<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e0306-69a2-7f36-9d13-d4a92088bf17,g:3267a49f-6783-46e8-a871-34d56a25e1bc-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="simple" xlink:href="vtrs-20260630.xsd#CondensedConsolidatedStatementsOfOperations"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e0306-6b92-7a80-8127-a28567b5f3ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_019e0306-6b92-737d-adab-005d6f8832ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019e0306-6b92-7a80-8127-a28567b5f3ee" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_019e0306-6b92-737d-adab-005d6f8832ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e0306-6b92-722e-a84b-b4a0d9d27e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_019e0306-6b92-7a80-8127-a28567b5f3ee" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e0306-6b92-722e-a84b-b4a0d9d27e6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e0306-6b92-7334-aec1-a417513d5db7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019e0306-6b92-7265-bde1-b038eb7a2a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e0306-6b92-7334-aec1-a417513d5db7" xlink:to="loc_us-gaap_Revenues_019e0306-6b92-7265-bde1-b038eb7a2a3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019e0306-6b92-77f6-9918-eaca94fb1060" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e0306-6b92-7334-aec1-a417513d5db7" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019e0306-6b92-77f6-9918-eaca94fb1060" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-724e-98ba-36afab64ea53" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e0306-6b92-780a-9c55-fca9aedf00c7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-724e-98ba-36afab64ea53" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e0306-6b92-780a-9c55-fca9aedf00c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_019e0306-6b92-7e82-9696-9ca354cf2894" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-724e-98ba-36afab64ea53" xlink:to="loc_us-gaap_InterestExpense_019e0306-6b92-7e82-9696-9ca354cf2894" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e0306-6b92-7e54-abe2-c5b6c927fedd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-724e-98ba-36afab64ea53" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e0306-6b92-7e54-abe2-c5b6c927fedd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-7314-ab28-343b3d34aee5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-7558-800f-1cd698e7001a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-7314-ab28-343b3d34aee5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019e0306-6b92-7558-800f-1cd698e7001a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e0306-6b92-7c01-b9ce-0e84362dee9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-7314-ab28-343b3d34aee5" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e0306-6b92-7c01-b9ce-0e84362dee9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_019e0306-6b92-774d-97bf-2c0493c92d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_019e0306-6b92-774d-97bf-2c0493c92d5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherResearchAndDevelopmentExpenseRefund_019e0306-6b92-73ff-8617-8d71216f6491" xlink:href="vtrs-20260630.xsd#vtrs_OtherResearchAndDevelopmentExpenseRefund"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:to="loc_vtrs_OtherResearchAndDevelopmentExpenseRefund_019e0306-6b92-73ff-8617-8d71216f6491" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_019e0306-6b92-7c07-a4c4-8883263da4dc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_019e0306-6b92-7c07-a4c4-8883263da4dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e0306-6b92-7eb7-8fd3-e3de5c3b66b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e0306-6b92-7eb7-8fd3-e3de5c3b66b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e0306-6b92-7388-bfb9-6eb72693a84e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e0306-6b92-7b53-90e2-422ad004a51e" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019e0306-6b92-7388-bfb9-6eb72693a84e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e0306-6b92-7979-8cf6-cbf84adf04b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e0306-6b92-7225-b60f-eae0c2a93de3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e0306-6b92-7979-8cf6-cbf84adf04b5" xlink:to="loc_us-gaap_GrossProfit_019e0306-6b92-7225-b60f-eae0c2a93de3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e0306-6b92-7c98-9a1b-af7708acb793" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e0306-6b92-7979-8cf6-cbf84adf04b5" xlink:to="loc_us-gaap_OperatingExpenses_019e0306-6b92-7c98-9a1b-af7708acb793" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsofComprehensiveLossEarnings" xlink:type="simple" xlink:href="vtrs-20260630.xsd#CondensedConsolidatedStatementsofComprehensiveLossEarnings"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsofComprehensiveLossEarnings" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-707f-b18b-31a25c44173e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-71f0-80e4-4c3c759f6a93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-707f-b18b-31a25c44173e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-71f0-80e4-4c3c759f6a93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_019e0306-6b92-731f-9a10-1689981ed5d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-707f-b18b-31a25c44173e" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_019e0306-6b92-731f-9a10-1689981ed5d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e0306-6b92-7780-93c2-b138f01731dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-7385-9fa1-6964008ef8dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e0306-6b92-7780-93c2-b138f01731dd" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-7385-9fa1-6964008ef8dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-753b-9796-e90125d423ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e0306-6b92-7780-93c2-b138f01731dd" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-753b-9796-e90125d423ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-7d0b-9bc8-dc8c06d40e43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_019e0306-6b92-7299-b952-f38a9d1a204e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-7d0b-9bc8-dc8c06d40e43" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_019e0306-6b92-7299-b952-f38a9d1a204e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019e0306-6b92-7084-ac41-767659205061" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-7d0b-9bc8-dc8c06d40e43" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_019e0306-6b92-7084-ac41-767659205061" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019e0306-6b92-73b1-85c9-7d0b075f817f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-7d0b-9bc8-dc8c06d40e43" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_019e0306-6b92-73b1-85c9-7d0b075f817f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_019e0306-6b92-7cdc-becd-1746c565e6af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_019e0306-6b92-7d0b-9bc8-dc8c06d40e43" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_019e0306-6b92-7cdc-becd-1746c565e6af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="vtrs-20260630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-70df-b004-b95d46464cb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_019e0306-6b92-7800-b779-8f390794f1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-70df-b004-b95d46464cb5" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_019e0306-6b92-7800-b779-8f390794f1d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019e0306-6b92-7bdf-ad37-97c65e7f2dfe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-70df-b004-b95d46464cb5" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019e0306-6b92-7bdf-ad37-97c65e7f2dfe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_019e0306-6b92-70ee-baa5-5806d221663a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-70df-b004-b95d46464cb5" xlink:to="loc_us-gaap_LongTermDebtCurrent_019e0306-6b92-70ee-baa5-5806d221663a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b92-7c65-91e4-611b0220c70d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-70df-b004-b95d46464cb5" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b92-7c65-91e4-611b0220c70d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e0306-6b92-7702-b350-474495b2ad5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e0306-6b92-7d27-ba42-9712397a2462" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e0306-6b92-7702-b350-474495b2ad5a" xlink:to="loc_us-gaap_Liabilities_019e0306-6b92-7d27-ba42-9712397a2462" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e0306-6b92-7295-ba1e-23d76c037338" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e0306-6b92-7702-b350-474495b2ad5a" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e0306-6b92-7295-ba1e-23d76c037338" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e0306-6b92-77c1-ae6a-b1329654acf2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_AssetsCurrent_019e0306-6b92-77c1-ae6a-b1329654acf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e0306-6b92-779d-8cb6-e3b5dac76165" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e0306-6b92-779d-8cb6-e3b5dac76165" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e0306-6b92-7e3a-8e71-b491025f1ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e0306-6b92-7e3a-8e71-b491025f1ffd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e0306-6b92-7422-ae43-5040793d8bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_Goodwill_019e0306-6b92-7422-ae43-5040793d8bd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e0306-6b92-714d-9463-4450145676f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019e0306-6b92-714d-9463-4450145676f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b92-7ad7-a1eb-a4d25fd1e4f7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e0306-6b92-73aa-8a0f-1a744da8a1d5" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b92-7ad7-a1eb-a4d25fd1e4f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7660-9b3a-1dd315448207" xlink:href="vtrs-20260630.xsd#vtrs_StockholdersEquityParentBeforeTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e0306-6b92-75c2-b6ce-2d7a9ee27fb7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7660-9b3a-1dd315448207" xlink:to="loc_us-gaap_CommonStockValue_019e0306-6b92-75c2-b6ce-2d7a9ee27fb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019e0306-6b92-7159-964e-0908f1cabde4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7660-9b3a-1dd315448207" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019e0306-6b92-7159-964e-0908f1cabde4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e0306-6b92-7ded-9033-61446b849d3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7660-9b3a-1dd315448207" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e0306-6b92-7ded-9033-61446b849d3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-7a97-b412-d166eb12684c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7660-9b3a-1dd315448207" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e0306-6b92-7a97-b412-d166eb12684c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e0306-6b92-7191-ba01-3cee979c3d27" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e0306-6b92-76de-b354-bb30d2af082e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e0306-6b92-7191-ba01-3cee979c3d27" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e0306-6b92-76de-b354-bb30d2af082e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e0306-6b92-7406-8c23-1d1f22e762fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e0306-6b92-7191-ba01-3cee979c3d27" xlink:to="loc_us-gaap_InventoryNet_019e0306-6b92-7406-8c23-1d1f22e762fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e0306-6b92-7339-ae65-43e11f24868c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e0306-6b92-7191-ba01-3cee979c3d27" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e0306-6b92-7339-ae65-43e11f24868c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b92-7097-b496-ec35dc31f3f8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e0306-6b92-7191-ba01-3cee979c3d27" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b92-7097-b496-ec35dc31f3f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e0306-6b92-7cce-9221-b72359fec094" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-7834-9fca-e5eb5d1d98ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e0306-6b92-7cce-9221-b72359fec094" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e0306-6b92-7834-9fca-e5eb5d1d98ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e0306-6b92-7696-9d47-d0b0d2cd4508" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e0306-6b92-7cce-9221-b72359fec094" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e0306-6b92-7696-9d47-d0b0d2cd4508" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019e0306-6b92-779d-a2cd-e546744fb255" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e0306-6b92-7cce-9221-b72359fec094" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019e0306-6b92-779d-a2cd-e546744fb255" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b92-713d-a266-3e387ceaf15f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e0306-6b92-7cce-9221-b72359fec094" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b92-713d-a266-3e387ceaf15f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e0306-6b92-7647-9a79-a8f5168febb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7e67-aa8b-c51793635db2" xlink:href="vtrs-20260630.xsd#vtrs_StockholdersEquityParentBeforeTreasuryStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e0306-6b92-7647-9a79-a8f5168febb0" xlink:to="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_019e0306-6b92-7e67-aa8b-c51793635db2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_019e0306-6b92-77e2-818a-616a02e3a1b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_019e0306-6b92-7647-9a79-a8f5168febb0" xlink:to="loc_us-gaap_TreasuryStockValue_019e0306-6b92-77e2-818a-616a02e3a1b3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="vtrs-20260630.xsd#CondensedConsolidatedStatementsOfCashFlows"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-7226-9d6a-77c53d2e0cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_019e0306-6b92-7226-9d6a-77c53d2e0cb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e0306-6b92-76e4-bf81-c633b7b71062" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e0306-6b92-76e4-bf81-c633b7b71062" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e0306-6b92-7612-89e4-128f840d619b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_ShareBasedCompensation_019e0306-6b92-7612-89e4-128f840d619b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e0306-6b92-7612-b464-7918136e5212" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019e0306-6b92-7612-b464-7918136e5212" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_019e0306-6b92-7464-ae8e-52620e01cb86" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_019e0306-6b92-7464-ae8e-52620e01cb86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther_019e0306-6b92-7d53-85f0-42748ce1345e" xlink:href="vtrs-20260630.xsd#vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther_019e0306-6b92-7d53-85f0-42748ce1345e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_019e0306-6b92-7e4c-9f16-14f8e5f17c58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_019e0306-6b92-7e4c-9f16-14f8e5f17c58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019e0306-6b92-7384-95e6-2f3bd0af4fe7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019e0306-6b92-7384-95e6-2f3bd0af4fe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Changeinnoncashlitigationsettlementsnet_019e0306-6b92-751a-a5bc-ee74b6ba3404" xlink:href="vtrs-20260630.xsd#vtrs_Changeinnoncashlitigationsettlementsnet"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_vtrs_Changeinnoncashlitigationsettlementsnet_019e0306-6b92-751a-a5bc-ee74b6ba3404" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e0306-6b92-73ef-9da8-7f465ffd51cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e0306-6b92-73ef-9da8-7f465ffd51cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e0306-6b92-7320-8d4c-98c010044706" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e0306-6b92-7320-8d4c-98c010044706" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_019e0306-6b92-71df-b1a5-4f7df3264f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_019e0306-6b92-71df-b1a5-4f7df3264f9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019e0306-6b92-7fd9-8395-07bd8b3e6c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019e0306-6b92-7fd9-8395-07bd8b3e6c1f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019e0306-6b92-74f9-9a66-2bb1dd92c017" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7f08-8500-9ac8fa1eed9e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019e0306-6b92-74f9-9a66-2bb1dd92c017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e0306-6b92-77a8-8f23-0ed6bc469d90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e0306-6b92-70ec-8cf1-3102b6eab855" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e0306-6b92-77a8-8f23-0ed6bc469d90" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e0306-6b92-70ec-8cf1-3102b6eab855" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7fd0-8371-2bf6aa4468e5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e0306-6b92-77a8-8f23-0ed6bc469d90" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7fd0-8371-2bf6aa4468e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-7774-8d3c-4244cff7f012" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e0306-6b92-77a8-8f23-0ed6bc469d90" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-7774-8d3c-4244cff7f012" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7e0c-8bb8-49f7b226f420" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019e0306-6b92-77a8-8f23-0ed6bc469d90" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e0306-6b92-7e0c-8bb8-49f7b226f420" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_019e0306-6b92-7cb3-9a60-b9ea87e3fc8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_ProceedsFromSaleOfEquitySecuritiesFvNi_019e0306-6b92-7cb3-9a60-b9ea87e3fc8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e0306-6b92-79b9-84a1-cb1d15890cb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e0306-6b92-79b9-84a1-cb1d15890cb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019e0306-6b92-72c6-9336-1a3220f483cb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019e0306-6b92-72c6-9336-1a3220f483cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019e0306-6b92-7af3-a58e-32ec13e4debe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019e0306-6b92-7af3-a58e-32ec13e4debe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019e0306-6b92-7c35-b86e-63b29456c867" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019e0306-6b92-7c35-b86e-63b29456c867" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment_019e0306-6b92-74a4-9625-a03df3affab9" xlink:href="vtrs-20260630.xsd#vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment_019e0306-6b92-74a4-9625-a03df3affab9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_019e0306-6b92-7697-bb9b-7d6c1f5c9954" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e0306-6b92-76ea-b358-85ee69e48631" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_019e0306-6b92-7697-bb9b-7d6c1f5c9954" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019e0306-6b92-7cc0-bfa7-9cbb08ed4a49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_019e0306-6b92-7cc0-bfa7-9cbb08ed4a49" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_019e0306-6b92-7ac8-9c96-596b695cf616" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_019e0306-6b92-7ac8-9c96-596b695cf616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e0306-6b92-7f3f-8fca-09893c148cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019e0306-6b92-7f3f-8fca-09893c148cfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_019e0306-6b92-71ca-9d58-026fa4c4eaf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_019e0306-6b92-71ca-9d58-026fa4c4eaf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e0306-6b92-752d-95b1-ab318e58bba3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e0306-6b92-752d-95b1-ab318e58bba3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_019e0306-6b92-7d02-b9bf-96d7e1adb625" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_019e0306-6b92-7d02-b9bf-96d7e1adb625" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_019e0306-6b92-7df0-b9e8-499ce273c066" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_019e0306-6b92-7df0-b9e8-499ce273c066" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_019f676b-4544-7ba5-be58-3a6826b939c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_019f676b-4544-7ba5-be58-3a6826b939c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019f676b-4544-78ac-b24b-bf38c2615104" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_019f676b-4544-78ac-b24b-bf38c2615104" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f676b-4544-7abb-89ff-66d30467b230" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e0306-6b92-7387-a210-54c5e384ec29" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_019f676b-4544-7abb-89ff-66d30467b230" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#RevenueRecognitionandAccountsReceivableVariableConsiderationDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SalesRevenueGrosstonetadjustments_019e0306-6b92-71a2-b1c7-857378f7193a" xlink:href="vtrs-20260630.xsd#vtrs_SalesRevenueGrosstonetadjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Chargebacks_019e0306-6b92-799b-95b9-d990db5f14f4" xlink:href="vtrs-20260630.xsd#vtrs_Chargebacks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_019e0306-6b92-71a2-b1c7-857378f7193a" xlink:to="loc_vtrs_Chargebacks_019e0306-6b92-799b-95b9-d990db5f14f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AccruedSalesAllowances_019e0306-6b92-75ee-a8ba-c5c133d20e61" xlink:href="vtrs-20260630.xsd#vtrs_AccruedSalesAllowances"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_019e0306-6b92-71a2-b1c7-857378f7193a" xlink:to="loc_vtrs_AccruedSalesAllowances_019e0306-6b92-75ee-a8ba-c5c133d20e61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_RevenuefromContractwithCustomerReturns_019e0306-6b92-7bae-9d59-bd00f2c80edc" xlink:href="vtrs-20260630.xsd#vtrs_RevenuefromContractwithCustomerReturns"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_019e0306-6b92-71a2-b1c7-857378f7193a" xlink:to="loc_vtrs_RevenuefromContractwithCustomerReturns_019e0306-6b92-7bae-9d59-bd00f2c80edc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Medicaidandothergovernmentalrebates_019e0306-6b92-7a45-b7ef-fb2c89aa4e81" xlink:href="vtrs-20260630.xsd#vtrs_Medicaidandothergovernmentalrebates"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_019e0306-6b92-71a2-b1c7-857378f7193a" xlink:to="loc_vtrs_Medicaidandothergovernmentalrebates_019e0306-6b92-7a45-b7ef-fb2c89aa4e81" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e0306-6b92-7548-80fa-f1382be620ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_019e0306-6b92-7287-b2bc-196aa7807bb8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019e0306-6b92-7548-80fa-f1382be620ac" xlink:to="loc_us-gaap_ReceivablesNetCurrent_019e0306-6b92-7287-b2bc-196aa7807bb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_019e0306-6b92-7c57-9d7d-86f31712a525" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_019e0306-6b92-7548-80fa-f1382be620ac" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_019e0306-6b92-7c57-9d7d-86f31712a525" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019e0306-6b93-719d-9bc4-acab081aacdc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_019e0306-6b93-719d-9bc4-acab081aacdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_019e0306-6b93-7a78-aeb0-1b3d4b52d4ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_019e0306-6b93-7a78-aeb0-1b3d4b52d4ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodBeforeTaxAttributableToParent_019e0306-6b93-722c-bd40-28bd646e5f4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAociCurrentPeriodBeforeTaxAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodBeforeTaxAttributableToParent_019e0306-6b93-722c-bd40-28bd646e5f4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_019e0306-6b93-7b6c-b5a8-da38cfc6fcf7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_019e0306-6b93-7b6c-b5a8-da38cfc6fcf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_019e0306-6b93-7a3f-9af8-d8404d84bc4e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_019e0306-6b93-7471-85de-797aef4b8284" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_019e0306-6b93-7a3f-9af8-d8404d84bc4e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e0306-6b93-7886-a979-bd7cc6ee45be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e0306-6b93-7df1-ae3d-7c5b5e4dafcd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e0306-6b93-7886-a979-bd7cc6ee45be" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e0306-6b93-7df1-ae3d-7c5b5e4dafcd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019e0306-6b93-77bc-bdfe-cdfbc285399a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019e0306-6b93-7886-a979-bd7cc6ee45be" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_019e0306-6b93-77bc-bdfe-cdfbc285399a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e0306-6b93-7c66-a03b-0056a71c76b2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e0306-6b93-7f53-9760-12c06d853a88" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e0306-6b93-7c66-a03b-0056a71c76b2" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e0306-6b93-7f53-9760-12c06d853a88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e0306-6b93-7265-9eb4-3ca0b1366378" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e0306-6b93-7c66-a03b-0056a71c76b2" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e0306-6b93-7265-9eb4-3ca0b1366378" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e0306-6b93-747c-9a87-641b552f0708" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e0306-6b93-7c66-a03b-0056a71c76b2" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e0306-6b93-747c-9a87-641b552f0708" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_019e0306-6b93-7836-ae6d-3054b336a761" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_019e0306-6b93-7836-ae6d-3054b336a761" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019e0306-6b93-76db-946a-173374a51a4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_019e0306-6b93-76db-946a-173374a51a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019e0306-6b93-7d4c-9a48-b5809282965b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_OtherAssetsCurrent_019e0306-6b93-7d4c-9a48-b5809282965b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e0306-6b93-7598-bbf4-183e0ec957f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e0306-6b93-7598-bbf4-183e0ec957f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReceivable_019e0306-6b93-771b-b1d4-d089247ba3a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxReceivable"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_IncomeTaxReceivable_019e0306-6b93-771b-b1d4-d089247ba3a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DeferredChargesTaxOnIntercompanyProfit_019e0306-6b93-7c51-baf4-34ce739433fa" xlink:href="vtrs-20260630.xsd#vtrs_DeferredChargesTaxOnIntercompanyProfit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_vtrs_DeferredChargesTaxOnIntercompanyProfit_019e0306-6b93-7c51-baf4-34ce739433fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_019e0306-6b93-79bc-a031-3b53586112d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TradingSecurities"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e0306-6b93-71d5-b741-1711d068f59e" xlink:to="loc_us-gaap_TradingSecurities_019e0306-6b93-79bc-a031-3b53586112d3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e0306-6b93-7b36-927c-33da19ec73a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019e0306-6b93-7476-83e3-8f8625678f82" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e0306-6b93-7b36-927c-33da19ec73a2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019e0306-6b93-7476-83e3-8f8625678f82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e0306-6b93-7ad8-a533-83b90df292d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e0306-6b93-7b36-927c-33da19ec73a2" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e0306-6b93-7ad8-a533-83b90df292d6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b93-788b-a1f6-4d1d972dd95a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCost_019e0306-6b93-7a5c-aa5b-517e7b1f456c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquitySecuritiesFvNiCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b93-788b-a1f6-4d1d972dd95a" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCost_019e0306-6b93-7a5c-aa5b-517e7b1f456c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Otherlongtermassets_019e0306-6b93-7b69-b7d8-1713000f9c1b" xlink:href="vtrs-20260630.xsd#vtrs_Otherlongtermassets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b93-788b-a1f6-4d1d972dd95a" xlink:to="loc_vtrs_Otherlongtermassets_019e0306-6b93-7b69-b7d8-1713000f9c1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e0306-6b93-79ea-ae7d-3e6a92e1ad44" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_019e0306-6b93-788b-a1f6-4d1d972dd95a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019e0306-6b93-79ea-ae7d-3e6a92e1ad44" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsTradeAccountsPayableDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_019e0306-6b93-79e0-93d3-a5d32df5f245" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_019e0306-6b93-7653-b359-943226de0e7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableTradeCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_019e0306-6b93-79e0-93d3-a5d32df5f245" xlink:to="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_019e0306-6b93-7653-b359-943226de0e7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_019e0306-6b93-7f0a-ad50-21050825daa5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableOtherCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_019e0306-6b93-79e0-93d3-a5d32df5f245" xlink:to="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_019e0306-6b93-7f0a-ad50-21050825daa5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesCurrent_019e0306-6b93-79a6-8a17-7d353a4992dd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSundryLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_OtherSundryLiabilitiesCurrent_019e0306-6b93-79a6-8a17-7d353a4992dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e0306-6b93-7063-91c2-c1f5bcb24d38" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e0306-6b93-7063-91c2-c1f5bcb24d38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_019e0306-6b93-7df3-895b-23dd2479d562" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_LitigationReserveCurrent_019e0306-6b93-7df3-895b-23dd2479d562" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019e0306-6b93-7b9f-8b25-90ebab43ddcd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityCurrent_019e0306-6b93-7b9f-8b25-90ebab43ddcd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_019e0306-6b93-745f-871d-9270f63b5a75" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_RestructuringReserveCurrent_019e0306-6b93-745f-871d-9270f63b5a75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_019e0306-6b93-71de-ae0b-e6fcf883356c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestPayableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_InterestPayableCurrent_019e0306-6b93-71de-ae0b-e6fcf883356c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DerivativeLiabilitySubjectToMasterNettingArrangementBeforeOffsetCurrent_019e0306-6b93-733b-8d2e-99ff1838f00c" xlink:href="vtrs-20260630.xsd#vtrs_DerivativeLiabilitySubjectToMasterNettingArrangementBeforeOffsetCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_vtrs_DerivativeLiabilitySubjectToMasterNettingArrangementBeforeOffsetCurrent_019e0306-6b93-733b-8d2e-99ff1838f00c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e0306-6b93-7843-9ada-eba20e241603" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e0306-6b93-7843-9ada-eba20e241603" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e0306-6b93-7886-a480-87e6dc3a6a8d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesCurrent_019e0306-6b93-7f14-bfa9-fcb0e068ad58" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e0306-6b93-7886-a480-87e6dc3a6a8d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherLongtermObligationsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#BalanceSheetComponentsOtherLongtermObligationsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherLongtermObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveNoncurrent_019e0306-6b93-7acf-b260-fac85ab3e905" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_RestructuringReserveNoncurrent_019e0306-6b93-7acf-b260-fac85ab3e905" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_019e0306-6b93-74dd-81fe-a31a969751d1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilityForUncertainTaxPositionsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_LiabilityForUncertainTaxPositionsNoncurrent_019e0306-6b93-74dd-81fe-a31a969751d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019e0306-6b93-7643-936c-41d5d5b93370" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherSundryLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_OtherSundryLiabilitiesNoncurrent_019e0306-6b93-7643-936c-41d5d5b93370" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019e0306-6b93-7e95-a3f0-5760c6062138" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_019e0306-6b93-7e95-a3f0-5760c6062138" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_019e0306-6b93-7794-b901-48e3de81a1a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_DefinedBenefitPensionPlanLiabilitiesNoncurrent_019e0306-6b93-7794-b901-48e3de81a1a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e0306-6b93-71e4-81b3-bb0a806342c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent_019e0306-6b93-77bb-9674-7af9ad92e68e" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e0306-6b93-71e4-81b3-bb0a806342c2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LossEarningsperShareBasicandDilutedEarningsPerOrdinaryShareDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#LossEarningsperShareBasicandDilutedEarningsPerOrdinaryShareDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/LossEarningsperShareBasicandDilutedEarningsPerOrdinaryShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e0306-6c3c-7c20-8c7f-32b9a8df697a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e0306-6c3c-7ea8-80e7-a2c988b58249" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e0306-6c3c-7c20-8c7f-32b9a8df697a" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019e0306-6c3c-7ea8-80e7-a2c988b58249" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e0306-6c3c-7939-b030-a2c3ecb697bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019e0306-6c3c-7c20-8c7f-32b9a8df697a" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019e0306-6c3c-7939-b030-a2c3ecb697bf" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e0306-6c3c-7b51-b738-5bf5b4dac308" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019e0306-6c3c-7031-a290-71b68b15f1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e0306-6c3c-7b51-b738-5bf5b4dac308" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019e0306-6c3c-7031-a290-71b68b15f1ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e0306-6c3c-7023-8755-fb8919cc59b9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019e0306-6c3c-7b51-b738-5bf5b4dac308" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e0306-6c3c-7023-8755-fb8919cc59b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019e0306-6c3c-7247-8b8b-528354f8cd83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e0306-6c3c-773f-8e0b-3e167667e6ea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019e0306-6c3c-7247-8b8b-528354f8cd83" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e0306-6c3c-773f-8e0b-3e167667e6ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019e0306-6c3c-7310-a66d-893c9b47686a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_019e0306-6c3c-7247-8b8b-528354f8cd83" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_019e0306-6c3c-7310-a66d-893c9b47686a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e0306-6c3c-7bcd-8f22-4813cd87c863" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e0306-6c3c-78fb-870a-e8deb82fbe33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e0306-6c3c-7bcd-8f22-4813cd87c863" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019e0306-6c3c-78fb-870a-e8deb82fbe33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e0306-6c3c-7171-80e7-4b2aa8392c5e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019e0306-6c3c-7bcd-8f22-4813cd87c863" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019e0306-6c3c-7171-80e7-4b2aa8392c5e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsAmortizationExpenseDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#GoodwillandIntangibleAssetsAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentForAmortization_019e0306-6c3c-74a8-9aed-429c82725765" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentForAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_019f6770-9be9-7b04-9375-cbd9f11ba229" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_019e0306-6c3c-74a8-9aed-429c82725765" xlink:to="loc_us-gaap_AssetImpairmentCharges_019f6770-9be9-7b04-9375-cbd9f11ba229" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_019f6770-9be9-7014-833b-b123bd4d5659" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_019e0306-6c3c-74a8-9aed-429c82725765" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_019f6770-9be9-7014-833b-b123bd4d5659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019e0306-6c3c-77c6-bf06-5ed0db0f26db" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_019e0306-6c3c-74a8-9aed-429c82725765" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019e0306-6c3c-77c6-bf06-5ed0db0f26db" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="simple" xlink:href="vtrs-20260630.xsd#DebtMinimumRepaymentsonOutstandingBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e0306-6c3d-7734-942f-b07d59950bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e0306-6c3d-7734-942f-b07d59950bd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e0306-6c3d-7df4-9805-9a1fd4d3f4ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e0306-6c3d-7df4-9805-9a1fd4d3f4ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019e0306-6c3d-7fda-a608-b16ffcf6620a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019e0306-6c3d-7fda-a608-b16ffcf6620a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019e0306-6c3d-7c5c-83e8-a219df3b6294" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019e0306-6c3d-7c5c-83e8-a219df3b6294" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_019e0306-6c3d-7bec-bd5a-10dc58bcc08c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_019e0306-6c3d-7bec-bd5a-10dc58bcc08c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_019e0306-6c3d-768c-807c-170474d4e14c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_019e0306-6c3d-7afb-a2c4-4d24a3a4b761" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_019e0306-6c3d-768c-807c-170474d4e14c" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
