220630.xsd#vtrs_MeasurementInputEstimatedTaxRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_vtrs_MeasurementInputEstimatedTaxRateMember_3c0948b2-67bf-462c-91ee-96d7365cc66c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputEbitdaMultipleMember_c6bbb3d7-ea45-4bdb-9878-0646fd5a3ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputEbitdaMultipleMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_us-gaap_MeasurementInputEbitdaMultipleMember_c6bbb3d7-ea45-4bdb-9878-0646fd5a3ffa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputControlPremiumMember_45bf2154-32af-445e-b3bf-a38f4b9345cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputControlPremiumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_us-gaap_MeasurementInputControlPremiumMember_45bf2154-32af-445e-b3bf-a38f4b9345cc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_MeasurementInputReductionInTerminalYearRevenueGrowthRateMember_714307b0-51f9-4cf7-9aff-253e713c2b86" xlink:href="vtrs-20220630.xsd#vtrs_MeasurementInputReductionInTerminalYearRevenueGrowthRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_vtrs_MeasurementInputReductionInTerminalYearRevenueGrowthRateMember_714307b0-51f9-4cf7-9aff-253e713c2b86" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_MeasurementInputIncreaseInDiscountRateMember_a9f5ec21-9238-4a55-871e-c7edc6571d96" xlink:href="vtrs-20220630.xsd#vtrs_MeasurementInputIncreaseInDiscountRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_vtrs_MeasurementInputIncreaseInDiscountRateMember_a9f5ec21-9238-4a55-871e-c7edc6571d96" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_d5058f5e-f2e9-47c0-8680-23cb0a0ef067" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_9b840e06-5207-4568-8e5f-efbcfa5e52b4" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_d5058f5e-f2e9-47c0-8680-23cb0a0ef067" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsChangesinCarryingAmountofGoodwillDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#GoodwillandIntangibleAssetsChangesinCarryingAmountofGoodwillDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsChangesinCarryingAmountofGoodwillDetails" xlink:type="extended" id="i1f81c8465f144d4eba9a31c2941dcceb_GoodwillandIntangibleAssetsChangesinCarryingAmountofGoodwillDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_dff8085c-2944-4e0a-ac80-8df51ef379ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_dff8085c-2944-4e0a-ac80-8df51ef379ab" xlink:to="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_b62c86c9-7618-461a-ba82-e4c4441b128f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:to="loc_us-gaap_GoodwillGross_b62c86c9-7618-461a-ba82-e4c4441b128f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_e778b5ac-4eea-4580-9dbc-71bd9aea04e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_e778b5ac-4eea-4580-9dbc-71bd9aea04e5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_6e59c3dd-d50f-4826-8d17-1776ca8b2d07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:to="loc_us-gaap_GoodwillTranslationAndPurchaseAccountingAdjustments_6e59c3dd-d50f-4826-8d17-1776ca8b2d07" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_088c107f-5242-497c-8a96-b3a7a2a7b421" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:to="loc_us-gaap_Goodwill_088c107f-5242-497c-8a96-b3a7a2a7b421" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_d018f4b2-194f-4555-a046-050ae512867f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillGross_50802a21-106a-45d3-99a6-59ccbfc61408" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_96ea7e93-17b1-4519-ad55-0996ab63e38c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillTransfers_fa95cfaf-1547-4e81-af5f-3c72a8db14f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GoodwillTransfers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_5d7ea718-af49-40c5-b26d-f21434c9acc8" xlink:to="loc_us-gaap_GoodwillTransfers_fa95cfaf-1547-4e81-af5f-3c72a8db14f1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_012abcde-d252-422c-adff-e6a5fc063768" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_dff8085c-2944-4e0a-ac80-8df51ef379ab" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_012abcde-d252-422c-adff-e6a5fc063768" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_af12184c-0a20-42c3-ae7e-d3df5427dce8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_012abcde-d252-422c-adff-e6a5fc063768" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_af12184c-0a20-42c3-ae7e-d3df5427dce8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_af12184c-0a20-42c3-ae7e-d3df5427dce8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_af12184c-0a20-42c3-ae7e-d3df5427dce8" xlink:to="loc_us-gaap_SegmentDomain_af12184c-0a20-42c3-ae7e-d3df5427dce8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_af12184c-0a20-42c3-ae7e-d3df5427dce8" xlink:to="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DevelopedMarketsSegmentMember_0055be32-2435-4709-bf83-54724a22c2b5" xlink:href="vtrs-20220630.xsd#vtrs_DevelopedMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:to="loc_vtrs_DevelopedMarketsSegmentMember_0055be32-2435-4709-bf83-54724a22c2b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GreaterChinaSegmentMember_99c02a2a-aac9-4c40-807d-6711e712c570" xlink:href="vtrs-20220630.xsd#vtrs_GreaterChinaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:to="loc_vtrs_GreaterChinaSegmentMember_99c02a2a-aac9-4c40-807d-6711e712c570" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_d1e82ed1-453c-4b0f-931d-cf4be139a975" xlink:href="vtrs-20220630.xsd#vtrs_JapanAustraliaAndNewZealandSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:to="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_d1e82ed1-453c-4b0f-931d-cf4be139a975" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EmergingMarketsSegmentMember_98649d5d-88de-45ef-a8e9-9d08f66e5f71" xlink:href="vtrs-20220630.xsd#vtrs_EmergingMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_ca5b111c-9839-4b94-a8b2-16d4bcdacfe7" xlink:to="loc_vtrs_EmergingMarketsSegmentMember_98649d5d-88de-45ef-a8e9-9d08f66e5f71" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_f2d33703-2e49-4cdd-8d09-53243c8d9899" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_012abcde-d252-422c-adff-e6a5fc063768" xlink:to="loc_srt_CounterpartyNameAxis_f2d33703-2e49-4cdd-8d09-53243c8d9899" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_f2d33703-2e49-4cdd-8d09-53243c8d9899_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_f2d33703-2e49-4cdd-8d09-53243c8d9899" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_f2d33703-2e49-4cdd-8d09-53243c8d9899_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d19c8d17-b43b-4973-beda-208876f8ae99" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_f2d33703-2e49-4cdd-8d09-53243c8d9899" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d19c8d17-b43b-4973-beda-208876f8ae99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BioconBiologicsMember_5c6ed00c-3a79-4c28-80c1-a13c1479916b" xlink:href="vtrs-20220630.xsd#vtrs_BioconBiologicsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d19c8d17-b43b-4973-beda-208876f8ae99" xlink:to="loc_vtrs_BioconBiologicsMember_5c6ed00c-3a79-4c28-80c1-a13c1479916b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="extended" id="i7bfe76501ac947098dbb759d88678eae_GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:href="vtrs-20220630.xsd#vtrs_IntangibleAssetsbyMajorClassLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_834e78f9-2388-4161-b50b-ea64e0546773" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_834e78f9-2388-4161-b50b-ea64e0546773" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_529dbcb6-a9a8-483e-b4db-b46628d7d931" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_529dbcb6-a9a8-483e-b4db-b46628d7d931" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_e803137b-78d1-4cc0-9074-95e55e183afc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_e803137b-78d1-4cc0-9074-95e55e183afc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ec87e196-46a5-4f4d-974d-62d533d5b47a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ec87e196-46a5-4f4d-974d-62d533d5b47a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ca6133ce-1005-4b5a-9ff4-977156410dc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_ca6133ce-1005-4b5a-9ff4-977156410dc3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_03ea1087-a685-4664-a05f-415ba5296a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_03ea1087-a685-4664-a05f-415ba5296a3c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_45d9ccdb-9b64-444b-b235-27138c44a03b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_45d9ccdb-9b64-444b-b235-27138c44a03b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_76bb4d8d-9ec4-48c4-bf23-01257000376b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_76bb4d8d-9ec4-48c4-bf23-01257000376b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleOfIntangibleAssetsByMajorClassTable_d2fb97fc-9581-4142-a61e-518854cd5d9b" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleOfIntangibleAssetsByMajorClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_vtrs_IntangibleAssetsbyMajorClassLineItems_c8838303-1c46-441f-8fdf-4a4a2c981bf5" xlink:to="loc_vtrs_ScheduleOfIntangibleAssetsByMajorClassTable_d2fb97fc-9581-4142-a61e-518854cd5d9b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_1098a337-fe7c-425a-8bdd-6f16d340d7c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_vtrs_ScheduleOfIntangibleAssetsByMajorClassTable_d2fb97fc-9581-4142-a61e-518854cd5d9b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_1098a337-fe7c-425a-8bdd-6f16d340d7c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1098a337-fe7c-425a-8bdd-6f16d340d7c8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_1098a337-fe7c-425a-8bdd-6f16d340d7c8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1098a337-fe7c-425a-8bdd-6f16d340d7c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d0c371b5-c782-4d41-8589-8f21d5d8d78d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_1098a337-fe7c-425a-8bdd-6f16d340d7c8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d0c371b5-c782-4d41-8589-8f21d5d8d78d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentsMember_99407750-82c0-437a-b15f-9073a4eed52c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PatentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d0c371b5-c782-4d41-8589-8f21d5d8d78d" xlink:to="loc_us-gaap_PatentsMember_99407750-82c0-437a-b15f-9073a4eed52c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementTables" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementTables"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementTables" xlink:type="extended" id="i73c499686f4c420d91ac6aa8ce65c25a_FinancialInstrumentsandRiskManagementTables">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_cdfe7503-7234-43e3-bd41-844464859c46" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTextBlock_b091b8af-d364-4951-99be-4872450f3eee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_cdfe7503-7234-43e3-bd41-844464859c46" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTextBlock_b091b8af-d364-4951-99be-4872450f3eee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_a4e6b22e-02fd-4eba-aef7-3a5dbdb0125d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_cdfe7503-7234-43e3-bd41-844464859c46" xlink:to="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_a4e6b22e-02fd-4eba-aef7-3a5dbdb0125d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_4ba529ca-a2df-480c-ad01-630be0a75eec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_cdfe7503-7234-43e3-bd41-844464859c46" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_4ba529ca-a2df-480c-ad01-630be0a75eec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_bc26a20f-8de3-4b8c-adca-a0a8ef502506" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_cdfe7503-7234-43e3-bd41-844464859c46" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_bc26a20f-8de3-4b8c-adca-a0a8ef502506" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_33961781-5436-4224-be7a-946695cf1c94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_bc26a20f-8de3-4b8c-adca-a0a8ef502506" xlink:to="loc_us-gaap_HedgingDesignationAxis_33961781-5436-4224-be7a-946695cf1c94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_33961781-5436-4224-be7a-946695cf1c94_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_33961781-5436-4224-be7a-946695cf1c94" xlink:to="loc_us-gaap_HedgingDesignationDomain_33961781-5436-4224-be7a-946695cf1c94_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_c5ec358e-4945-4955-b98b-3438bdbbd9af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_33961781-5436-4224-be7a-946695cf1c94" xlink:to="loc_us-gaap_HedgingDesignationDomain_c5ec358e-4945-4955-b98b-3438bdbbd9af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_73e39776-f727-4bac-92c7-7b021c36fb6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_c5ec358e-4945-4955-b98b-3438bdbbd9af" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_73e39776-f727-4bac-92c7-7b021c36fb6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_d3e78619-1d04-4081-8b30-79c732798efd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_c5ec358e-4945-4955-b98b-3438bdbbd9af" xlink:to="loc_us-gaap_NondesignatedMember_d3e78619-1d04-4081-8b30-79c732798efd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_62732831-d1ae-4220-94c2-e89b22258b80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_bc26a20f-8de3-4b8c-adca-a0a8ef502506" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_62732831-d1ae-4220-94c2-e89b22258b80" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_62732831-d1ae-4220-94c2-e89b22258b80_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_62732831-d1ae-4220-94c2-e89b22258b80" xlink:to="loc_us-gaap_HedgingRelationshipDomain_62732831-d1ae-4220-94c2-e89b22258b80_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_a2cd28a3-a4a3-4e8f-84b5-93839c7f5424" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_62732831-d1ae-4220-94c2-e89b22258b80" xlink:to="loc_us-gaap_HedgingRelationshipDomain_a2cd28a3-a4a3-4e8f-84b5-93839c7f5424" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_76e01aac-fa5e-4dc0-989a-2ef34374cfa7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_a2cd28a3-a4a3-4e8f-84b5-93839c7f5424" xlink:to="loc_us-gaap_CashFlowHedgingMember_76e01aac-fa5e-4dc0-989a-2ef34374cfa7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_5a1e611b-42a2-4616-91f6-e24b76a4d28b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_a2cd28a3-a4a3-4e8f-84b5-93839c7f5424" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_5a1e611b-42a2-4616-91f6-e24b76a4d28b" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementNarrativeDetails" xlink:type="extended" id="i727cffb758e64b759d960aa9c5dcac43_FinancialInstrumentsandRiskManagementNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities_810c5ac6-c7c2-4cbf-8654-7dc34c88c482" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities_810c5ac6-c7c2-4cbf-8654-7dc34c88c482" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_ceb7aebc-05b3-496b-8f63-3a1b7e1cfa6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_ceb7aebc-05b3-496b-8f63-3a1b7e1cfa6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetNotionalAmount_f843d483-e141-4eff-94f7-af9f2ea7912e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeAssetNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_DerivativeAssetNotionalAmount_f843d483-e141-4eff-94f7-af9f2ea7912e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_59b8b19d-06a7-4c91-9a11-1bf10e80faf5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_LongTermDebt_59b8b19d-06a7-4c91-9a11-1bf10e80faf5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_fc953af0-ea97-49bd-bbd8-b31f98ee2d85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_fc953af0-ea97-49bd-bbd8-b31f98ee2d85" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_495fd159-59d4-496c-887b-6accf2622f6d" xlink:to="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_72c570dd-fa94-4cf8-8958-30d090d7fd4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_72c570dd-fa94-4cf8-8958-30d090d7fd4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_72c570dd-fa94-4cf8-8958-30d090d7fd4d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_72c570dd-fa94-4cf8-8958-30d090d7fd4d" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_72c570dd-fa94-4cf8-8958-30d090d7fd4d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_d602ae12-6ab6-4744-ab52-ee72a9b1e4a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_72c570dd-fa94-4cf8-8958-30d090d7fd4d" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_d602ae12-6ab6-4744-ab52-ee72a9b1e4a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_ec5b9bb4-9e16-4ab7-95a6-40ece4464ab9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d602ae12-6ab6-4744-ab52-ee72a9b1e4a9" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_ec5b9bb4-9e16-4ab7-95a6-40ece4464ab9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_5f170b10-44df-47ce-a9da-e793466bc538" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_5f170b10-44df-47ce-a9da-e793466bc538" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_5f170b10-44df-47ce-a9da-e793466bc538_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_5f170b10-44df-47ce-a9da-e793466bc538" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_5f170b10-44df-47ce-a9da-e793466bc538_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_34c4917f-7404-4ca7-a65c-b69c5d51eba4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_5f170b10-44df-47ce-a9da-e793466bc538" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_34c4917f-7404-4ca7-a65c-b69c5d51eba4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_82133827-3af1-4b76-bd5a-10b550ddc27b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_34c4917f-7404-4ca7-a65c-b69c5d51eba4" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_82133827-3af1-4b76-bd5a-10b550ddc27b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_47ce89bd-b4e2-4259-b11b-a0784b136a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_34c4917f-7404-4ca7-a65c-b69c5d51eba4" xlink:to="loc_us-gaap_InterestRateSwapMember_47ce89bd-b4e2-4259-b11b-a0784b136a5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_24b388b6-ebe1-4786-9a30-4aa2e31c24f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_24b388b6-ebe1-4786-9a30-4aa2e31c24f5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_24b388b6-ebe1-4786-9a30-4aa2e31c24f5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_24b388b6-ebe1-4786-9a30-4aa2e31c24f5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_24b388b6-ebe1-4786-9a30-4aa2e31c24f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_8f40aaaf-c7c4-4ce3-bbed-6d2acb887b31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_24b388b6-ebe1-4786-9a30-4aa2e31c24f5" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_8f40aaaf-c7c4-4ce3-bbed-6d2acb887b31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherExpenseMember_6061aba0-12cb-42aa-9854-942b38ec08d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_8f40aaaf-c7c4-4ce3-bbed-6d2acb887b31" xlink:to="loc_us-gaap_OtherExpenseMember_6061aba0-12cb-42aa-9854-942b38ec08d7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_203e38f6-a646-425e-b502-e7aaadf9f3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_us-gaap_DebtInstrumentAxis_203e38f6-a646-425e-b502-e7aaadf9f3c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_203e38f6-a646-425e-b502-e7aaadf9f3c8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_203e38f6-a646-425e-b502-e7aaadf9f3c8" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_203e38f6-a646-425e-b502-e7aaadf9f3c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_203e38f6-a646-425e-b502-e7aaadf9f3c8" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2024EuroSeniorNotesMember_6201c265-a231-4aa5-8fca-e8c4e7e09773" xlink:href="vtrs-20220630.xsd#vtrs_A2024EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2024EuroSeniorNotesMember_6201c265-a231-4aa5-8fca-e8c4e7e09773" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2028EuroSeniorNotesMember_a3d8eb35-21bf-4e43-a689-909d3720d352" xlink:href="vtrs-20220630.xsd#vtrs_A2028EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2028EuroSeniorNotesMember_a3d8eb35-21bf-4e43-a689-909d3720d352" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2020EuroSeniorNotesMember_413bd65f-380b-45cb-b94e-280c6a0c20cb" xlink:href="vtrs-20220630.xsd#vtrs_A2020EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2020EuroSeniorNotesMember_413bd65f-380b-45cb-b94e-280c6a0c20cb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2025EuroSeniorNotesMember_d9991eb4-8803-4537-a413-085ec01c080b" xlink:href="vtrs-20220630.xsd#vtrs_A2025EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2025EuroSeniorNotesMember_d9991eb4-8803-4537-a413-085ec01c080b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2022EuroSeniorNotesMember_ee5bbf56-d2f2-4304-b60d-251ff6eb7be5" xlink:href="vtrs-20220630.xsd#vtrs_A2022EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2022EuroSeniorNotesMember_ee5bbf56-d2f2-4304-b60d-251ff6eb7be5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2024EuroSeniorNotes1023Member_9c0d7f5e-45aa-437a-8341-2d28fd478ae0" xlink:href="vtrs-20220630.xsd#vtrs_A2024EuroSeniorNotes1023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2024EuroSeniorNotes1023Member_9c0d7f5e-45aa-437a-8341-2d28fd478ae0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2027EuroSeniorNotesMember_68daf65e-a328-4475-a418-85a0b667e07c" xlink:href="vtrs-20220630.xsd#vtrs_A2027EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2027EuroSeniorNotesMember_68daf65e-a328-4475-a418-85a0b667e07c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2032EuroSeniorNotesMember_ff62ed16-aba2-4598-9f88-0cb37c2a3fa7" xlink:href="vtrs-20220630.xsd#vtrs_A2032EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_A2032EuroSeniorNotesMember_ff62ed16-aba2-4598-9f88-0cb37c2a3fa7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_YENTermLoanMember_52c82a8b-9c6a-497d-88e2-78c9e7ea8c4c" xlink:href="vtrs-20220630.xsd#vtrs_YENTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ad412a1-ccbf-4a92-b485-0b909b9d0ebf" xlink:to="loc_vtrs_YENTermLoanMember_52c82a8b-9c6a-497d-88e2-78c9e7ea8c4c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_09e5e69a-4703-47eb-a447-d1197600ff60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_09e5e69a-4703-47eb-a447-d1197600ff60" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_09e5e69a-4703-47eb-a447-d1197600ff60_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_09e5e69a-4703-47eb-a447-d1197600ff60" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_09e5e69a-4703-47eb-a447-d1197600ff60_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_f37f5cee-5044-4509-bd7e-9930b1556253" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_09e5e69a-4703-47eb-a447-d1197600ff60" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_f37f5cee-5044-4509-bd7e-9930b1556253" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ContingentConsiderationMember_f646e98f-91ac-4469-8ccc-8b930667650b" xlink:href="vtrs-20220630.xsd#vtrs_ContingentConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f37f5cee-5044-4509-bd7e-9930b1556253" xlink:to="loc_vtrs_ContingentConsiderationMember_f646e98f-91ac-4469-8ccc-8b930667650b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_6f8b0c62-fb44-4ee1-b995-e1aaf0b9fe7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f37f5cee-5044-4509-bd7e-9930b1556253" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_6f8b0c62-fb44-4ee1-b995-e1aaf0b9fe7a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_3d98a052-8e38-4452-bae7-f050d8059f80" xlink:to="loc_srt_RangeAxis_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b" xlink:to="loc_srt_RangeMember_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_471ea2ac-5b18-47fc-8369-e6fab075dacd" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_60c97dd6-7a2c-4ea4-914e-a3eb8dd8241b" xlink:to="loc_srt_RangeMember_471ea2ac-5b18-47fc-8369-e6fab075dacd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_1074103d-15c4-42b1-97dc-3254b022225a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_471ea2ac-5b18-47fc-8369-e6fab075dacd" xlink:to="loc_srt_MinimumMember_1074103d-15c4-42b1-97dc-3254b022225a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_8afe3f67-6824-42e4-8195-334e542f36c7" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_471ea2ac-5b18-47fc-8369-e6fab075dacd" xlink:to="loc_srt_MaximumMember_8afe3f67-6824-42e4-8195-334e542f36c7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValueofDerivativeInstrumentsDerivativesDesignatedAsHedgingInstrumentsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValueofDerivativeInstrumentsDerivativesDesignatedAsHedgingInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValueofDerivativeInstrumentsDerivativesDesignatedAsHedgingInstrumentsDetails" xlink:type="extended" id="i6ccfa8441546485f937e9f1c46730d43_FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValueofDerivativeInstrumentsDerivativesDesignatedAsHedgingInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_4f57258f-e917-4ec0-9050-6bb7a059e7a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_71d4bae2-f9b1-4056-8503-da6c3b2b83e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_4f57258f-e917-4ec0-9050-6bb7a059e7a8" xlink:to="loc_us-gaap_ScheduleOfDerivativeInstrumentsInStatementOfFinancialPositionFairValueTextBlock_71d4bae2-f9b1-4056-8503-da6c3b2b83e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_3c766cf1-fbc5-473d-ae8b-2dca8c25faa9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_4f57258f-e917-4ec0-9050-6bb7a059e7a8" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_3c766cf1-fbc5-473d-ae8b-2dca8c25faa9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_1681ea8b-0dff-4568-887d-4051a6d3e6e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_4f57258f-e917-4ec0-9050-6bb7a059e7a8" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_1681ea8b-0dff-4568-887d-4051a6d3e6e7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_dc6e2718-8f21-4e65-8d92-d155939587b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_4f57258f-e917-4ec0-9050-6bb7a059e7a8" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_dc6e2718-8f21-4e65-8d92-d155939587b1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_dc6e2718-8f21-4e65-8d92-d155939587b1" xlink:to="loc_us-gaap_HedgingDesignationAxis_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2" xlink:to="loc_us-gaap_HedgingDesignationDomain_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_211e7046-1441-4108-ba4e-1cd821bdb3d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_8bd877ce-a378-4129-a5d0-2b5bbb68d6e2" xlink:to="loc_us-gaap_HedgingDesignationDomain_211e7046-1441-4108-ba4e-1cd821bdb3d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_c74fb06a-4cb6-43fb-b78a-41a0a981d997" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_211e7046-1441-4108-ba4e-1cd821bdb3d7" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_c74fb06a-4cb6-43fb-b78a-41a0a981d997" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_c4c56951-fac2-428a-94fb-a1d646215df0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_211e7046-1441-4108-ba4e-1cd821bdb3d7" xlink:to="loc_us-gaap_NondesignatedMember_c4c56951-fac2-428a-94fb-a1d646215df0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_1d8af003-3488-4217-884a-0c73597312fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_dc6e2718-8f21-4e65-8d92-d155939587b1" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_1d8af003-3488-4217-884a-0c73597312fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_1d8af003-3488-4217-884a-0c73597312fb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1d8af003-3488-4217-884a-0c73597312fb" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_1d8af003-3488-4217-884a-0c73597312fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_f51fa75f-ab11-4b7a-91fc-6efb31b8aec6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_1d8af003-3488-4217-884a-0c73597312fb" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_f51fa75f-ab11-4b7a-91fc-6efb31b8aec6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_292e6d7a-2031-47a6-be60-41dc37ecb2af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f51fa75f-ab11-4b7a-91fc-6efb31b8aec6" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_292e6d7a-2031-47a6-be60-41dc37ecb2af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_fed747d0-0265-4381-8067-faaa5540fd8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f51fa75f-ab11-4b7a-91fc-6efb31b8aec6" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_fed747d0-0265-4381-8067-faaa5540fd8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_dc6e2718-8f21-4e65-8d92-d155939587b1" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_e6a0bc1f-8a92-4bfe-a011-a44b75d3181b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bc4aa5b7-3c61-46d8-9d9f-0e90d54f26c6" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_e6a0bc1f-8a92-4bfe-a011-a44b75d3181b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_c730c2d7-a3c0-4d87-8005-36b2514a7baf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e6a0bc1f-8a92-4bfe-a011-a44b75d3181b" xlink:to="loc_us-gaap_InterestRateSwapMember_c730c2d7-a3c0-4d87-8005-36b2514a7baf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_f39233b7-e748-4055-ac43-1840b46b30b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e6a0bc1f-8a92-4bfe-a011-a44b75d3181b" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_f39233b7-e748-4055-ac43-1840b46b30b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_0b089366-bb33-4335-bbc5-aa02b20b5dde" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e6a0bc1f-8a92-4bfe-a011-a44b75d3181b" xlink:to="loc_us-gaap_ForeignExchangeContractMember_0b089366-bb33-4335-bbc5-aa02b20b5dde" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValuesofDerivativeInstrumentsDerivativesNotDesignatedAsHedgingInstrumentDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValuesofDerivativeInstrumentsDerivativesNotDesignatedAsHedgingInstrumentDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValuesofDerivativeInstrumentsDerivativesNotDesignatedAsHedgingInstrumentDetails" xlink:type="extended" id="i2b8a46141251419bb80ba5e805e02772_FinancialInstrumentsandRiskManagementEffectofDerivativeInstrumentsontheCondensedConsolidatedBalanceSheetsFairValuesofDerivativeInstrumentsDerivativesNotDesignatedAsHedgingInstrumentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_19cd8e9e-e683-4cf4-9ed2-16e5ccdeabca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1ecd68d2-2eb0-4c2a-afbb-ec28ec76b2f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_19cd8e9e-e683-4cf4-9ed2-16e5ccdeabca" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1ecd68d2-2eb0-4c2a-afbb-ec28ec76b2f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4521b447-3836-4965-b2e5-5bc3695bbe04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_19cd8e9e-e683-4cf4-9ed2-16e5ccdeabca" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_4521b447-3836-4965-b2e5-5bc3695bbe04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_14ac6e47-8a78-4578-ba0f-72c4c5e84ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_19cd8e9e-e683-4cf4-9ed2-16e5ccdeabca" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_14ac6e47-8a78-4578-ba0f-72c4c5e84ffa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_103185be-2ecd-4878-8ca8-05fa2967ffa3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_14ac6e47-8a78-4578-ba0f-72c4c5e84ffa" xlink:to="loc_us-gaap_HedgingDesignationAxis_103185be-2ecd-4878-8ca8-05fa2967ffa3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_103185be-2ecd-4878-8ca8-05fa2967ffa3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_103185be-2ecd-4878-8ca8-05fa2967ffa3" xlink:to="loc_us-gaap_HedgingDesignationDomain_103185be-2ecd-4878-8ca8-05fa2967ffa3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_489e3705-657e-408d-9774-9de44a46c0d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_103185be-2ecd-4878-8ca8-05fa2967ffa3" xlink:to="loc_us-gaap_HedgingDesignationDomain_489e3705-657e-408d-9774-9de44a46c0d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_252808b0-dcfe-423e-88a1-858e0b62fa3f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_489e3705-657e-408d-9774-9de44a46c0d5" xlink:to="loc_us-gaap_NondesignatedMember_252808b0-dcfe-423e-88a1-858e0b62fa3f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_3638042c-ca90-4ceb-ad1f-0517a31ee71c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_14ac6e47-8a78-4578-ba0f-72c4c5e84ffa" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_3638042c-ca90-4ceb-ad1f-0517a31ee71c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_3638042c-ca90-4ceb-ad1f-0517a31ee71c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3638042c-ca90-4ceb-ad1f-0517a31ee71c" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_3638042c-ca90-4ceb-ad1f-0517a31ee71c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_380ea258-5c62-49e0-8bf2-95ee4861c1bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3638042c-ca90-4ceb-ad1f-0517a31ee71c" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_380ea258-5c62-49e0-8bf2-95ee4861c1bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_577c2497-ebf6-44cb-b39f-237c8c06b1a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_380ea258-5c62-49e0-8bf2-95ee4861c1bf" xlink:to="loc_us-gaap_PrepaidExpensesAndOtherCurrentAssetsMember_577c2497-ebf6-44cb-b39f-237c8c06b1a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_90db94f5-8f12-4610-bafd-2dc67275fc44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_380ea258-5c62-49e0-8bf2-95ee4861c1bf" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_90db94f5-8f12-4610-bafd-2dc67275fc44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_25db5ce8-c891-47af-81c4-8224bfd15655" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_14ac6e47-8a78-4578-ba0f-72c4c5e84ffa" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_25db5ce8-c891-47af-81c4-8224bfd15655" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_25db5ce8-c891-47af-81c4-8224bfd15655_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_25db5ce8-c891-47af-81c4-8224bfd15655" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_25db5ce8-c891-47af-81c4-8224bfd15655_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_d5cb3197-b19b-42c1-a92f-792e348e2093" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_25db5ce8-c891-47af-81c4-8224bfd15655" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_d5cb3197-b19b-42c1-a92f-792e348e2093" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_201f264a-0ed5-432f-a0fa-0812fafcb1e5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_d5cb3197-b19b-42c1-a92f-792e348e2093" xlink:to="loc_us-gaap_ForeignExchangeContractMember_201f264a-0ed5-432f-a0fa-0812fafcb1e5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinFairValueHedgingRelationshipsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinFairValueHedgingRelationshipsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinFairValueHedgingRelationshipsDetails" xlink:type="extended" id="i3237a9175c8e40afae588ae9d019cf3d_FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinFairValueHedgingRelationshipsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_78f62a04-aa1a-4e0b-a588-fa0dcab6e98d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_662fd346-d698-41f7-8ef5-d1888e28af3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_78f62a04-aa1a-4e0b-a588-fa0dcab6e98d" xlink:to="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_662fd346-d698-41f7-8ef5-d1888e28af3a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_27e04108-e366-4193-aa0a-d7fe035cef10" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_78f62a04-aa1a-4e0b-a588-fa0dcab6e98d" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_27e04108-e366-4193-aa0a-d7fe035cef10" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_3847b191-0c98-4047-9449-50b5e067b93d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_27e04108-e366-4193-aa0a-d7fe035cef10" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_3847b191-0c98-4047-9449-50b5e067b93d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_3847b191-0c98-4047-9449-50b5e067b93d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_3847b191-0c98-4047-9449-50b5e067b93d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_3847b191-0c98-4047-9449-50b5e067b93d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_1f9f8d2e-127a-4a5b-abaf-6b4993df7032" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_3847b191-0c98-4047-9449-50b5e067b93d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_1f9f8d2e-127a-4a5b-abaf-6b4993df7032" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_fa2142c4-1de9-4274-b974-6c3eb8ec89c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_27e04108-e366-4193-aa0a-d7fe035cef10" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_fa2142c4-1de9-4274-b974-6c3eb8ec89c8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_fa2142c4-1de9-4274-b974-6c3eb8ec89c8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_fa2142c4-1de9-4274-b974-6c3eb8ec89c8" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_fa2142c4-1de9-4274-b974-6c3eb8ec89c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_2d019bda-7cb2-4d86-8a38-8ec757cc74b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_fa2142c4-1de9-4274-b974-6c3eb8ec89c8" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_2d019bda-7cb2-4d86-8a38-8ec757cc74b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseMember_7064b9c2-b4e3-47ab-ba8c-ebe3bf1d5787" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_2d019bda-7cb2-4d86-8a38-8ec757cc74b6" xlink:to="loc_us-gaap_InterestExpenseMember_7064b9c2-b4e3-47ab-ba8c-ebe3bf1d5787" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_cadec663-8371-4baf-a399-d7af839a06dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_27e04108-e366-4193-aa0a-d7fe035cef10" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_cadec663-8371-4baf-a399-d7af839a06dc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_cadec663-8371-4baf-a399-d7af839a06dc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cadec663-8371-4baf-a399-d7af839a06dc" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_cadec663-8371-4baf-a399-d7af839a06dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_29a6d5a3-1f28-43ef-95d5-6265dd224745" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cadec663-8371-4baf-a399-d7af839a06dc" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_29a6d5a3-1f28-43ef-95d5-6265dd224745" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_c3840e62-0235-4525-9025-fc923e8d0fdc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_29a6d5a3-1f28-43ef-95d5-6265dd224745" xlink:to="loc_us-gaap_InterestRateSwapMember_c3840e62-0235-4525-9025-fc923e8d0fdc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember_e32d58d3-9bc8-406b-b64e-0126c72d77eb" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_29a6d5a3-1f28-43ef-95d5-6265dd224745" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember_e32d58d3-9bc8-406b-b64e-0126c72d77eb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinCashFlowHedgingRelationshipsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinCashFlowHedgingRelationshipsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinCashFlowHedgingRelationshipsDetails" xlink:type="extended" id="i22139e08e90d431eacb61b6434b9407b_FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesinCashFlowHedgingRelationshipsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet_6ae3c3a2-94e7-44fc-96e3-b4bceba9c109" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet_6ae3c3a2-94e7-44fc-96e3-b4bceba9c109" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_81f44393-bf4f-4f08-a2f2-2c0879987abe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_81f44393-bf4f-4f08-a2f2-2c0879987abe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_26a0b961-678a-49e0-b029-4162c856c9e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_26a0b961-678a-49e0-b029-4162c856c9e1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_f7eb2df3-75e1-4505-8af0-c2b42832eb7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_f7eb2df3-75e1-4505-8af0-c2b42832eb7b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_37eed40b-df41-49ad-80c4-23e04ba9002b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_37eed40b-df41-49ad-80c4-23e04ba9002b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_e45ac96e-7b39-42f7-a47f-7bd07b11b397" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_e45ac96e-7b39-42f7-a47f-7bd07b11b397" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_474af25c-d6a8-41c5-bb75-defca02bb078" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_e323e1a9-9655-4ed9-b15a-212390facf2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_e323e1a9-9655-4ed9-b15a-212390facf2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_e323e1a9-9655-4ed9-b15a-212390facf2d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_e323e1a9-9655-4ed9-b15a-212390facf2d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_e323e1a9-9655-4ed9-b15a-212390facf2d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_a17cefb8-b3f1-45c3-b499-d2f41c607779" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_e323e1a9-9655-4ed9-b15a-212390facf2d" xlink:to="loc_us-gaap_HedgingRelationshipDomain_a17cefb8-b3f1-45c3-b499-d2f41c607779" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_671f69aa-6134-4891-933b-f784f866771f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_a17cefb8-b3f1-45c3-b499-d2f41c607779" xlink:to="loc_us-gaap_CashFlowHedgingMember_671f69aa-6134-4891-933b-f784f866771f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_1c900584-0d08-42d9-b442-b4bca03abe89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_a17cefb8-b3f1-45c3-b499-d2f41c607779" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_1c900584-0d08-42d9-b442-b4bca03abe89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_4eab0408-0e30-46a4-b788-ed868c836a13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_750f7fcd-4574-4c99-a54d-9fefa2a2f2f4" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_4eab0408-0e30-46a4-b788-ed868c836a13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_028a292c-23ac-4ca9-98cd-e71d73f3a304" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4eab0408-0e30-46a4-b788-ed868c836a13" xlink:to="loc_us-gaap_ForeignExchangeContractMember_028a292c-23ac-4ca9-98cd-e71d73f3a304" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_2d46f67d-3d9f-4bce-acdf-d0cf0be315a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4eab0408-0e30-46a4-b788-ed868c836a13" xlink:to="loc_us-gaap_InterestRateSwapMember_2d46f67d-3d9f-4bce-acdf-d0cf0be315a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_94003f28-bb88-4314-bda3-130e3dcfa6fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_94003f28-bb88-4314-bda3-130e3dcfa6fe" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_94003f28-bb88-4314-bda3-130e3dcfa6fe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_94003f28-bb88-4314-bda3-130e3dcfa6fe" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_94003f28-bb88-4314-bda3-130e3dcfa6fe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_f292c4e8-baa2-47a0-9db4-50258d589250" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_94003f28-bb88-4314-bda3-130e3dcfa6fe" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_f292c4e8-baa2-47a0-9db4-50258d589250" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesMember_eae9ca78-288a-459c-b1f4-6d66cff9b20d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f292c4e8-baa2-47a0-9db4-50258d589250" xlink:to="loc_us-gaap_SalesMember_eae9ca78-288a-459c-b1f4-6d66cff9b20d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseMember_334e003d-0b37-4415-941b-d3e7d4082710" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f292c4e8-baa2-47a0-9db4-50258d589250" xlink:to="loc_us-gaap_InterestExpenseMember_334e003d-0b37-4415-941b-d3e7d4082710" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherExpenseMember_75236bee-25b5-4cd6-8731-7c55e0660c1d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_f292c4e8-baa2-47a0-9db4-50258d589250" xlink:to="loc_us-gaap_OtherExpenseMember_75236bee-25b5-4cd6-8731-7c55e0660c1d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueAxis_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:to="loc_us-gaap_ValuationTechniqueAxis_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationTechniqueAxis_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc" xlink:to="loc_us-gaap_ValuationTechniqueDomain_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_45dc664b-0d9d-4460-aebd-20982540447d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationTechniqueAxis_8e5ad10e-ccb1-4ea9-87ff-36186d6094dc" xlink:to="loc_us-gaap_ValuationTechniqueDomain_45dc664b-0d9d-4460-aebd-20982540447d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_e88b275a-5ed0-401f-adcf-09b05a659b3a" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade" xlink:to="loc_us-gaap_EquityComponentDomain_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_61cd9651-958a-47aa-98ee-b11fbd5c9631" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_7e011bc8-7536-4524-b3cd-a9f2bd1b2ade" xlink:to="loc_us-gaap_EquityComponentDomain_61cd9651-958a-47aa-98ee-b11fbd5c9631" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_a91f1d90-b8b2-47fc-967b-036e1f695440" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_61cd9651-958a-47aa-98ee-b11fbd5c9631" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_a91f1d90-b8b2-47fc-967b-036e1f695440" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesNotDesignatedasHedgingInstrumentsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesNotDesignatedasHedgingInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesNotDesignatedasHedgingInstrumentsDetails" xlink:type="extended" id="iaa707cff3c5649c5bcd3dff322a8ef52_FinancialInstrumentsandRiskManagementEffectOfDerivativeInstrumentsontheCondensedConsolidatedStatementsofOperationsDerivativesNotDesignatedasHedgingInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_a70c0f7d-589a-47e2-a44c-c92526b10c43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_385fa55d-8fbe-4e31-8336-1165bee147a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_a70c0f7d-589a-47e2-a44c-c92526b10c43" xlink:to="loc_us-gaap_DerivativeInstrumentsNotDesignatedAsHedgingInstrumentsGainLossNet_385fa55d-8fbe-4e31-8336-1165bee147a0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2c7ab45d-cf97-471d-9332-3ac80b8b1125" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_a70c0f7d-589a-47e2-a44c-c92526b10c43" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2c7ab45d-cf97-471d-9332-3ac80b8b1125" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_8a7655be-1719-467b-8a9f-175d4d07f254" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2c7ab45d-cf97-471d-9332-3ac80b8b1125" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_8a7655be-1719-467b-8a9f-175d4d07f254" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8a7655be-1719-467b-8a9f-175d4d07f254_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_8a7655be-1719-467b-8a9f-175d4d07f254" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8a7655be-1719-467b-8a9f-175d4d07f254_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_11e8f0fd-d6bb-4633-8474-b88a627842e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_8a7655be-1719-467b-8a9f-175d4d07f254" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_11e8f0fd-d6bb-4633-8474-b88a627842e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_ba1fa379-4b54-45b3-b5da-7ceaeaf7a0c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_11e8f0fd-d6bb-4633-8474-b88a627842e2" xlink:to="loc_us-gaap_ForeignExchangeContractMember_ba1fa379-4b54-45b3-b5da-7ceaeaf7a0c8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_d542e7e1-e301-4862-8e0d-45383a5873ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_2c7ab45d-cf97-471d-9332-3ac80b8b1125" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_d542e7e1-e301-4862-8e0d-45383a5873ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_d542e7e1-e301-4862-8e0d-45383a5873ed_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d542e7e1-e301-4862-8e0d-45383a5873ed" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_d542e7e1-e301-4862-8e0d-45383a5873ed_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_9d6cf2fe-0e7c-4e8e-9695-40abf4a8e6f2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_d542e7e1-e301-4862-8e0d-45383a5873ed" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_9d6cf2fe-0e7c-4e8e-9695-40abf4a8e6f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherExpenseMember_ffb98ad2-1f30-404a-8a44-e652e31e0dfd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_9d6cf2fe-0e7c-4e8e-9695-40abf4a8e6f2" xlink:to="loc_us-gaap_OtherExpenseMember_ffb98ad2-1f30-404a-8a44-e652e31e0dfd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementFinancialAssetsandLiabilitiesCarriedatFairValueDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementFinancialAssetsandLiabilitiesCarriedatFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementFinancialAssetsandLiabilitiesCarriedatFairValueDetails" xlink:type="extended" id="ibe12e7ee5a9d4ac9af2b31e20fd6b768_FinancialInstrumentsandRiskManagementFinancialAssetsandLiabilitiesCarriedatFairValueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_26081093-a759-460a-b85a-40aaeaedd43a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_26081093-a759-460a-b85a-40aaeaedd43a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_4481ebfb-c2e1-42be-982e-337abbb48438" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TradingSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_TradingSecurities_4481ebfb-c2e1-42be-982e-337abbb48438" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_45e11cf9-c015-4db2-ae54-01b2a37efe96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_45e11cf9-c015-4db2-ae54-01b2a37efe96" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_3e67ab43-4214-4535-a0e8-70ae6231b8ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignCurrencyContractAssetFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_ForeignCurrencyContractAssetFairValueDisclosure_3e67ab43-4214-4535-a0e8-70ae6231b8ba" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_1a24c1ea-4507-4b27-963d-843fa10ab1b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_1a24c1ea-4507-4b27-963d-843fa10ab1b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_a5a5a043-8899-4665-b17f-b8254afc0395" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_a5a5a043-8899-4665-b17f-b8254afc0395" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_b98d8991-e01a-47b5-bcad-8538628bfc86" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_ForeignCurrencyContractsLiabilityFairValueDisclosure_b98d8991-e01a-47b5-bcad-8538628bfc86" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_be472269-378a-4206-bb09-63c1f8b57086" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_be472269-378a-4206-bb09-63c1f8b57086" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_6c66b81b-1e54-447a-8e47-ecaa9066b1ba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_6c66b81b-1e54-447a-8e47-ecaa9066b1ba" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_6086db80-0bce-422e-a592-91623d3f48dc" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_4abf3152-368c-4088-9cb0-02cdd083b7b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_4abf3152-368c-4088-9cb0-02cdd083b7b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_4abf3152-368c-4088-9cb0-02cdd083b7b5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_4abf3152-368c-4088-9cb0-02cdd083b7b5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_4abf3152-368c-4088-9cb0-02cdd083b7b5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_18f218a1-727b-4a66-8c13-54c22eff8dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_4abf3152-368c-4088-9cb0-02cdd083b7b5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_18f218a1-727b-4a66-8c13-54c22eff8dbf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_c767f1a8-540c-4a98-a565-7c406e09afeb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_18f218a1-727b-4a66-8c13-54c22eff8dbf" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_c767f1a8-540c-4a98-a565-7c406e09afeb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_HedgingDesignationAxis_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a" xlink:to="loc_us-gaap_HedgingDesignationDomain_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_a3cda456-f558-4249-8c40-aa9bc4188c55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_ed0519f6-de6e-4e0e-b5f0-4da8c7b4203a" xlink:to="loc_us-gaap_HedgingDesignationDomain_a3cda456-f558-4249-8c40-aa9bc4188c55" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_39eb3343-ce56-4ae5-8d90-77a4c167aac4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a3cda456-f558-4249-8c40-aa9bc4188c55" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_39eb3343-ce56-4ae5-8d90-77a4c167aac4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_21e0f606-5377-4ac4-8412-7e25180ab0b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_21e0f606-5377-4ac4-8412-7e25180ab0b8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_21e0f606-5377-4ac4-8412-7e25180ab0b8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_21e0f606-5377-4ac4-8412-7e25180ab0b8" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_21e0f606-5377-4ac4-8412-7e25180ab0b8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_756053ec-8085-4323-a3ad-dac1f16ad420" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_21e0f606-5377-4ac4-8412-7e25180ab0b8" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_756053ec-8085-4323-a3ad-dac1f16ad420" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_b9ffed9f-672f-4b95-8605-022542a1ec4b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_756053ec-8085-4323-a3ad-dac1f16ad420" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_b9ffed9f-672f-4b95-8605-022542a1ec4b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_ff217d88-7ae3-454c-9a83-769dbb4a8bf3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_756053ec-8085-4323-a3ad-dac1f16ad420" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_ff217d88-7ae3-454c-9a83-769dbb4a8bf3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_e44ba285-495b-4734-b3dc-6c48eb276e4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_756053ec-8085-4323-a3ad-dac1f16ad420" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_e44ba285-495b-4734-b3dc-6c48eb276e4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_2d9ddb9d-ba87-48fa-92e7-1ff218cd7129" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_66a101c8-e4c1-44e5-b1a3-8e3a552ac823" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:to="loc_us-gaap_MoneyMarketFundsMember_66a101c8-e4c1-44e5-b1a3-8e3a552ac823" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ExchangeTradedFundsMember_d942decd-ced8-4c8f-888b-18ea69d80a60" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ExchangeTradedFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:to="loc_us-gaap_ExchangeTradedFundsMember_d942decd-ced8-4c8f-888b-18ea69d80a60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:to="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_93dd2836-4217-4de5-8a2f-ad6d2a7cc503" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateBondSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_93dd2836-4217-4de5-8a2f-ad6d2a7cc503" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_a535bc5a-bd24-4523-a6b9-a7ea5bd7bcb1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_a535bc5a-bd24-4523-a6b9-a7ea5bd7bcb1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MortgageBackedSecuritiesMember_c132232a-0636-45ac-aca9-986205042fac" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MortgageBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:to="loc_us-gaap_MortgageBackedSecuritiesMember_c132232a-0636-45ac-aca9-986205042fac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetBackedSecuritiesMember_cb8f50f8-5456-4aba-bb4b-ee62eb711d28" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetBackedSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:to="loc_us-gaap_AssetBackedSecuritiesMember_cb8f50f8-5456-4aba-bb4b-ee62eb711d28" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDebtSecuritiesMember_5ad41458-d8e4-4ac5-803d-b03af45ce9a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtSecuritiesMember_6349c17a-8577-4c06-8bef-ae46d68b4948" xlink:to="loc_us-gaap_OtherDebtSecuritiesMember_5ad41458-d8e4-4ac5-803d-b03af45ce9a2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_50f694e6-454d-4070-a65f-9ff5df67e8d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:to="loc_us-gaap_CommonStockMember_50f694e6-454d-4070-a65f-9ff5df67e8d8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_0c100c69-dd69-4361-9e8d-84facf6e90b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_39777658-280a-40f9-8468-cbd519abb909" xlink:to="loc_us-gaap_InterestRateSwapMember_0c100c69-dd69-4361-9e8d-84facf6e90b5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_4bc7956a-befc-48a8-8e62-e4fcb18a964f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_4bc7956a-befc-48a8-8e62-e4fcb18a964f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_4bc7956a-befc-48a8-8e62-e4fcb18a964f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_4bc7956a-befc-48a8-8e62-e4fcb18a964f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_4bc7956a-befc-48a8-8e62-e4fcb18a964f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_1a9d91d4-c0b4-4501-99e2-3b0820492928" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_4bc7956a-befc-48a8-8e62-e4fcb18a964f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_1a9d91d4-c0b4-4501-99e2-3b0820492928" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_481c4d29-7625-49e4-8fef-92cb446d9939" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_1a9d91d4-c0b4-4501-99e2-3b0820492928" xlink:to="loc_us-gaap_ForeignExchangeContractMember_481c4d29-7625-49e4-8fef-92cb446d9939" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_4238cb0b-c7c0-4866-8775-4f2985161735" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_1a9d91d4-c0b4-4501-99e2-3b0820492928" xlink:to="loc_us-gaap_InterestRateSwapMember_4238cb0b-c7c0-4866-8775-4f2985161735" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ContingentConsiderationMember_12852cf9-8183-4141-bd9e-03f3ec243498" xlink:href="vtrs-20220630.xsd#vtrs_ContingentConsiderationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_1a9d91d4-c0b4-4501-99e2-3b0820492928" xlink:to="loc_vtrs_ContingentConsiderationMember_12852cf9-8183-4141-bd9e-03f3ec243498" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_c4296e76-17de-4a02-bdcb-3d50d6caac47" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8673634b-b211-414f-825e-6716ff0dfb51" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_c4296e76-17de-4a02-bdcb-3d50d6caac47" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_c4296e76-17de-4a02-bdcb-3d50d6caac47_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_c4296e76-17de-4a02-bdcb-3d50d6caac47" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_c4296e76-17de-4a02-bdcb-3d50d6caac47_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_7f82640d-18b9-4b8f-be32-23e89d4974af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_c4296e76-17de-4a02-bdcb-3d50d6caac47" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_7f82640d-18b9-4b8f-be32-23e89d4974af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_e3adb01b-dcf1-447f-a406-58d81c9747bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_7f82640d-18b9-4b8f-be32-23e89d4974af" xlink:to="loc_us-gaap_InterestRateSwapMember_e3adb01b-dcf1-447f-a406-58d81c9747bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_657fe230-8fd2-46fc-a39a-44ebe32c5c42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_7f82640d-18b9-4b8f-be32-23e89d4974af" xlink:to="loc_us-gaap_ForeignExchangeContractMember_657fe230-8fd2-46fc-a39a-44ebe32c5c42" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementRollforwardofContingentConsiderationDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#FinancialInstrumentsandRiskManagementRollforwardofContingentConsiderationDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementRollforwardofContingentConsiderationDetails" xlink:type="extended" id="i8e8ddbd39f6a4041abe2d4b47dd14725_FinancialInstrumentsandRiskManagementRollforwardofContingentConsiderationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_94bf0727-a346-4b38-9010-bb309bfa410b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:href="vtrs-20220630.xsd#vtrs_ScheduleofActivityinContingentConsiderationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_94bf0727-a346-4b38-9010-bb309bfa410b" xlink:to="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_18ab1a88-83f9-4102-8933-672712f4d891" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_18ab1a88-83f9-4102-8933-672712f4d891" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityPayments_12eb0d01-60db-4e45-bc75-f1d0709f0b0c" xlink:href="vtrs-20220630.xsd#vtrs_BusinessCombinationContingentConsiderationLiabilityPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:to="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityPayments_12eb0d01-60db-4e45-bc75-f1d0709f0b0c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BusinessCombinationContingentConsiderationArrangementsReclassifications_3ae2ffa6-a6cb-47cd-adc0-b7608f3b44b3" xlink:href="vtrs-20220630.xsd#vtrs_BusinessCombinationContingentConsiderationArrangementsReclassifications"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:to="loc_vtrs_BusinessCombinationContingentConsiderationArrangementsReclassifications_3ae2ffa6-a6cb-47cd-adc0-b7608f3b44b3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionExpense_036af858-8c99-4cea-8328-404fa8c2453b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:to="loc_us-gaap_AccretionExpense_036af858-8c99-4cea-8328-404fa8c2453b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityFairValueGainLoss_3b77d61a-7e09-471e-b2bb-34dca7f40c8c" xlink:href="vtrs-20220630.xsd#vtrs_BusinessCombinationContingentConsiderationLiabilityFairValueGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_vtrs_ScheduleofActivityinContingentConsiderationRollForward_245c232c-631e-49d2-9756-d58bb42c36af" xlink:to="loc_vtrs_BusinessCombinationContingentConsiderationLiabilityFairValueGainLoss_3b77d61a-7e09-471e-b2bb-34dca7f40c8c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_45037cc8-9512-47b2-a3bd-29cbc07d7a92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_61eb583c-eba6-4a81-8432-9bc22cbcbff0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_94bf0727-a346-4b38-9010-bb309bfa410b" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_61eb583c-eba6-4a81-8432-9bc22cbcbff0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_631300e6-f1ee-47f0-a78c-f9e6cfe67fed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_61eb583c-eba6-4a81-8432-9bc22cbcbff0" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_631300e6-f1ee-47f0-a78c-f9e6cfe67fed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_631300e6-f1ee-47f0-a78c-f9e6cfe67fed_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_631300e6-f1ee-47f0-a78c-f9e6cfe67fed" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_631300e6-f1ee-47f0-a78c-f9e6cfe67fed_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_e060ef31-ab11-412f-aec0-89ffb8916533" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_631300e6-f1ee-47f0-a78c-f9e6cfe67fed" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_e060ef31-ab11-412f-aec0-89ffb8916533" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_0e5a254a-7024-4e3c-ac39-82f023198e71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_e060ef31-ab11-412f-aec0-89ffb8916533" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_0e5a254a-7024-4e3c-ac39-82f023198e71" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_1f228508-c8e3-47dd-8df9-8fc41bc647b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_e060ef31-ab11-412f-aec0-89ffb8916533" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_1f228508-c8e3-47dd-8df9-8fc41bc647b4" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtReceivablesSecuritizationFacilityandCommercialPaperDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#DebtReceivablesSecuritizationFacilityandCommercialPaperDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/DebtReceivablesSecuritizationFacilityandCommercialPaperDetails" xlink:type="extended" id="i7956a3132b674325bf1cd17680d1a026_DebtReceivablesSecuritizationFacilityandCommercialPaperDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtLineItems_a8026149-236a-4457-87e8-9eaccb4911a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_d0821973-61ec-4be0-b012-0b2ff50b43f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtLineItems_a8026149-236a-4457-87e8-9eaccb4911a6" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_d0821973-61ec-4be0-b012-0b2ff50b43f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_b6a72191-f5ec-4c8c-9d7f-174c7a5e80d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermBorrowings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtLineItems_a8026149-236a-4457-87e8-9eaccb4911a6" xlink:to="loc_us-gaap_ShortTermBorrowings_b6a72191-f5ec-4c8c-9d7f-174c7a5e80d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShortTermDebtLineItems_a8026149-236a-4457-87e8-9eaccb4911a6" xlink:to="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_c15ecda2-3f9c-429f-b308-e03978643394" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:to="loc_us-gaap_DebtInstrumentAxis_c15ecda2-3f9c-429f-b308-e03978643394" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c15ecda2-3f9c-429f-b308-e03978643394_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_c15ecda2-3f9c-429f-b308-e03978643394" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c15ecda2-3f9c-429f-b308-e03978643394_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_49dc6665-bae2-4f97-b1af-d9fe33412c44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_c15ecda2-3f9c-429f-b308-e03978643394" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_49dc6665-bae2-4f97-b1af-d9fe33412c44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherCurrentPortionofLongtermDebtMember_e6bc921f-8634-4150-9997-d5a7bf4150b8" xlink:href="vtrs-20220630.xsd#vtrs_OtherCurrentPortionofLongtermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_49dc6665-bae2-4f97-b1af-d9fe33412c44" xlink:to="loc_vtrs_OtherCurrentPortionofLongtermDebtMember_e6bc921f-8634-4150-9997-d5a7bf4150b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_e1a869a0-2826-4103-8158-3749c66d0862" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_49dc6665-bae2-4f97-b1af-d9fe33412c44" xlink:to="loc_us-gaap_CommercialPaperMember_e1a869a0-2826-4103-8158-3749c66d0862" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ReceivablesFacilityMember_655a85a0-6c9a-4ad5-a446-60b7b579e943" xlink:href="vtrs-20220630.xsd#vtrs_ReceivablesFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_49dc6665-bae2-4f97-b1af-d9fe33412c44" xlink:to="loc_vtrs_ReceivablesFacilityMember_655a85a0-6c9a-4ad5-a446-60b7b579e943" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_8c3ad808-ef45-48f3-99d2-c638fb7f5e72" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:to="loc_srt_RangeAxis_8c3ad808-ef45-48f3-99d2-c638fb7f5e72" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8c3ad808-ef45-48f3-99d2-c638fb7f5e72_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_8c3ad808-ef45-48f3-99d2-c638fb7f5e72" xlink:to="loc_srt_RangeMember_8c3ad808-ef45-48f3-99d2-c638fb7f5e72_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2ebe9373-051f-4d86-9a2c-abd64c60b059" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_8c3ad808-ef45-48f3-99d2-c638fb7f5e72" xlink:to="loc_srt_RangeMember_2ebe9373-051f-4d86-9a2c-abd64c60b059" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_127ec1f7-3284-4320-b069-8556c4cd983d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2ebe9373-051f-4d86-9a2c-abd64c60b059" xlink:to="loc_srt_MinimumMember_127ec1f7-3284-4320-b069-8556c4cd983d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_cd027dcc-b395-4555-8522-4e6e237fc1da" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2ebe9373-051f-4d86-9a2c-abd64c60b059" xlink:to="loc_srt_MaximumMember_cd027dcc-b395-4555-8522-4e6e237fc1da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_0ac3ae73-b810-4ced-8a83-475855bebc9b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_0ac3ae73-b810-4ced-8a83-475855bebc9b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_0ac3ae73-b810-4ced-8a83-475855bebc9b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_0ac3ae73-b810-4ced-8a83-475855bebc9b" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_0ac3ae73-b810-4ced-8a83-475855bebc9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_ea1afd64-2a5f-491c-9924-20560580f891" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_0ac3ae73-b810-4ced-8a83-475855bebc9b" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_ea1afd64-2a5f-491c-9924-20560580f891" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_737ccc43-886d-458c-9c3b-a2f842f58f80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_ea1afd64-2a5f-491c-9924-20560580f891" xlink:to="loc_us-gaap_CommercialPaperMember_737ccc43-886d-458c-9c3b-a2f842f58f80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ReceivablesFacilityMember_011291d8-eca3-4a3e-baeb-d2834b405c88" xlink:href="vtrs-20220630.xsd#vtrs_ReceivablesFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_ea1afd64-2a5f-491c-9924-20560580f891" xlink:to="loc_vtrs_ReceivablesFacilityMember_011291d8-eca3-4a3e-baeb-d2834b405c88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_NoteSecuritizationFacilityMember_c3233830-1c75-4e9e-baf4-fefdba7e82e3" xlink:href="vtrs-20220630.xsd#vtrs_NoteSecuritizationFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_ea1afd64-2a5f-491c-9924-20560580f891" xlink:to="loc_vtrs_NoteSecuritizationFacilityMember_c3233830-1c75-4e9e-baf4-fefdba7e82e3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_9cee3089-a52f-4d1a-853b-caa67e4f90fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShortTermDebtTable_91eac005-cc2f-45c5-a3f6-a7b0237cbbc5" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_9cee3089-a52f-4d1a-853b-caa67e4f90fd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_9cee3089-a52f-4d1a-853b-caa67e4f90fd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9cee3089-a52f-4d1a-853b-caa67e4f90fd" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_9cee3089-a52f-4d1a-853b-caa67e4f90fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_9a9b5896-8ca8-4738-8ec6-4bfaa71eafcd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9cee3089-a52f-4d1a-853b-caa67e4f90fd" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_9a9b5896-8ca8-4738-8ec6-4bfaa71eafcd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_278b63cf-e9da-472a-81a5-87cc14e75961" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_9a9b5896-8ca8-4738-8ec6-4bfaa71eafcd" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_278b63cf-e9da-472a-81a5-87cc14e75961" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtSummaryofLongTermDebtDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#DebtSummaryofLongTermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/DebtSummaryofLongTermDebtDetails" xlink:type="extended" id="ifdf355d5e8214d79b8498f4c97c6f77f_DebtSummaryofLongTermDebtDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_f6eab123-71b9-401e-8a33-32ab51ff1e27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_f6eab123-71b9-401e-8a33-32ab51ff1e27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_a6922045-1fbb-473c-813e-8a6d51d22e11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_a6922045-1fbb-473c-813e-8a6d51d22e11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_fdb5f82c-4652-4d06-a666-d743c56aef23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_DebtCurrent_fdb5f82c-4652-4d06-a666-d743c56aef23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d0f32b8d-b3d6-4a85-8163-94f294572071" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d0f32b8d-b3d6-4a85-8163-94f294572071" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_f103c7ba-657a-45ad-95d2-68adcfe8e694" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_LongTermDebt_f103c7ba-657a-45ad-95d2-68adcfe8e694" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_bbf77f7a-51b1-4016-8668-3ad4db279a6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_LineOfCredit_bbf77f7a-51b1-4016-8668-3ad4db279a6e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities_8ad37940-0ff8-4ec3-862f-bbc93b9e8da8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_ProceedsFromSaleOfSecuritiesOperatingActivities_8ad37940-0ff8-4ec3-862f-bbc93b9e8da8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_86de80ea-abf9-471e-ba24-635595c0aaa2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_dcfac15d-f966-4219-a894-dd32c7776e5b" xlink:to="loc_us-gaap_DebtInstrumentTable_86de80ea-abf9-471e-ba24-635595c0aaa2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeAxis_1fd3e221-6e02-4864-952e-8ea4e9f906c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_86de80ea-abf9-471e-ba24-635595c0aaa2" xlink:to="loc_us-gaap_ShortTermDebtTypeAxis_1fd3e221-6e02-4864-952e-8ea4e9f906c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_1fd3e221-6e02-4864-952e-8ea4e9f906c0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_1fd3e221-6e02-4864-952e-8ea4e9f906c0" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_1fd3e221-6e02-4864-952e-8ea4e9f906c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermDebtTypeDomain_ea499334-9cd2-4211-96db-b46759a1b416" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShortTermDebtTypeAxis_1fd3e221-6e02-4864-952e-8ea4e9f906c0" xlink:to="loc_us-gaap_ShortTermDebtTypeDomain_ea499334-9cd2-4211-96db-b46759a1b416" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_d49cf8ec-3a3e-4047-866d-b1ddbf81f0b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermDebtTypeDomain_ea499334-9cd2-4211-96db-b46759a1b416" xlink:to="loc_us-gaap_SeniorNotesMember_d49cf8ec-3a3e-4047-866d-b1ddbf81f0b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_e075fd57-fc7f-49a8-8e03-80134befe510" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_86de80ea-abf9-471e-ba24-635595c0aaa2" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_e075fd57-fc7f-49a8-8e03-80134befe510" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_e075fd57-fc7f-49a8-8e03-80134befe510_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_e075fd57-fc7f-49a8-8e03-80134befe510" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_e075fd57-fc7f-49a8-8e03-80134befe510_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_e075fd57-fc7f-49a8-8e03-80134befe510" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_3cc6853b-d017-40db-8450-ff6ca070e75b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:to="loc_us-gaap_SeniorNotesMember_3cc6853b-d017-40db-8450-ff6ca070e75b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherLongTermDebtMember_fce6abe3-1c1d-4e29-bf22-e2e7e0c214c3" xlink:href="vtrs-20220630.xsd#vtrs_OtherLongTermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:to="loc_vtrs_OtherLongTermDebtMember_fce6abe3-1c1d-4e29-bf22-e2e7e0c214c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_CurrentPortionofLongTermDebtMember_c2c02483-83c5-40d8-8cdc-a15ee25d1b7f" xlink:href="vtrs-20220630.xsd#vtrs_CurrentPortionofLongTermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:to="loc_vtrs_CurrentPortionofLongTermDebtMember_c2c02483-83c5-40d8-8cdc-a15ee25d1b7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_9fec2481-4b0d-4170-9f61-b522a07514fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_6fdae410-e2a7-4e89-950d-d0cac618a1ff" xlink:to="loc_us-gaap_LineOfCreditMember_9fec2481-4b0d-4170-9f61-b522a07514fa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_b236a320-53b6-48ed-9598-518d03a9cf58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_86de80ea-abf9-471e-ba24-635595c0aaa2" xlink:to="loc_us-gaap_DebtInstrumentAxis_b236a320-53b6-48ed-9598-518d03a9cf58" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_b236a320-53b6-48ed-9598-518d03a9cf58_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_b236a320-53b6-48ed-9598-518d03a9cf58" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_b236a320-53b6-48ed-9598-518d03a9cf58_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_b236a320-53b6-48ed-9598-518d03a9cf58" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherCurrentPortionofLongtermDebtMember_3827cc88-b963-46c8-b18b-6a36a9a538f8" xlink:href="vtrs-20220630.xsd#vtrs_OtherCurrentPortionofLongtermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_OtherCurrentPortionofLongtermDebtMember_3827cc88-b963-46c8-b18b-6a36a9a538f8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2020EuroSeniorNotesMember_98ea4e90-1ec7-4745-9d1e-259291dba471" xlink:href="vtrs-20220630.xsd#vtrs_A2020EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2020EuroSeniorNotesMember_98ea4e90-1ec7-4745-9d1e-259291dba471" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwenty3.75PercentMember_0baf2070-0b71-419e-8fc4-0e33cba484f8" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwenty3.75PercentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwenty3.75PercentMember_0baf2070-0b71-419e-8fc4-0e33cba484f8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember_efe9b5c4-6d09-46d3-af4b-416dee1634ba" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwentyThree3.125PercentMember_efe9b5c4-6d09-46d3-af4b-416dee1634ba" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwentyThree4.2PercentMember_372faddc-d61e-4cd9-b8dc-5a4daaca650d" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwentyThree4.2PercentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwentyThree4.2PercentMember_372faddc-d61e-4cd9-b8dc-5a4daaca650d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2024EuroSeniorNotesMember_df5c805d-0f90-4416-b49d-fe11f2d7c18a" xlink:href="vtrs-20220630.xsd#vtrs_A2024EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2024EuroSeniorNotesMember_df5c805d-0f90-4416-b49d-fe11f2d7c18a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2025EuroSeniorNotesMember_42599554-0042-490f-9706-b9d22361f469" xlink:href="vtrs-20220630.xsd#vtrs_A2025EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2025EuroSeniorNotesMember_42599554-0042-490f-9706-b9d22361f469" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwentySix3.95PrecentMember_21545bc7-5505-4835-b37a-893086f69f4f" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwentySix3.95PrecentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwentySix3.95PrecentMember_21545bc7-5505-4835-b37a-893086f69f4f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2028EuroSeniorNotesMember_22d0b684-e99e-485b-a2f9-bc95fd8c2339" xlink:href="vtrs-20220630.xsd#vtrs_A2028EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2028EuroSeniorNotesMember_22d0b684-e99e-485b-a2f9-bc95fd8c2339" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandTwentyEightMember_976198a2-3bcc-4638-9523-3f306b51cc9f" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandTwentyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandTwentyEightMember_976198a2-3bcc-4638-9523-3f306b51cc9f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2028SeniorNotesMember_f0fe41b4-9168-4e75-9998-5bd802308072" xlink:href="vtrs-20220630.xsd#vtrs_A2028SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2028SeniorNotesMember_f0fe41b4-9168-4e75-9998-5bd802308072" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandFortyThreeMember_9d02a1a4-97de-42c7-bb85-181cd15d4a4e" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandFortyThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandFortyThreeMember_9d02a1a4-97de-42c7-bb85-181cd15d4a4e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandFortySix5.25PrecentMember_64c8e162-e194-4fdf-91fc-e1e2e50418e5" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandFortySix5.25PrecentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandFortySix5.25PrecentMember_64c8e162-e194-4fdf-91fc-e1e2e50418e5" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SeniorNotesTwoThousandFortyEightMember_20052df9-2f94-4b48-b06c-383dabb55a70" xlink:href="vtrs-20220630.xsd#vtrs_SeniorNotesTwoThousandFortyEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_SeniorNotesTwoThousandFortyEightMember_20052df9-2f94-4b48-b06c-383dabb55a70" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherLongTermDebtMember_697daf78-96a3-40ec-93e8-72a0ad02a306" xlink:href="vtrs-20220630.xsd#vtrs_OtherLongTermDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_OtherLongTermDebtMember_697daf78-96a3-40ec-93e8-72a0ad02a306" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2048SeniorNotesMember_11fa5c06-73cf-4568-83a1-ad6e3c81772a" xlink:href="vtrs-20220630.xsd#vtrs_A2048SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2048SeniorNotesMember_11fa5c06-73cf-4568-83a1-ad6e3c81772a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2022EuroSeniorNotesMember_1c1c9b5e-7b43-4f0c-88ca-8bba96b06862" xlink:href="vtrs-20220630.xsd#vtrs_A2022EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2022EuroSeniorNotesMember_1c1c9b5e-7b43-4f0c-88ca-8bba96b06862" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2024EuroSeniorNotes1023Member_3643d6fc-793e-43ab-bbf7-4275c5866c6c" xlink:href="vtrs-20220630.xsd#vtrs_A2024EuroSeniorNotes1023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2024EuroSeniorNotes1023Member_3643d6fc-793e-43ab-bbf7-4275c5866c6c" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2025SeniorNotesMember_bc18a8b0-3cf0-474e-b64a-c28246901d1b" xlink:href="vtrs-20220630.xsd#vtrs_A2025SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2025SeniorNotesMember_bc18a8b0-3cf0-474e-b64a-c28246901d1b" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2027EuroSeniorNotesMember_9789e1d2-2adb-425b-a778-6e8b827d57c9" xlink:href="vtrs-20220630.xsd#vtrs_A2027EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2027EuroSeniorNotesMember_9789e1d2-2adb-425b-a778-6e8b827d57c9" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2027SeniorNotesMember_92ac39c6-2a7f-4e5f-ad97-44828d89aedd" xlink:href="vtrs-20220630.xsd#vtrs_A2027SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2027SeniorNotesMember_92ac39c6-2a7f-4e5f-ad97-44828d89aedd" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2030SeniorNotesMember_34b3b7cd-a3ee-45ed-8b39-04b64b30c3d1" xlink:href="vtrs-20220630.xsd#vtrs_A2030SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2030SeniorNotesMember_34b3b7cd-a3ee-45ed-8b39-04b64b30c3d1" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2032EuroSeniorNotesMember_ca73aedc-45e7-4af1-876f-0e6dcc17a824" xlink:href="vtrs-20220630.xsd#vtrs_A2032EuroSeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2032EuroSeniorNotesMember_ca73aedc-45e7-4af1-876f-0e6dcc17a824" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2040SeniorNotesMember_b8988a91-16d5-4047-b147-b97836e30d53" xlink:href="vtrs-20220630.xsd#vtrs_A2040SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2040SeniorNotesMember_b8988a91-16d5-4047-b147-b97836e30d53" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2050SeniorNotesMember_2f3be9ff-89ed-40ff-b814-81f53ca8fe03" xlink:href="vtrs-20220630.xsd#vtrs_A2050SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_A2050SeniorNotesMember_2f3be9ff-89ed-40ff-b814-81f53ca8fe03" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_RevolvingFacilityMember_fa1e5491-4472-4afc-95d4-eca1a14f39d4" xlink:href="vtrs-20220630.xsd#vtrs_RevolvingFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_e58b7e3a-8f6f-4e04-a962-58a2b600bf8e" xlink:to="loc_vtrs_RevolvingFacilityMember_fa1e5491-4472-4afc-95d4-eca1a14f39d4" xlink:type="arc" order="25"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/Debt2016and2018RevolvingFacilityand2016TermFacilityNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#Debt2016and2018RevolvingFacilityand2016TermFacilityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/Debt2016and2018RevolvingFacilityand2016TermFacilityNarrativeDetails" xlink:type="extended" id="iffcf868924e340efa77b9dfaa2a3b649_Debt2016and2018RevolvingFacilityand2016TermFacilityNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_17827b4f-a435-4e59-a1c9-2d9963823233" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_490a7309-ea90-4c11-b3ad-c5a012599e3f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_17827b4f-a435-4e59-a1c9-2d9963823233" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_490a7309-ea90-4c11-b3ad-c5a012599e3f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtCurrent_b0663b26-651f-4078-a544-5c4b7937ceab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_17827b4f-a435-4e59-a1c9-2d9963823233" xlink:to="loc_us-gaap_DebtCurrent_b0663b26-651f-4078-a544-5c4b7937ceab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_76077f27-1b22-47dd-9825-94cfd5ced602" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_17827b4f-a435-4e59-a1c9-2d9963823233" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_76077f27-1b22-47dd-9825-94cfd5ced602" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_95a4d567-2c88-4a11-853a-eeb7d6111a67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_17827b4f-a435-4e59-a1c9-2d9963823233" xlink:to="loc_us-gaap_DebtInstrumentTable_95a4d567-2c88-4a11-853a-eeb7d6111a67" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_95a4d567-2c88-4a11-853a-eeb7d6111a67" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_626670f5-075b-417a-83eb-5740491e1b94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b5dd50bc-6f01-4a98-9e8e-6110fc0d6fa8" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_626670f5-075b-417a-83eb-5740491e1b94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_22590326-1ec5-4e89-9553-295ce82c39c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_626670f5-075b-417a-83eb-5740491e1b94" xlink:to="loc_us-gaap_LineOfCreditMember_22590326-1ec5-4e89-9553-295ce82c39c2" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtFairValueNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#DebtFairValueNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/DebtFairValueNarrativeDetails" xlink:type="extended" id="idaf66e3654a54521871142291b2000e8_DebtFairValueNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_c56aee00-b705-4ffa-8338-4d530100356f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_292b27f5-3f56-433a-bfc0-f7dbbb7b10a3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_c56aee00-b705-4ffa-8338-4d530100356f" xlink:to="loc_us-gaap_DebtInstrumentFairValue_292b27f5-3f56-433a-bfc0-f7dbbb7b10a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_42412458-7e82-4c14-ac9e-622e987107ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_c56aee00-b705-4ffa-8338-4d530100356f" xlink:to="loc_us-gaap_DebtInstrumentTable_42412458-7e82-4c14-ac9e-622e987107ef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_d3f795ed-a6eb-4022-8118-7e7cb20be740" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_42412458-7e82-4c14-ac9e-622e987107ef" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_d3f795ed-a6eb-4022-8118-7e7cb20be740" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d3f795ed-a6eb-4022-8118-7e7cb20be740_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d3f795ed-a6eb-4022-8118-7e7cb20be740" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d3f795ed-a6eb-4022-8118-7e7cb20be740_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f19f26f5-1438-4117-9620-bb881872d0d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d3f795ed-a6eb-4022-8118-7e7cb20be740" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f19f26f5-1438-4117-9620-bb881872d0d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_76b1bf95-3f0d-4709-8931-97e7093bd868" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f19f26f5-1438-4117-9620-bb881872d0d0" xlink:to="loc_us-gaap_SeniorNotesMember_76b1bf95-3f0d-4709-8931-97e7093bd868" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ComprehensiveEarningsAccumulatedOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#ComprehensiveEarningsAccumulatedOtherComprehensiveIncomeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/ComprehensiveEarningsAccumulatedOtherComprehensiveIncomeDetails" xlink:type="extended" id="i4f9885a509d842758b27e12758aaaeeb_ComprehensiveEarningsAccumulatedOtherComprehensiveIncomeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_f440be04-da9f-4716-82b5-c0fe8fb6297b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_f440be04-da9f-4716-82b5-c0fe8fb6297b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_d8bf4870-0937-4e09-bde9-0f89f60b2237" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_d8bf4870-0937-4e09-bde9-0f89f60b2237" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax_58f62ba9-a5a8-472a-8d9b-228fc396d95e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax_58f62ba9-a5a8-472a-8d9b-228fc396d95e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx_dd5944f5-1aef-49be-bb76-7b03427f9aa7" xlink:href="vtrs-20220630.xsd#vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx_dd5944f5-1aef-49be-bb76-7b03427f9aa7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax_d9d88fcc-32f2-48c5-9bc9-c316ca3e62c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax_d9d88fcc-32f2-48c5-9bc9-c316ca3e62c8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_822057c8-a0f6-4501-b1cb-d4522969fc94" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_822057c8-a0f6-4501-b1cb-d4522969fc94" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_11f32a7b-df27-4580-8ffd-e6e9dcfb5f34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e8247e2d-f04c-49fa-b579-893937458015" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_11f32a7b-df27-4580-8ffd-e6e9dcfb5f34" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_11f32a7b-df27-4580-8ffd-e6e9dcfb5f34" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3" xlink:to="loc_us-gaap_HedgingRelationshipDomain_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_54f842a2-2524-40ee-9d0a-1255b02dd13b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_2be71d1e-d0e5-4a04-8fcf-b7c11e8c1ff3" xlink:to="loc_us-gaap_HedgingRelationshipDomain_54f842a2-2524-40ee-9d0a-1255b02dd13b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_d72684b7-9e16-4821-b554-1ccd5e2105a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_54f842a2-2524-40ee-9d0a-1255b02dd13b" xlink:to="loc_us-gaap_CashFlowHedgingMember_d72684b7-9e16-4821-b554-1ccd5e2105a6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_74ccdaee-4500-4069-afef-60db29722207" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_54f842a2-2524-40ee-9d0a-1255b02dd13b" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_74ccdaee-4500-4069-afef-60db29722207" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_aa562eb8-87ad-49cf-b706-365ce11a1b90" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_11f32a7b-df27-4580-8ffd-e6e9dcfb5f34" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_aa562eb8-87ad-49cf-b706-365ce11a1b90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_aa562eb8-87ad-49cf-b706-365ce11a1b90_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_aa562eb8-87ad-49cf-b706-365ce11a1b90" xlink:to="loc_us-gaap_EquityComponentDomain_aa562eb8-87ad-49cf-b706-365ce11a1b90_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_91d255c9-e248-431a-bec6-2ea81e4fbfef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_aa562eb8-87ad-49cf-b706-365ce11a1b90" xlink:to="loc_us-gaap_EquityComponentDomain_91d255c9-e248-431a-bec6-2ea81e4fbfef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_e8ca2d99-cf39-48ea-b102-55c6c46c5de8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_91d255c9-e248-431a-bec6-2ea81e4fbfef" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_e8ca2d99-cf39-48ea-b102-55c6c46c5de8" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ComprehensiveEarningsComponentsofOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#ComprehensiveEarningsComponentsofOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/ComprehensiveEarningsComponentsofOtherComprehensiveLossDetails" xlink:type="extended" id="i341305034d3c4f79a6754f4a171ed846_ComprehensiveEarningsComponentsofOtherComprehensiveLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossCumulativeChangesInNetGainLossFromCashFlowHedgesEffectNetOfTax_8bb96fc8-55d0-4fa8-ad83-c5862331aa4e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossCumulativeChangesInNetGainLossFromCashFlowHedgesEffectNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossCumulativeChangesInNetGainLossFromCashFlowHedgesEffectNetOfTax_8bb96fc8-55d0-4fa8-ad83-c5862331aa4e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx_c87a9f99-01db-44e7-83d1-267b270736fc" xlink:href="vtrs-20220630.xsd#vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_vtrs_AccumulateOtherComprehensiveIncomeLossCumulativeChangesinNetGainLossfromNetInvestmentHedgesEffectNetofTaxx_c87a9f99-01db-44e7-83d1-267b270736fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4d6c9fbc-6fc3-4f08-822a-fadde3648e2d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_4d6c9fbc-6fc3-4f08-822a-fadde3648e2d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_14f84b16-84b6-4917-91d5-6925de3ca7fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_14f84b16-84b6-4917-91d5-6925de3ca7fd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax_192db0bd-5070-4320-87d2-07288fcef5bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossForeignCurrencyTranslationAdjustmentNetOfTax_192db0bd-5070-4320-87d2-07288fcef5bf" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d09cf5d7-9541-4e65-a37d-544f3ea7588a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_d09cf5d7-9541-4e65-a37d-544f3ea7588a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_0c79356b-701d-4c21-b73e-3780db729b8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_0c79356b-701d-4c21-b73e-3780db729b8f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent_252d9c0c-47f0-4681-898d-252bfa6c724a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseAfterAdjustmentsBeforeTaxParent_252d9c0c-47f0-4681-898d-252bfa6c724a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_e04228cb-3974-4898-9bdc-28d01dac7f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentBeforeTaxPortionAttributableToParent_e04228cb-3974-4898-9bdc-28d01dac7f6f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_15231f8d-42d8-4e80-8fea-4aa8be2a89c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_15231f8d-42d8-4e80-8fea-4aa8be2a89c8" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_4e547732-fcfa-4932-915d-d90c60772ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_InterestExpense_4e547732-fcfa-4932-915d-d90c60772ed0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_c606e7a4-20c7-485f-8f27-8f7e3829cb93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_c606e7a4-20c7-485f-8f27-8f7e3829cb93" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_63cfa12f-8b49-4a9e-a323-849185b0de03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_63cfa12f-8b49-4a9e-a323-849185b0de03" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_1fc4107b-7fdd-47fe-902c-50b27e776bbb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_1fc4107b-7fdd-47fe-902c-50b27e776bbb" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_9641bbf4-d02c-45db-9db0-c19418a04ac1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_9641bbf4-d02c-45db-9db0-c19418a04ac1" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_84758f4d-7204-4c2b-9a20-94ee8db3c1d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_84758f4d-7204-4c2b-9a20-94ee8db3c1d2" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_804c4eef-28be-457e-819b-a468789ff478" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_804c4eef-28be-457e-819b-a468789ff478" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax_4f414440-640b-4d61-8bc1-8eb71a9e9611" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AociLossCashFlowHedgeCumulativeGainLossAfterTax_4f414440-640b-4d61-8bc1-8eb71a9e9611" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_569fea86-650e-49e0-a55b-7f6790d543dc" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_6f7af48f-0f8a-476f-9048-fb6264198eda" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_6f7af48f-0f8a-476f-9048-fb6264198eda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_6f7af48f-0f8a-476f-9048-fb6264198eda_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_6f7af48f-0f8a-476f-9048-fb6264198eda" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_6f7af48f-0f8a-476f-9048-fb6264198eda_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_4520f032-6983-44e4-868e-51f746e06fae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_6f7af48f-0f8a-476f-9048-fb6264198eda" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_4520f032-6983-44e4-868e-51f746e06fae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember_5eda28e3-a69a-4e9c-b7c2-0744462cf1c9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_4520f032-6983-44e4-868e-51f746e06fae" xlink:to="loc_us-gaap_OtherPensionPlansPostretirementOrSupplementalPlansDefinedBenefitMember_5eda28e3-a69a-4e9c-b7c2-0744462cf1c9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b3025578-1131-4784-b8e2-a5c3301ad9fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b3025578-1131-4784-b8e2-a5c3301ad9fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b3025578-1131-4784-b8e2-a5c3301ad9fb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b3025578-1131-4784-b8e2-a5c3301ad9fb" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b3025578-1131-4784-b8e2-a5c3301ad9fb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_0b3ae898-6e78-4915-91de-20b3ad3a4aa4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b3025578-1131-4784-b8e2-a5c3301ad9fb" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_0b3ae898-6e78-4915-91de-20b3ad3a4aa4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_2a59c0ab-fe8a-4dae-8121-ad278d9708e3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0b3ae898-6e78-4915-91de-20b3ad3a4aa4" xlink:to="loc_us-gaap_ForeignExchangeContractMember_2a59c0ab-fe8a-4dae-8121-ad278d9708e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_ad69ef13-fc50-4bf8-bd7e-46ac0f25e4a6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_0b3ae898-6e78-4915-91de-20b3ad3a4aa4" xlink:to="loc_us-gaap_InterestRateSwapMember_ad69ef13-fc50-4bf8-bd7e-46ac0f25e4a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_473f3c1c-987a-42c6-a4bc-a51f0e17266d" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_srt_ConsolidatedEntitiesAxis_473f3c1c-987a-42c6-a4bc-a51f0e17266d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_473f3c1c-987a-42c6-a4bc-a51f0e17266d_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_473f3c1c-987a-42c6-a4bc-a51f0e17266d" xlink:to="loc_srt_ConsolidatedEntitiesDomain_473f3c1c-987a-42c6-a4bc-a51f0e17266d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_f8f3bd8e-de7c-41c0-a70a-41bd9d4f4376" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_473f3c1c-987a-42c6-a4bc-a51f0e17266d" xlink:to="loc_srt_ConsolidatedEntitiesDomain_f8f3bd8e-de7c-41c0-a70a-41bd9d4f4376" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ParentCompanyMember_fa7534df-018c-418f-91f1-b9141c3d0d5c" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ParentCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_f8f3bd8e-de7c-41c0-a70a-41bd9d4f4376" xlink:to="loc_srt_ParentCompanyMember_fa7534df-018c-418f-91f1-b9141c3d0d5c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_ae05f9ef-575f-47fa-8cd4-02520fcc39b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_ae05f9ef-575f-47fa-8cd4-02520fcc39b8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_ae05f9ef-575f-47fa-8cd4-02520fcc39b8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_ae05f9ef-575f-47fa-8cd4-02520fcc39b8" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_ae05f9ef-575f-47fa-8cd4-02520fcc39b8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_7c826865-3a5c-424f-b541-29ed65771535" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeAxis_ae05f9ef-575f-47fa-8cd4-02520fcc39b8" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_7c826865-3a5c-424f-b541-29ed65771535" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_3e360940-c410-4c73-b7e9-90bf88fc26c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeDomain_7c826865-3a5c-424f-b541-29ed65771535" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeMember_3e360940-c410-4c73-b7e9-90bf88fc26c1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_40458770-d748-42bc-8b60-51988f5be32b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_40458770-d748-42bc-8b60-51988f5be32b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_40458770-d748-42bc-8b60-51988f5be32b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_40458770-d748-42bc-8b60-51988f5be32b" xlink:to="loc_us-gaap_EquityComponentDomain_40458770-d748-42bc-8b60-51988f5be32b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_40458770-d748-42bc-8b60-51988f5be32b" xlink:to="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_dc5272e1-ed44-4eca-908a-c1a784d96464" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_dc5272e1-ed44-4eca-908a-c1a784d96464" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_5a37e117-7ac9-41ec-b029-416a49e75ace" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:to="loc_us-gaap_AccumulatedNetGainLossFromDesignatedOrQualifyingCashFlowHedgesMember_5a37e117-7ac9-41ec-b029-416a49e75ace" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_2d6fbafa-60a6-4ee4-a920-77885f34097a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_2d6fbafa-60a6-4ee4-a920-77885f34097a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_af0c5256-ad6b-4e05-82a5-ec2be93c9662" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_af0c5256-ad6b-4e05-82a5-ec2be93c9662" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_57f13d06-475f-433a-842f-08d84c60be97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_7a5c3c0c-5aee-45b7-b131-cdec3e709f54" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_57f13d06-475f-433a-842f-08d84c60be97" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_17b84ded-9b22-4532-9fc8-accc82602bbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_a4b8e80b-da59-462b-911d-e31afe811173" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_17b84ded-9b22-4532-9fc8-accc82602bbd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_17b84ded-9b22-4532-9fc8-accc82602bbd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_17b84ded-9b22-4532-9fc8-accc82602bbd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_17b84ded-9b22-4532-9fc8-accc82602bbd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_5109936e-4a79-4bfa-b312-363fda22cfa9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_17b84ded-9b22-4532-9fc8-accc82602bbd" xlink:to="loc_us-gaap_HedgingRelationshipDomain_5109936e-4a79-4bfa-b312-363fda22cfa9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_e763cdd2-f568-497c-a470-4751162c5609" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_5109936e-4a79-4bfa-b312-363fda22cfa9" xlink:to="loc_us-gaap_CashFlowHedgingMember_e763cdd2-f568-497c-a470-4751162c5609" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_aa9d407e-27fd-4a83-b5cc-e38b150a62d6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_5109936e-4a79-4bfa-b312-363fda22cfa9" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_aa9d407e-27fd-4a83-b5cc-e38b150a62d6" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/SegmentInformationReconciliationOfSegmentInformationToTotalConsolidatedInformationDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#SegmentInformationReconciliationOfSegmentInformationToTotalConsolidatedInformationDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/SegmentInformationReconciliationOfSegmentInformationToTotalConsolidatedInformationDetails" xlink:type="extended" id="ia6ca0358c8884f729347523144ee3ffa_SegmentInformationReconciliationOfSegmentInformationToTotalConsolidatedInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4573e4d0-3197-4350-a387-f531b6fc01ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4573e4d0-3197-4350-a387-f531b6fc01ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_9e113d94-3a9b-4743-b8c1-48cbf7fb88f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_Revenues_9e113d94-3a9b-4743-b8c1-48cbf7fb88f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_7cadce8a-3127-4dc3-ab5e-9a6af3fde902" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_7cadce8a-3127-4dc3-ab5e-9a6af3fde902" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_2f71e4a3-a30a-4943-af85-8471167d79d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_2f71e4a3-a30a-4943-af85-8471167d79d9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_08c3aff5-e05c-4954-8877-5ea3d77c2ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_08c3aff5-e05c-4954-8877-5ea3d77c2ef5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Corporatecosts_9501976f-f7d6-44b6-9a12-0be94f9a3080" xlink:href="vtrs-20220630.xsd#vtrs_Corporatecosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_vtrs_Corporatecosts_9501976f-f7d6-44b6-9a12-0be94f9a3080" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_ac3b974d-1f5f-4599-913b-81821fd162ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_ac3b974d-1f5f-4599-913b-81821fd162ed" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_df43cd54-8666-4ade-90e3-50d0e149ff1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_OperatingIncomeLoss_df43cd54-8666-4ade-90e3-50d0e149ff1b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherOneTimeNonoperatingExpense_b2799727-4a91-4be5-95f7-249e2e1bf7ae" xlink:href="vtrs-20220630.xsd#vtrs_OtherOneTimeNonoperatingExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_vtrs_OtherOneTimeNonoperatingExpense_b2799727-4a91-4be5-95f7-249e2e1bf7ae" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_23f4b456-d9ad-487c-b5b2-8eb6588ae08a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b846975a-051d-4a91-8a81-0eacbe12c1a1" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_23f4b456-d9ad-487c-b5b2-8eb6588ae08a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_f7260d2d-28c0-4217-bbb8-b43278493afd" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_23f4b456-d9ad-487c-b5b2-8eb6588ae08a" xlink:to="loc_srt_ProductOrServiceAxis_f7260d2d-28c0-4217-bbb8-b43278493afd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_f7260d2d-28c0-4217-bbb8-b43278493afd_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_f7260d2d-28c0-4217-bbb8-b43278493afd" xlink:to="loc_srt_ProductsAndServicesDomain_f7260d2d-28c0-4217-bbb8-b43278493afd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_b9f1d29d-82fa-438b-8901-b6a87f02f765" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_f7260d2d-28c0-4217-bbb8-b43278493afd" xlink:to="loc_srt_ProductsAndServicesDomain_b9f1d29d-82fa-438b-8901-b6a87f02f765" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_511d6807-2bf7-4bee-bfdc-7c10a82c922d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProductAndServiceOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b9f1d29d-82fa-438b-8901-b6a87f02f765" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_511d6807-2bf7-4bee-bfdc-7c10a82c922d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_783b01f0-7998-477d-b2fc-f1511eee4d9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_23f4b456-d9ad-487c-b5b2-8eb6588ae08a" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_783b01f0-7998-477d-b2fc-f1511eee4d9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_783b01f0-7998-477d-b2fc-f1511eee4d9c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_783b01f0-7998-477d-b2fc-f1511eee4d9c" xlink:to="loc_us-gaap_SegmentDomain_783b01f0-7998-477d-b2fc-f1511eee4d9c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_783b01f0-7998-477d-b2fc-f1511eee4d9c" xlink:to="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DevelopedMarketsSegmentMember_059c93ef-2e74-4f42-b2d3-3f852ea735f5" xlink:href="vtrs-20220630.xsd#vtrs_DevelopedMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:to="loc_vtrs_DevelopedMarketsSegmentMember_059c93ef-2e74-4f42-b2d3-3f852ea735f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GreaterChinaSegmentMember_0bb75714-bf38-4a79-8364-377b0d7db52b" xlink:href="vtrs-20220630.xsd#vtrs_GreaterChinaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:to="loc_vtrs_GreaterChinaSegmentMember_0bb75714-bf38-4a79-8364-377b0d7db52b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_13b478ba-aa92-4b53-b206-34b816aa2fb6" xlink:href="vtrs-20220630.xsd#vtrs_JapanAustraliaAndNewZealandSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:to="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_13b478ba-aa92-4b53-b206-34b816aa2fb6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EmergingMarketsSegmentMember_bfb5ed84-9ddd-4225-abf9-c4e78b737da2" xlink:href="vtrs-20220630.xsd#vtrs_EmergingMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_4e93486a-b70a-4294-bcdb-272122609848" xlink:to="loc_vtrs_EmergingMarketsSegmentMember_bfb5ed84-9ddd-4225-abf9-c4e78b737da2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_750a4dc1-106c-4905-9605-a4091645928b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_23f4b456-d9ad-487c-b5b2-8eb6588ae08a" xlink:to="loc_srt_ConsolidationItemsAxis_750a4dc1-106c-4905-9605-a4091645928b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_750a4dc1-106c-4905-9605-a4091645928b_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_750a4dc1-106c-4905-9605-a4091645928b" xlink:to="loc_srt_ConsolidationItemsDomain_750a4dc1-106c-4905-9605-a4091645928b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_742d4aa4-43da-46af-91a5-5bfefe265d04" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_750a4dc1-106c-4905-9605-a4091645928b" xlink:to="loc_srt_ConsolidationItemsDomain_742d4aa4-43da-46af-91a5-5bfefe265d04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_04358f27-98b5-4591-b3e3-45e126a69ff3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_742d4aa4-43da-46af-91a5-5bfefe265d04" xlink:to="loc_us-gaap_OperatingSegmentsMember_04358f27-98b5-4591-b3e3-45e126a69ff3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialReconcilingItemsMember_b3849552-d0f7-40c1-adeb-96e32435f9bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaterialReconcilingItemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_742d4aa4-43da-46af-91a5-5bfefe265d04" xlink:to="loc_us-gaap_MaterialReconcilingItemsMember_b3849552-d0f7-40c1-adeb-96e32435f9bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_5e50b4c0-2fd6-4e2b-914e-1e8ef71fedc7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_742d4aa4-43da-46af-91a5-5bfefe265d04" xlink:to="loc_us-gaap_CorporateNonSegmentMember_5e50b4c0-2fd6-4e2b-914e-1e8ef71fedc7" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RestructuringRestructuringChargesDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#RestructuringRestructuringChargesDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/RestructuringRestructuringChargesDetails" xlink:type="extended" id="i83b4ac17257c406781d79267391cf5f4_RestructuringRestructuringChargesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_944ac60c-8834-4850-b502-9f8cba4f60ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveSettledWithoutCash2_58117a53-a115-44c2-a6db-ef01fdf00d33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserveSettledWithoutCash2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_944ac60c-8834-4850-b502-9f8cba4f60ec" xlink:to="loc_us-gaap_RestructuringReserveSettledWithoutCash2_58117a53-a115-44c2-a6db-ef01fdf00d33" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCostRemaining1_7713d897-4213-47a0-ae8f-d139b4ec6e89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringAndRelatedCostExpectedCostRemaining1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_944ac60c-8834-4850-b502-9f8cba4f60ec" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCostRemaining1_7713d897-4213-47a0-ae8f-d139b4ec6e89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_944ac60c-8834-4850-b502-9f8cba4f60ec" xlink:to="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_54a9883b-e75a-43ea-ae11-4b52af76b8fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:to="loc_us-gaap_RestructuringReserve_54a9883b-e75a-43ea-ae11-4b52af76b8fc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_735a7d93-0e26-4d8f-a962-f2eb2f20fd23" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:to="loc_us-gaap_RestructuringCharges_735a7d93-0e26-4d8f-a962-f2eb2f20fd23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_64a29a4f-ee76-4e62-b09c-62f7c19e565f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:to="loc_us-gaap_PaymentsForRestructuring_64a29a4f-ee76-4e62-b09c-62f7c19e565f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_d150d033-b3a9-4597-83c5-2326fa578db4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringAndRelatedCostIncurredCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:to="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_d150d033-b3a9-4597-83c5-2326fa578db4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveTranslationAndOtherAdjustment_caa6f71f-38cc-440d-a994-f1129195506a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserveTranslationAndOtherAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_b2da6599-cd66-4cd0-bd93-40030dc2faf9" xlink:to="loc_us-gaap_RestructuringReserveTranslationAndOtherAdjustment_caa6f71f-38cc-440d-a994-f1129195506a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_ec5bf8d4-cdf2-465c-987b-3b672a723d9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_944ac60c-8834-4850-b502-9f8cba4f60ec" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_b953e5bc-2e53-4f36-81f0-6bb1128a3634" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_b953e5bc-2e53-4f36-81f0-6bb1128a3634" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_b953e5bc-2e53-4f36-81f0-6bb1128a3634_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_b953e5bc-2e53-4f36-81f0-6bb1128a3634" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_b953e5bc-2e53-4f36-81f0-6bb1128a3634_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_cf38623c-2f00-4fce-afdc-77685c41cbf0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_b953e5bc-2e53-4f36-81f0-6bb1128a3634" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_cf38623c-2f00-4fce-afdc-77685c41cbf0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeSeveranceMember_b395d7a2-f78f-4e2a-a739-ebb3ef3d87af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeSeveranceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_cf38623c-2f00-4fce-afdc-77685c41cbf0" xlink:to="loc_us-gaap_EmployeeSeveranceMember_b395d7a2-f78f-4e2a-a739-ebb3ef3d87af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_cccb4cd2-cbc1-40d5-880c-64a9b14f5588" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_cf38623c-2f00-4fce-afdc-77685c41cbf0" xlink:to="loc_us-gaap_OtherRestructuringMember_cccb4cd2-cbc1-40d5-880c-64a9b14f5588" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_ccde8b2d-9ac3-46ae-80eb-17c880a55464" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_ccde8b2d-9ac3-46ae-80eb-17c880a55464" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_ccde8b2d-9ac3-46ae-80eb-17c880a55464_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_ccde8b2d-9ac3-46ae-80eb-17c880a55464" xlink:to="loc_us-gaap_SegmentDomain_ccde8b2d-9ac3-46ae-80eb-17c880a55464_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_ccde8b2d-9ac3-46ae-80eb-17c880a55464" xlink:to="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DevelopedMarketsSegmentMember_bf21e7a1-ca82-4042-95c9-894c3779c2b8" xlink:href="vtrs-20220630.xsd#vtrs_DevelopedMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:to="loc_vtrs_DevelopedMarketsSegmentMember_bf21e7a1-ca82-4042-95c9-894c3779c2b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_GreaterChinaSegmentMember_32c63e4b-92a9-4467-adc9-4366afc27bbc" xlink:href="vtrs-20220630.xsd#vtrs_GreaterChinaSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:to="loc_vtrs_GreaterChinaSegmentMember_32c63e4b-92a9-4467-adc9-4366afc27bbc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_6fe84e53-0ed8-467e-a571-a38045d4dc1a" xlink:href="vtrs-20220630.xsd#vtrs_JapanAustraliaAndNewZealandSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:to="loc_vtrs_JapanAustraliaAndNewZealandSegmentMember_6fe84e53-0ed8-467e-a571-a38045d4dc1a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EmergingMarketsSegmentMember_e01265bf-3b62-47d5-ba98-888f26ad6670" xlink:href="vtrs-20220630.xsd#vtrs_EmergingMarketsSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:to="loc_vtrs_EmergingMarketsSegmentMember_e01265bf-3b62-47d5-ba98-888f26ad6670" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateAndOtherMember_43817e2b-c4d8-4560-9985-d88c8bff5deb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CorporateAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_73f413b3-6b41-4c4c-81fa-a247fa790f07" xlink:to="loc_us-gaap_CorporateAndOtherMember_43817e2b-c4d8-4560-9985-d88c8bff5deb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_d9462759-db6b-42a2-acd3-da4812d5fad0" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:to="loc_srt_RangeAxis_d9462759-db6b-42a2-acd3-da4812d5fad0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d9462759-db6b-42a2-acd3-da4812d5fad0_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_d9462759-db6b-42a2-acd3-da4812d5fad0" xlink:to="loc_srt_RangeMember_d9462759-db6b-42a2-acd3-da4812d5fad0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c381fb27-e0a1-4ce5-8fe1-5cc2169d5c44" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_d9462759-db6b-42a2-acd3-da4812d5fad0" xlink:to="loc_srt_RangeMember_c381fb27-e0a1-4ce5-8fe1-5cc2169d5c44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_4ab15146-8bed-41a1-9f31-98e715093cd6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c381fb27-e0a1-4ce5-8fe1-5cc2169d5c44" xlink:to="loc_srt_MinimumMember_4ab15146-8bed-41a1-9f31-98e715093cd6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_dee13d14-eb20-4dd4-9747-17c0b3642f87" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c381fb27-e0a1-4ce5-8fe1-5cc2169d5c44" xlink:to="loc_srt_MaximumMember_dee13d14-eb20-4dd4-9747-17c0b3642f87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_7d3ac693-e1aa-473a-bd7f-a40646cce5db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:to="loc_us-gaap_RestructuringPlanAxis_7d3ac693-e1aa-473a-bd7f-a40646cce5db" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_7d3ac693-e1aa-473a-bd7f-a40646cce5db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_7d3ac693-e1aa-473a-bd7f-a40646cce5db" xlink:to="loc_us-gaap_RestructuringPlanDomain_7d3ac693-e1aa-473a-bd7f-a40646cce5db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_d9d6cd7f-117d-4323-b326-8ce4d28c9b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_7d3ac693-e1aa-473a-bd7f-a40646cce5db" xlink:to="loc_us-gaap_RestructuringPlanDomain_d9d6cd7f-117d-4323-b326-8ce4d28c9b3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_A2020RestructuringPlanMember_35f20c72-800d-4248-8c7c-4139cfeed2be" xlink:href="vtrs-20220630.xsd#vtrs_A2020RestructuringPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_d9d6cd7f-117d-4323-b326-8ce4d28c9b3e" xlink:to="loc_vtrs_A2020RestructuringPlanMember_35f20c72-800d-4248-8c7c-4139cfeed2be" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_869c7dda-5413-4c52-9f61-cc10498acd44" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_59a0001a-f769-4947-a620-e037f5721223" xlink:to="loc_srt_StatementScenarioAxis_869c7dda-5413-4c52-9f61-cc10498acd44" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_869c7dda-5413-4c52-9f61-cc10498acd44_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_869c7dda-5413-4c52-9f61-cc10498acd44" xlink:to="loc_srt_ScenarioUnspecifiedDomain_869c7dda-5413-4c52-9f61-cc10498acd44_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_4703b262-3905-499a-b1f4-dfdd16e858b6" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_869c7dda-5413-4c52-9f61-cc10498acd44" xlink:to="loc_srt_ScenarioUnspecifiedDomain_4703b262-3905-499a-b1f4-dfdd16e858b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_8c1098a8-044d-4755-a54e-849ae6bdbbc4" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_4703b262-3905-499a-b1f4-dfdd16e858b6" xlink:to="loc_srt_ScenarioForecastMember_8c1098a8-044d-4755-a54e-849ae6bdbbc4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CollaborationandLicensingAgreementsDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#CollaborationandLicensingAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/CollaborationandLicensingAgreementsDetails" xlink:type="extended" id="i717468711e2348b09c311f73ab1a62c5_CollaborationandLicensingAgreementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_b1553339-ba86-4cb7-847d-9a1ba0387fa7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Developmentandsalesmilestonepayments_5545bbd7-9ad6-4f86-b3a0-19ccc5cbd802" xlink:href="vtrs-20220630.xsd#vtrs_Developmentandsalesmilestonepayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_b1553339-ba86-4cb7-847d-9a1ba0387fa7" xlink:to="loc_vtrs_Developmentandsalesmilestonepayments_5545bbd7-9ad6-4f86-b3a0-19ccc5cbd802" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7064bbea-4a87-43b9-8a97-1548956e26d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_b1553339-ba86-4cb7-847d-9a1ba0387fa7" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7064bbea-4a87-43b9-8a97-1548956e26d0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_4a5b7557-8056-467c-ab1a-271f6392158a" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7064bbea-4a87-43b9-8a97-1548956e26d0" xlink:to="loc_srt_RangeAxis_4a5b7557-8056-467c-ab1a-271f6392158a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4a5b7557-8056-467c-ab1a-271f6392158a_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_4a5b7557-8056-467c-ab1a-271f6392158a" xlink:to="loc_srt_RangeMember_4a5b7557-8056-467c-ab1a-271f6392158a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c3a9488b-cb0f-4371-acf9-874c662f31ac" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_4a5b7557-8056-467c-ab1a-271f6392158a" xlink:to="loc_srt_RangeMember_c3a9488b-cb0f-4371-acf9-874c662f31ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_238fa5a6-559a-4a5b-897a-17566fca4cd5" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c3a9488b-cb0f-4371-acf9-874c662f31ac" xlink:to="loc_srt_MaximumMember_238fa5a6-559a-4a5b-897a-17566fca4cd5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_019b4dba-3074-45e7-baba-ddad20f510ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_7064bbea-4a87-43b9-8a97-1548956e26d0" xlink:to="loc_us-gaap_TypeOfArrangementAxis_019b4dba-3074-45e7-baba-ddad20f510ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4dba-3074-45e7-baba-ddad20f510ab_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b4dba-3074-45e7-baba-ddad20f510ab" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_019b4dba-3074-45e7-baba-ddad20f510ab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a36de8af-9b0f-448a-96b3-4190908d4fd3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_019b4dba-3074-45e7-baba-ddad20f510ab" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a36de8af-9b0f-448a-96b3-4190908d4fd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_d0c11e64-08e7-4b40-847d-1ff1c09f17da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a36de8af-9b0f-448a-96b3-4190908d4fd3" xlink:to="loc_us-gaap_CollaborativeArrangementMember_d0c11e64-08e7-4b40-847d-1ff1c09f17da" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/IncomeTaxesIncomeTaxesDisclosureDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#IncomeTaxesIncomeTaxesDisclosureDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/IncomeTaxesIncomeTaxesDisclosureDetails" xlink:type="extended" id="i0f317d7b5508483f814345a2221a26f4_IncomeTaxesIncomeTaxesDisclosureDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_779976ac-988c-4aa1-9809-8113432b96fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ReserveForUncertainTaxPositionsIncludingInterestAndPenalties_fbf8d842-02b3-4b68-b662-f69bc5d3a64e" xlink:href="vtrs-20220630.xsd#vtrs_ReserveForUncertainTaxPositionsIncludingInterestAndPenalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_779976ac-988c-4aa1-9809-8113432b96fa" xlink:to="loc_vtrs_ReserveForUncertainTaxPositionsIncludingInterestAndPenalties_fbf8d842-02b3-4b68-b662-f69bc5d3a64e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_IncomeTaxExaminationPartialPaymentOfIncomeTaxExpense_df996b72-a936-4bfe-ac07-3fe047452501" xlink:href="vtrs-20220630.xsd#vtrs_IncomeTaxExaminationPartialPaymentOfIncomeTaxExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_779976ac-988c-4aa1-9809-8113432b96fa" xlink:to="loc_vtrs_IncomeTaxExaminationPartialPaymentOfIncomeTaxExpense_df996b72-a936-4bfe-ac07-3fe047452501" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_57841d85-1b64-43c3-bf69-f704e86de932" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_779976ac-988c-4aa1-9809-8113432b96fa" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_57841d85-1b64-43c3-bf69-f704e86de932" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_57841d85-1b64-43c3-bf69-f704e86de932" xlink:to="loc_srt_StatementScenarioAxis_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e" xlink:to="loc_srt_ScenarioUnspecifiedDomain_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_6184d028-348a-411e-90b4-703af82cc3da" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_616c6fce-742c-4b29-8ad4-b2f0fb3a7b1e" xlink:to="loc_srt_ScenarioUnspecifiedDomain_6184d028-348a-411e-90b4-703af82cc3da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_d49d805b-93f5-48fa-a3c5-c23c927aabdc" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_6184d028-348a-411e-90b4-703af82cc3da" xlink:to="loc_srt_ScenarioForecastMember_d49d805b-93f5-48fa-a3c5-c23c927aabdc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_470eda23-81b6-4f9c-898c-04a5b6c62d96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_57841d85-1b64-43c3-bf69-f704e86de932" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_470eda23-81b6-4f9c-898c-04a5b6c62d96" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_470eda23-81b6-4f9c-898c-04a5b6c62d96_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_470eda23-81b6-4f9c-898c-04a5b6c62d96" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_470eda23-81b6-4f9c-898c-04a5b6c62d96_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_093575ab-8704-484a-a79e-ce9403d00690" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_470eda23-81b6-4f9c-898c-04a5b6c62d96" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_093575ab-8704-484a-a79e-ce9403d00690" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_8fc2c597-017a-4fa4-891a-325b8bca249b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_093575ab-8704-484a-a79e-ce9403d00690" xlink:to="loc_us-gaap_ForeignCountryMember_8fc2c597-017a-4fa4-891a-325b8bca249b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_d450f775-59fb-47fc-bcc9-71f35d144154" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_57841d85-1b64-43c3-bf69-f704e86de932" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameAxis_d450f775-59fb-47fc-bcc9-71f35d144154" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_d450f775-59fb-47fc-bcc9-71f35d144154_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_d450f775-59fb-47fc-bcc9-71f35d144154" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_d450f775-59fb-47fc-bcc9-71f35d144154_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_62b994a4-8fcb-4829-a1f5-ed51f172c6be" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_d450f775-59fb-47fc-bcc9-71f35d144154" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_62b994a4-8fcb-4829-a1f5-ed51f172c6be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AustralianTaxationOfficeMember_ed968cf8-7ec1-48b2-ace8-614ef89120bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AustralianTaxationOfficeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_62b994a4-8fcb-4829-a1f5-ed51f172c6be" xlink:to="loc_us-gaap_AustralianTaxationOfficeMember_ed968cf8-7ec1-48b2-ace8-614ef89120bc" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationLorazepamandClorazepateNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationLorazepamandClorazepateNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationLorazepamandClorazepateNarrativeDetails" xlink:type="extended" id="ia5a94f02f8af4f9a9e36470fc6163d53_LitigationLorazepamandClorazepateNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_7ca229be-a78e-40f7-8f0e-e151817d80ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_2c449584-9248-48d9-b133-9f2265f62bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7ca229be-a78e-40f7-8f0e-e151817d80ec" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_2c449584-9248-48d9-b133-9f2265f62bf7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EstimatedLitigationLiabilityReductionForPayments_69475140-5404-44a0-8955-4e20c4386390" xlink:href="vtrs-20220630.xsd#vtrs_EstimatedLitigationLiabilityReductionForPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7ca229be-a78e-40f7-8f0e-e151817d80ec" xlink:to="loc_vtrs_EstimatedLitigationLiabilityReductionForPayments_69475140-5404-44a0-8955-4e20c4386390" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_fabd7388-558e-46b7-88d5-91b165a0a8d4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_7ca229be-a78e-40f7-8f0e-e151817d80ec" xlink:to="loc_us-gaap_LossContingenciesTable_fabd7388-558e-46b7-88d5-91b165a0a8d4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_fabd7388-558e-46b7-88d5-91b165a0a8d4" xlink:to="loc_srt_LitigationCaseAxis_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec" xlink:to="loc_srt_LitigationCaseTypeDomain_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_f957e488-2f77-4810-9fc6-8b20a586625f" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_0e94ad2c-bdcd-4cc6-b13f-e1367ca7c7ec" xlink:to="loc_srt_LitigationCaseTypeDomain_f957e488-2f77-4810-9fc6-8b20a586625f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_262ab976-5469-4614-816d-0362bbc8d596" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_fabd7388-558e-46b7-88d5-91b165a0a8d4" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_262ab976-5469-4614-816d-0362bbc8d596" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_262ab976-5469-4614-816d-0362bbc8d596_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_262ab976-5469-4614-816d-0362bbc8d596" xlink:to="loc_us-gaap_LossContingencyNatureDomain_262ab976-5469-4614-816d-0362bbc8d596_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_d0c28642-a4d0-4e66-a3e7-52db85e527ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_262ab976-5469-4614-816d-0362bbc8d596" xlink:to="loc_us-gaap_LossContingencyNatureDomain_d0c28642-a4d0-4e66-a3e7-52db85e527ce" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationPricingandMedicaidLitigationNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationPricingandMedicaidLitigationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationPricingandMedicaidLitigationNarrativeDetails" xlink:type="extended" id="i9fe05aa7daaa40f8b4375dbef299d449_LitigationPricingandMedicaidLitigationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_277e5744-50a2-4dcd-9627-aaea117aee5c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_1f3b915b-4a23-4bf6-b203-32e4fe8b03af" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_277e5744-50a2-4dcd-9627-aaea117aee5c" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_1f3b915b-4a23-4bf6-b203-32e4fe8b03af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_785feda6-b6c3-497f-b4eb-ea204c9b7e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_277e5744-50a2-4dcd-9627-aaea117aee5c" xlink:to="loc_us-gaap_LossContingenciesTable_785feda6-b6c3-497f-b4eb-ea204c9b7e8f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_e48a3995-057e-4f18-988d-7316f0d7e9b9" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_785feda6-b6c3-497f-b4eb-ea204c9b7e8f" xlink:to="loc_srt_LitigationCaseAxis_e48a3995-057e-4f18-988d-7316f0d7e9b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_e48a3995-057e-4f18-988d-7316f0d7e9b9_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_e48a3995-057e-4f18-988d-7316f0d7e9b9" xlink:to="loc_srt_LitigationCaseTypeDomain_e48a3995-057e-4f18-988d-7316f0d7e9b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_6e9af95a-c8ff-43f0-bebc-dce0d3ff81bd" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_e48a3995-057e-4f18-988d-7316f0d7e9b9" xlink:to="loc_srt_LitigationCaseTypeDomain_6e9af95a-c8ff-43f0-bebc-dce0d3ff81bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_8481b482-f460-4162-8773-3a6cb8b5c903" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_785feda6-b6c3-497f-b4eb-ea204c9b7e8f" xlink:to="loc_dei_LegalEntityAxis_8481b482-f460-4162-8773-3a6cb8b5c903" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8481b482-f460-4162-8773-3a6cb8b5c903_default" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_8481b482-f460-4162-8773-3a6cb8b5c903" xlink:to="loc_dei_EntityDomain_8481b482-f460-4162-8773-3a6cb8b5c903_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_8642d13b-4629-412a-a40a-d24efc1ce167" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_8481b482-f460-4162-8773-3a6cb8b5c903" xlink:to="loc_dei_EntityDomain_8642d13b-4629-412a-a40a-d24efc1ce167" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_e596a8e5-031d-4b36-898c-643d01e71e33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_785feda6-b6c3-497f-b4eb-ea204c9b7e8f" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_e596a8e5-031d-4b36-898c-643d01e71e33" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_e596a8e5-031d-4b36-898c-643d01e71e33_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_e596a8e5-031d-4b36-898c-643d01e71e33" xlink:to="loc_us-gaap_LossContingencyNatureDomain_e596a8e5-031d-4b36-898c-643d01e71e33_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_7e40ae95-592b-4448-9625-e2ebbd862f72" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_e596a8e5-031d-4b36-898c-643d01e71e33" xlink:to="loc_us-gaap_LossContingencyNatureDomain_7e40ae95-592b-4448-9625-e2ebbd862f72" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationModafinilAntitrustLitigationandFTCInquiryNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationModafinilAntitrustLitigationandFTCInquiryNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationModafinilAntitrustLitigationandFTCInquiryNarrativeDetails" xlink:type="extended" id="i62f0c67873b1440ba8618f9b1ba36a38_LitigationModafinilAntitrustLitigationandFTCInquiryNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_457ba5ef-09a9-4b7c-8519-68a7d178f39e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Numberofstates_a312b414-9491-4ad5-8edb-deb6585f1b1e" xlink:href="vtrs-20220630.xsd#vtrs_Numberofstates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_457ba5ef-09a9-4b7c-8519-68a7d178f39e" xlink:to="loc_vtrs_Numberofstates_a312b414-9491-4ad5-8edb-deb6585f1b1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_22487f86-3f1f-426b-901d-ef7f1e8172c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_457ba5ef-09a9-4b7c-8519-68a7d178f39e" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_22487f86-3f1f-426b-901d-ef7f1e8172c4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EstimatedLitigationLiabilityReductionForPayments_a4752cb4-aba5-4360-9930-46fbffeba5fb" xlink:href="vtrs-20220630.xsd#vtrs_EstimatedLitigationLiabilityReductionForPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_457ba5ef-09a9-4b7c-8519-68a7d178f39e" xlink:to="loc_vtrs_EstimatedLitigationLiabilityReductionForPayments_a4752cb4-aba5-4360-9930-46fbffeba5fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_e5eb3a0f-f306-417e-bbee-c9ed335f950d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_457ba5ef-09a9-4b7c-8519-68a7d178f39e" xlink:to="loc_us-gaap_LossContingenciesTable_e5eb3a0f-f306-417e-bbee-c9ed335f950d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_9befbbbb-1248-4191-a457-8e2789a261f8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_e5eb3a0f-f306-417e-bbee-c9ed335f950d" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_9befbbbb-1248-4191-a457-8e2789a261f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_9befbbbb-1248-4191-a457-8e2789a261f8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9befbbbb-1248-4191-a457-8e2789a261f8" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_9befbbbb-1248-4191-a457-8e2789a261f8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_fcf5d4b0-89d6-4f6c-a034-eea06488fb92" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9befbbbb-1248-4191-a457-8e2789a261f8" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_fcf5d4b0-89d6-4f6c-a034-eea06488fb92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_0bebe1f2-cc62-460e-9cf1-1b592f12f801" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_fcf5d4b0-89d6-4f6c-a034-eea06488fb92" xlink:to="loc_us-gaap_SubsequentEventMember_0bebe1f2-cc62-460e-9cf1-1b592f12f801" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_6f9d8e17-1c71-49d9-8d83-d98435107465" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_e5eb3a0f-f306-417e-bbee-c9ed335f950d" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_6f9d8e17-1c71-49d9-8d83-d98435107465" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_6f9d8e17-1c71-49d9-8d83-d98435107465_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_6f9d8e17-1c71-49d9-8d83-d98435107465" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_6f9d8e17-1c71-49d9-8d83-d98435107465_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_38d41a3b-3967-47d7-8fa0-20ddfda0111c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_6f9d8e17-1c71-49d9-8d83-d98435107465" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_38d41a3b-3967-47d7-8fa0-20ddfda0111c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_12f4d5bd-2d6f-462b-8e00-30d7389a5343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_38d41a3b-3967-47d7-8fa0-20ddfda0111c" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_12f4d5bd-2d6f-462b-8e00-30d7389a5343" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationMDRPClassificationofEpiPenAutoInjectorandEpiPenJrAutoInjectorDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationMDRPClassificationofEpiPenAutoInjectorandEpiPenJrAutoInjectorDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationMDRPClassificationofEpiPenAutoInjectorandEpiPenJrAutoInjectorDetails" xlink:type="extended" id="i01ab6b85f0e04857af4083cd9fff4357_LitigationMDRPClassificationofEpiPenAutoInjectorandEpiPenJrAutoInjectorDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_c2bbcdab-174e-47cd-95ed-55b26a1239cf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_c2bbcdab-174e-47cd-95ed-55b26a1239cf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Numberofstates_97e25db4-9d7a-4f74-bc63-672101c6784a" xlink:href="vtrs-20220630.xsd#vtrs_Numberofstates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:to="loc_vtrs_Numberofstates_97e25db4-9d7a-4f74-bc63-672101c6784a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserve_aa82b24f-8c21-4840-8a04-ea96e6b6db2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:to="loc_us-gaap_LitigationReserve_aa82b24f-8c21-4840-8a04-ea96e6b6db2e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForLegalSettlements_6e4b3098-9d5e-45d2-8b32-709f3dbeeee9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForLegalSettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:to="loc_us-gaap_PaymentsForLegalSettlements_6e4b3098-9d5e-45d2-8b32-709f3dbeeee9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_5a8310e8-f999-4645-a95d-1565f5743f62" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_15c795dc-e3c9-453b-8a5d-310167e92d4d" xlink:to="loc_us-gaap_LossContingenciesTable_5a8310e8-f999-4645-a95d-1565f5743f62" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_0cf88da0-38e6-403e-9711-fdfbf32fcc9b" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_5a8310e8-f999-4645-a95d-1565f5743f62" xlink:to="loc_srt_LitigationCaseAxis_0cf88da0-38e6-403e-9711-fdfbf32fcc9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0cf88da0-38e6-403e-9711-fdfbf32fcc9b_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_0cf88da0-38e6-403e-9711-fdfbf32fcc9b" xlink:to="loc_srt_LitigationCaseTypeDomain_0cf88da0-38e6-403e-9711-fdfbf32fcc9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_70ff6397-6e5a-420c-91f9-42f9ac170306" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_0cf88da0-38e6-403e-9711-fdfbf32fcc9b" xlink:to="loc_srt_LitigationCaseTypeDomain_70ff6397-6e5a-420c-91f9-42f9ac170306" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_EpiPenAutoInjectorLitigationMember_8bc79b9c-1d27-4d02-be3c-3b364d30f3cb" xlink:href="vtrs-20220630.xsd#vtrs_EpiPenAutoInjectorLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_70ff6397-6e5a-420c-91f9-42f9ac170306" xlink:to="loc_vtrs_EpiPenAutoInjectorLitigationMember_8bc79b9c-1d27-4d02-be3c-3b364d30f3cb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_3c829b54-574f-4402-ba66-33e77b4de2e2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_5a8310e8-f999-4645-a95d-1565f5743f62" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_3c829b54-574f-4402-ba66-33e77b4de2e2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_3c829b54-574f-4402-ba66-33e77b4de2e2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3c829b54-574f-4402-ba66-33e77b4de2e2" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_3c829b54-574f-4402-ba66-33e77b4de2e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_9cb50f85-b5cc-475b-a1f9-660ee6229ca3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3c829b54-574f-4402-ba66-33e77b4de2e2" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_9cb50f85-b5cc-475b-a1f9-660ee6229ca3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_ac1cceb7-678c-48d8-8136-e8ec4138579b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_9cb50f85-b5cc-475b-a1f9-660ee6229ca3" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_ac1cceb7-678c-48d8-8136-e8ec4138579b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_73776c0f-65cf-4021-bb4c-c9cbc872fc03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_5a8310e8-f999-4645-a95d-1565f5743f62" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_73776c0f-65cf-4021-bb4c-c9cbc872fc03" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_73776c0f-65cf-4021-bb4c-c9cbc872fc03_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_73776c0f-65cf-4021-bb4c-c9cbc872fc03" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_73776c0f-65cf-4021-bb4c-c9cbc872fc03_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_3d93a821-02ab-4ead-b825-bbf3b03b24ef" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_73776c0f-65cf-4021-bb4c-c9cbc872fc03" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_3d93a821-02ab-4ead-b825-bbf3b03b24ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_9bee98b3-26bb-45b3-9acc-d485487340b7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_3d93a821-02ab-4ead-b825-bbf3b03b24ef" xlink:to="loc_us-gaap_SubsequentEventMember_9bee98b3-26bb-45b3-9acc-d485487340b7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationDrugPricingMattersDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationDrugPricingMattersDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationDrugPricingMattersDetails" xlink:type="extended" id="ic5a2d1fb366c4c909d88d308d2904987_LitigationDrugPricingMattersDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_41de2b2d-2b6d-4c45-b8a0-1e25a52c4f58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Numberofstates_d20b72de-df69-4f27-bdbc-0ac88898165a" xlink:href="vtrs-20220630.xsd#vtrs_Numberofstates"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_41de2b2d-2b6d-4c45-b8a0-1e25a52c4f58" xlink:to="loc_vtrs_Numberofstates_d20b72de-df69-4f27-bdbc-0ac88898165a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_b2dcb22c-fea6-4efc-882d-c37733047ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_41de2b2d-2b6d-4c45-b8a0-1e25a52c4f58" xlink:to="loc_us-gaap_LossContingenciesTable_b2dcb22c-fea6-4efc-882d-c37733047ce0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_4498a781-b635-47e1-b8ab-decebf1c6456" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_b2dcb22c-fea6-4efc-882d-c37733047ce0" xlink:to="loc_srt_LitigationCaseAxis_4498a781-b635-47e1-b8ab-decebf1c6456" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_4498a781-b635-47e1-b8ab-decebf1c6456_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_4498a781-b635-47e1-b8ab-decebf1c6456" xlink:to="loc_srt_LitigationCaseTypeDomain_4498a781-b635-47e1-b8ab-decebf1c6456_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_4498a781-b635-47e1-b8ab-decebf1c6456" xlink:to="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_MultiDistrictLitigationMember_4754d0d5-8f96-4193-ad3e-655e1b8dab25" xlink:href="vtrs-20220630.xsd#vtrs_MultiDistrictLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:to="loc_vtrs_MultiDistrictLitigationMember_4754d0d5-8f96-4193-ad3e-655e1b8dab25" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AnticompetitiveConductwithDoxycyclineHyclateDelayedReleaseDoxycyclineMonohydrateGlipizideMetforminandVerapamilMember_a1fcc74a-ae35-4499-be74-4ea06a0f3da4" xlink:href="vtrs-20220630.xsd#vtrs_AnticompetitiveConductwithDoxycyclineHyclateDelayedReleaseDoxycyclineMonohydrateGlipizideMetforminandVerapamilMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:to="loc_vtrs_AnticompetitiveConductwithDoxycyclineHyclateDelayedReleaseDoxycyclineMonohydrateGlipizideMetforminandVerapamilMember_a1fcc74a-ae35-4499-be74-4ea06a0f3da4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AnticompetitiveConductwithGenericDrugsMember_4a385a31-b03f-452f-b09c-c69dd1507990" xlink:href="vtrs-20220630.xsd#vtrs_AnticompetitiveConductwithGenericDrugsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:to="loc_vtrs_AnticompetitiveConductwithGenericDrugsMember_4a385a31-b03f-452f-b09c-c69dd1507990" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AmendedAnticompetitiveConductwithGenericDrugsMember_88b092ec-1be6-4bed-b5af-7f3bc178551f" xlink:href="vtrs-20220630.xsd#vtrs_AmendedAnticompetitiveConductwithGenericDrugsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_6317dd55-18e6-4f69-9f8d-d193696795af" xlink:to="loc_vtrs_AmendedAnticompetitiveConductwithGenericDrugsMember_88b092ec-1be6-4bed-b5af-7f3bc178551f" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationEuropeanCommissionProceedingsNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationEuropeanCommissionProceedingsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationEuropeanCommissionProceedingsNarrativeDetails" xlink:type="extended" id="ic765b7b8888345279104e8b3c4eeef99_LitigationEuropeanCommissionProceedingsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_0d630cb1-ae9a-4e84-933a-d29dfe0ba7ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesPaidValue_77747186-36fa-45f0-a834-cdb068e6e833" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyDamagesPaidValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0d630cb1-ae9a-4e84-933a-d29dfe0ba7ec" xlink:to="loc_us-gaap_LossContingencyDamagesPaidValue_77747186-36fa-45f0-a834-cdb068e6e833" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_1bd96fc6-8d5a-4cce-b7c8-7bc8e125727b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0d630cb1-ae9a-4e84-933a-d29dfe0ba7ec" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_1bd96fc6-8d5a-4cce-b7c8-7bc8e125727b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_82d48e86-ee06-4316-92b0-46b62b675429" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_0d630cb1-ae9a-4e84-933a-d29dfe0ba7ec" xlink:to="loc_us-gaap_LossContingenciesTable_82d48e86-ee06-4316-92b0-46b62b675429" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_0bdab169-d660-4fdb-bb7b-c0662567bb92" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_82d48e86-ee06-4316-92b0-46b62b675429" xlink:to="loc_srt_ConsolidatedEntitiesAxis_0bdab169-d660-4fdb-bb7b-c0662567bb92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_0bdab169-d660-4fdb-bb7b-c0662567bb92_default" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_0bdab169-d660-4fdb-bb7b-c0662567bb92" xlink:to="loc_srt_ConsolidatedEntitiesDomain_0bdab169-d660-4fdb-bb7b-c0662567bb92_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_f24519e0-5c7f-49bc-aaf5-32d1db9b3322" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_0bdab169-d660-4fdb-bb7b-c0662567bb92" xlink:to="loc_srt_ConsolidatedEntitiesDomain_f24519e0-5c7f-49bc-aaf5-32d1db9b3322" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ParentCompanyMember_aecfaa83-5db4-446f-aee0-744464c65c92" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_ParentCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_f24519e0-5c7f-49bc-aaf5-32d1db9b3322" xlink:to="loc_srt_ParentCompanyMember_aecfaa83-5db4-446f-aee0-744464c65c92" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationProductLiabilityNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationProductLiabilityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationProductLiabilityNarrativeDetails" xlink:type="extended" id="i64115e06078347eebeca93c1790c903b_LitigationProductLiabilityNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_5b57831c-761d-4369-9d3a-81ce30ef23cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_5c9513e5-071d-4eb9-8bcf-04a052e70527" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_5b57831c-761d-4369-9d3a-81ce30ef23cd" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_5c9513e5-071d-4eb9-8bcf-04a052e70527" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_b3d7dec6-e3c7-402d-b6eb-66e62e6bea7b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_5b57831c-761d-4369-9d3a-81ce30ef23cd" xlink:to="loc_us-gaap_LossContingenciesTable_b3d7dec6-e3c7-402d-b6eb-66e62e6bea7b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_8c0e56df-c426-4ab7-80a4-a456d58d22b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_b3d7dec6-e3c7-402d-b6eb-66e62e6bea7b" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_8c0e56df-c426-4ab7-80a4-a456d58d22b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_8c0e56df-c426-4ab7-80a4-a456d58d22b0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_8c0e56df-c426-4ab7-80a4-a456d58d22b0" xlink:to="loc_us-gaap_LossContingencyNatureDomain_8c0e56df-c426-4ab7-80a4-a456d58d22b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_11691898-be43-4fdf-9b66-847745827cec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_8c0e56df-c426-4ab7-80a4-a456d58d22b0" xlink:to="loc_us-gaap_LossContingencyNatureDomain_11691898-be43-4fdf-9b66-847745827cec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProductLiabilityMember_46cdf704-ace3-456f-a4ae-5b44d4f794bb" xlink:href="vtrs-20220630.xsd#vtrs_ProductLiabilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_11691898-be43-4fdf-9b66-847745827cec" xlink:to="loc_vtrs_ProductLiabilityMember_46cdf704-ace3-456f-a4ae-5b44d4f794bb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationIntellectualPropertyNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationIntellectualPropertyNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationIntellectualPropertyNarrativeDetails" xlink:type="extended" id="i61aec8dc86e0448680699f9432c7fe52_LitigationIntellectualPropertyNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_c745a75d-a0a0-4e26-947d-413a762986cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_NumberOfTimesDamagesMayBeIncreasedInCasesOfWillfulInfringement_63438870-b992-46d3-8e63-eeb0061ad602" xlink:href="vtrs-20220630.xsd#vtrs_NumberOfTimesDamagesMayBeIncreasedInCasesOfWillfulInfringement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_c745a75d-a0a0-4e26-947d-413a762986cd" xlink:to="loc_vtrs_NumberOfTimesDamagesMayBeIncreasedInCasesOfWillfulInfringement_63438870-b992-46d3-8e63-eeb0061ad602" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesPaidValue_10c534af-1483-4511-a396-a9ada60e9853" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyDamagesPaidValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_c745a75d-a0a0-4e26-947d-413a762986cd" xlink:to="loc_us-gaap_LossContingencyDamagesPaidValue_10c534af-1483-4511-a396-a9ada60e9853" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_125e4763-313e-4fd4-8322-13cd92aa5486" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_c745a75d-a0a0-4e26-947d-413a762986cd" xlink:to="loc_us-gaap_LossContingenciesTable_125e4763-313e-4fd4-8322-13cd92aa5486" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_17d4ee66-a3dd-4950-967c-d866694b1bb4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_125e4763-313e-4fd4-8322-13cd92aa5486" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_17d4ee66-a3dd-4950-967c-d866694b1bb4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_17d4ee66-a3dd-4950-967c-d866694b1bb4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_17d4ee66-a3dd-4950-967c-d866694b1bb4" xlink:to="loc_us-gaap_LossContingencyNatureDomain_17d4ee66-a3dd-4950-967c-d866694b1bb4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_facbe45a-9ea6-4a79-87bc-e0ab91a7c995" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_17d4ee66-a3dd-4950-967c-d866694b1bb4" xlink:to="loc_us-gaap_LossContingencyNatureDomain_facbe45a-9ea6-4a79-87bc-e0ab91a7c995" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_2aedf0da-1f47-46c3-911e-315c9e94ec7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_facbe45a-9ea6-4a79-87bc-e0ab91a7c995" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_2aedf0da-1f47-46c3-911e-315c9e94ec7a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LitigationOtherLitigationNarrativeDetails" xlink:type="simple" xlink:href="vtrs-20220630.xsd#LitigationOtherLitigationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.viatris.com/role/LitigationOtherLitigationNarrativeDetails" xlink:type="extended" id="i4d37b857bc35423c82ee4b03a41eee18_LitigationOtherLitigationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_b35dba9c-2e9f-48c7-b372-23ec3d9fd83a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Numberofcases_e3abd8aa-e57c-47b7-a8af-6d2954269845" xlink:href="vtrs-20220630.xsd#vtrs_Numberofcases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_b35dba9c-2e9f-48c7-b372-23ec3d9fd83a" xlink:to="loc_vtrs_Numberofcases_e3abd8aa-e57c-47b7-a8af-6d2954269845" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyAccrualAtCarryingValue_40ca950f-ef99-4704-aa6c-84f5ba22bcba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyAccrualAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_b35dba9c-2e9f-48c7-b372-23ec3d9fd83a" xlink:to="loc_us-gaap_LossContingencyAccrualAtCarryingValue_40ca950f-ef99-4704-aa6c-84f5ba22bcba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_05388a6b-8055-4c01-82c0-227fff99b01c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_b35dba9c-2e9f-48c7-b372-23ec3d9fd83a" xlink:to="loc_us-gaap_LossContingenciesTable_05388a6b-8055-4c01-82c0-227fff99b01c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6c291d73-fada-43a6-88c4-b20df8d26033" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_05388a6b-8055-4c01-82c0-227fff99b01c" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6c291d73-fada-43a6-88c4-b20df8d26033" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_6c291d73-fada-43a6-88c4-b20df8d26033_default" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6c291d73-fada-43a6-88c4-b20df8d26033" xlink:to="loc_us-gaap_LossContingencyNatureDomain_6c291d73-fada-43a6-88c4-b20df8d26033_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_480a5d3e-62d1-4ef7-9dec-a2b0c7335ea6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_6c291d73-fada-43a6-88c4-b20df8d26033" xlink:to="loc_us-gaap_LossContingencyNatureDomain_480a5d3e-62d1-4ef7-9dec-a2b0c7335ea6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherMember_5c44585d-2a6b-4c51-a22e-69836df0d46b" xlink:href="vtrs-20220630.xsd#vtrs_OtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_480a5d3e-62d1-4ef7-9dec-a2b0c7335ea6" xlink:to="loc_vtrs_OtherMember_5c44585d-2a6b-4c51-a22e-69836df0d46b" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
