<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:be534b3a-986f-4bd1-9c3d-90f7058b47aa,g:1af62799-44fb-48a7-a58a-8bc234a11d7d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="simple" xlink:href="vtrs-20240930.xsd#CondensedConsolidatedStatementsOfOperations"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f6994f1b-2545-419f-8810-946b354439db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ec64f39a-3474-4c92-85d7-4fae4343634b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f6994f1b-2545-419f-8810-946b354439db" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ec64f39a-3474-4c92-85d7-4fae4343634b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_fb843295-a135-4b3f-af94-2263cae75910" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_f6994f1b-2545-419f-8810-946b354439db" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_fb843295-a135-4b3f-af94-2263cae75910" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ce248ed9-f0b9-4dcd-ac65-6e719019d014" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_905a1e8f-9a0f-4fca-b1bf-390d3df8b5e6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ce248ed9-f0b9-4dcd-ac65-6e719019d014" xlink:to="loc_us-gaap_GrossProfit_905a1e8f-9a0f-4fca-b1bf-390d3df8b5e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_d3916890-0ff0-4bdf-b195-03ab36081c42" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ce248ed9-f0b9-4dcd-ac65-6e719019d014" xlink:to="loc_us-gaap_OperatingExpenses_d3916890-0ff0-4bdf-b195-03ab36081c42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_3d443090-3d9d-4b18-89ec-ed2edc81c6f6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_3aedd74f-e295-4814-9720-bac24dd8606a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_3d443090-3d9d-4b18-89ec-ed2edc81c6f6" xlink:to="loc_us-gaap_Revenues_3aedd74f-e295-4814-9720-bac24dd8606a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_a0992160-8678-46a3-ae31-26cf33cf77ee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_3d443090-3d9d-4b18-89ec-ed2edc81c6f6" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_a0992160-8678-46a3-ae31-26cf33cf77ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4c45aed-058c-4227-8e72-b3ac5b0ac516" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_43167bb7-ac88-49ff-82f6-c13789621fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4c45aed-058c-4227-8e72-b3ac5b0ac516" xlink:to="loc_us-gaap_OperatingIncomeLoss_43167bb7-ac88-49ff-82f6-c13789621fd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_bf0535b5-4556-4fca-8a01-0c5e12801283" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4c45aed-058c-4227-8e72-b3ac5b0ac516" xlink:to="loc_us-gaap_InterestExpense_bf0535b5-4556-4fca-8a01-0c5e12801283" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_efebc553-0c8d-47f9-9e84-5098145eb687" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c4c45aed-058c-4227-8e72-b3ac5b0ac516" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_efebc553-0c8d-47f9-9e84-5098145eb687" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_f53c2637-cc75-4db1-9ef4-0648bad096f3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_441b1d3c-3e74-4b7d-b9d8-5f9c375c6016" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f53c2637-cc75-4db1-9ef4-0648bad096f3" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_441b1d3c-3e74-4b7d-b9d8-5f9c375c6016" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6303b12b-9d5c-4cc2-979a-45ae28801de7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f53c2637-cc75-4db1-9ef4-0648bad096f3" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6303b12b-9d5c-4cc2-979a-45ae28801de7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_40d4fd8c-26aa-4a52-a6cd-b765504997c5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f53c2637-cc75-4db1-9ef4-0648bad096f3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_40d4fd8c-26aa-4a52-a6cd-b765504997c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherResearchAndDevelopmentExpenseRefund_75bd1905-e67f-445b-9791-41a12cd023ce" xlink:href="vtrs-20240930.xsd#vtrs_OtherResearchAndDevelopmentExpenseRefund"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f53c2637-cc75-4db1-9ef4-0648bad096f3" xlink:to="loc_vtrs_OtherResearchAndDevelopmentExpenseRefund_75bd1905-e67f-445b-9791-41a12cd023ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_6d894cd0-9a40-4ec3-9be7-17f0b15b025a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_cb7cc5d1-7300-467a-b2ec-ee0b16bd393d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_6d894cd0-9a40-4ec3-9be7-17f0b15b025a" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_cb7cc5d1-7300-467a-b2ec-ee0b16bd393d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2b358252-b870-427a-a686-630768f59ef4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_6d894cd0-9a40-4ec3-9be7-17f0b15b025a" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2b358252-b870-427a-a686-630768f59ef4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfComprehensiveEarningsLoss" xlink:type="simple" xlink:href="vtrs-20240930.xsd#CondensedConsolidatedStatementsOfComprehensiveEarningsLoss"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfComprehensiveEarningsLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_8e0548fc-e8c1-41ac-850f-0a8f76f5958f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_0b7851ca-0ab5-400d-9329-dce1f4281d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_8e0548fc-e8c1-41ac-850f-0a8f76f5958f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_0b7851ca-0ab5-400d-9329-dce1f4281d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_1a0b155e-e6af-4a35-90da-5fa63987cde2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_8e0548fc-e8c1-41ac-850f-0a8f76f5958f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_1a0b155e-e6af-4a35-90da-5fa63987cde2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_99e36ec1-5940-4a15-a3a7-9485de8a3aea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_124e950d-64ac-43b7-9190-ea6fbb6c9b01" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_99e36ec1-5940-4a15-a3a7-9485de8a3aea" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationBeforeTax_124e950d-64ac-43b7-9190-ea6fbb6c9b01" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_e99486f4-a227-4a54-a2b6-c38bf6a769d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_99e36ec1-5940-4a15-a3a7-9485de8a3aea" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentBeforeTax_e99486f4-a227-4a54-a2b6-c38bf6a769d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_d20d74a7-6fc1-4095-bbc5-64a04bfc3576" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_99e36ec1-5940-4a15-a3a7-9485de8a3aea" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_d20d74a7-6fc1-4095-bbc5-64a04bfc3576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_7ea4943b-6583-47c1-a95d-ef6457e5bc5a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTaxPortionAttributableToParent_99e36ec1-5940-4a15-a3a7-9485de8a3aea" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_7ea4943b-6583-47c1-a95d-ef6457e5bc5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_1c5cf4fc-823f-432c-8281-eaee4e16fd35" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_8d328f61-ec0d-47d9-bbce-d491cd29c6f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_1c5cf4fc-823f-432c-8281-eaee4e16fd35" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_8d328f61-ec0d-47d9-bbce-d491cd29c6f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_cd60227a-4c2e-4a3f-b861-b88738795e60" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_1c5cf4fc-823f-432c-8281-eaee4e16fd35" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_cd60227a-4c2e-4a3f-b861-b88738795e60" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="vtrs-20240930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3f470e10-1793-4e17-bd49-d5ec3a80d238" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_c790c010-1dba-4d71-b3d4-e05a50a2a0d7" xlink:href="vtrs-20240930.xsd#vtrs_StockholdersEquityParentBeforeTreasuryStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3f470e10-1793-4e17-bd49-d5ec3a80d238" xlink:to="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_c790c010-1dba-4d71-b3d4-e05a50a2a0d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValue_3f0aa5a2-45d8-4ab7-b282-24d7142b821e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TreasuryStockValue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_3f470e10-1793-4e17-bd49-d5ec3a80d238" xlink:to="loc_us-gaap_TreasuryStockValue_3f0aa5a2-45d8-4ab7-b282-24d7142b821e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_2cf8ea0b-a413-49e2-beaa-f3a6bf1dd06c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_2cf8ea0b-a413-49e2-beaa-f3a6bf1dd06c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_1b36b08d-6fce-402a-a3f1-cf7c42bc6fa5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_1b36b08d-6fce-402a-a3f1-cf7c42bc6fa5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_cfa44e4b-c576-4c24-8232-3cf9f871b4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:to="loc_us-gaap_LongTermDebtCurrent_cfa44e4b-c576-4c24-8232-3cf9f871b4a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_00f03228-39dc-432e-ba61-9e4a7db61fcf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:to="loc_us-gaap_LiabilitiesOfDisposalGroupIncludingDiscontinuedOperation_00f03228-39dc-432e-ba61-9e4a7db61fcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_70645c25-0264-42f3-a903-d52fe18dbaa3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f37e2f2c-4b63-4051-aaed-1079d3fc3941" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_70645c25-0264-42f3-a903-d52fe18dbaa3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_c37b1d0d-5347-4a44-974a-7f7337c28b64" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_AssetsCurrent_c37b1d0d-5347-4a44-974a-7f7337c28b64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_1afa84ab-727b-4289-97df-27c42651fa82" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_1afa84ab-727b-4289-97df-27c42651fa82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_cf75d8da-942f-426f-8302-0a06193a8310" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_cf75d8da-942f-426f-8302-0a06193a8310" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_bbbc37a2-6389-4121-a036-d0b67d00bd7c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_Goodwill_bbbc37a2-6389-4121-a036-d0b67d00bd7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_70f66128-d732-4166-a76b-53f6af7bd33d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_70f66128-d732-4166-a76b-53f6af7bd33d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_2bf9c6c3-7807-4891-bc0f-45fab99cc1c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_c51d6843-19de-4965-8869-0ae2f53d9356" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_2bf9c6c3-7807-4891-bc0f-45fab99cc1c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_660a2c05-0ffe-4919-8760-69e29e1ec007" xlink:href="vtrs-20240930.xsd#vtrs_StockholdersEquityParentBeforeTreasuryStock"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_92dec1f2-5569-4d2d-be99-abfa0e9ddf14" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_660a2c05-0ffe-4919-8760-69e29e1ec007" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_92dec1f2-5569-4d2d-be99-abfa0e9ddf14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_4fc1e03e-31fc-4686-a7a3-76d91ab2743c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_660a2c05-0ffe-4919-8760-69e29e1ec007" xlink:to="loc_us-gaap_CommonStockValue_4fc1e03e-31fc-4686-a7a3-76d91ab2743c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2a5f04fb-d7fd-4300-bb67-d411ef7d0bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_660a2c05-0ffe-4919-8760-69e29e1ec007" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2a5f04fb-d7fd-4300-bb67-d411ef7d0bd9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_ebc29810-e9cf-4374-8f21-d700c8103d05" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_StockholdersEquityParentBeforeTreasuryStock_660a2c05-0ffe-4919-8760-69e29e1ec007" xlink:to="loc_us-gaap_AdditionalPaidInCapital_ebc29810-e9cf-4374-8f21-d700c8103d05" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation_715b034a-33cf-4714-be7e-20ba38f6b2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperation_715b034a-33cf-4714-be7e-20ba38f6b2e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f67032b1-c6b9-4c50-8620-7585a877de64" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f67032b1-c6b9-4c50-8620-7585a877de64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_080c2062-4a44-4756-b41d-062f42d8449e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:to="loc_us-gaap_InventoryNet_080c2062-4a44-4756-b41d-062f42d8449e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_52ac01a0-7a25-4b24-b89d-f315bd6f7315" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_52ac01a0-7a25-4b24-b89d-f315bd6f7315" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a0c2122b-b088-4f02-a783-2e84b58db2e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_e2020891-b8ac-42c2-aa14-e20d07316c18" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a0c2122b-b088-4f02-a783-2e84b58db2e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_039e134e-bf8c-4f4b-b25e-b419e15a929f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_82621cb5-1893-425e-9793-7f0b2518222e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_039e134e-bf8c-4f4b-b25e-b419e15a929f" xlink:to="loc_us-gaap_LiabilitiesCurrent_82621cb5-1893-425e-9793-7f0b2518222e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_79d7190a-6017-466b-9391-ed6d6f954801" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_039e134e-bf8c-4f4b-b25e-b419e15a929f" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_79d7190a-6017-466b-9391-ed6d6f954801" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_c5350469-f3a2-47f8-8a7a-6a9c8c21ad0d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_039e134e-bf8c-4f4b-b25e-b419e15a929f" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_c5350469-f3a2-47f8-8a7a-6a9c8c21ad0d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_9e4d54b3-dfb6-47cd-b78d-1e0066dcdca4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_039e134e-bf8c-4f4b-b25e-b419e15a929f" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_9e4d54b3-dfb6-47cd-b78d-1e0066dcdca4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_ab04798f-b3c0-4dc5-859f-90a88afb8579" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_85186dd8-9049-4317-99e0-e7110ee46534" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_ab04798f-b3c0-4dc5-859f-90a88afb8579" xlink:to="loc_us-gaap_Liabilities_85186dd8-9049-4317-99e0-e7110ee46534" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_b2208220-9b5b-469e-90e7-2beb61f6dec9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_ab04798f-b3c0-4dc5-859f-90a88afb8579" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_b2208220-9b5b-469e-90e7-2beb61f6dec9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/CondensedConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="vtrs-20240930.xsd#CondensedConsolidatedStatementsOfCashFlows"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/CondensedConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d860e455-e8ee-44f1-8f11-9c86a544e878" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_7dc1c21a-baee-4ed3-bfac-74e9b685d865" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d860e455-e8ee-44f1-8f11-9c86a544e878" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_7dc1c21a-baee-4ed3-bfac-74e9b685d865" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acfdaf59-1e19-491e-a218-968a343a0034" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d860e455-e8ee-44f1-8f11-9c86a544e878" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_acfdaf59-1e19-491e-a218-968a343a0034" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b83a001d-9022-4d80-b8da-4b404f393e73" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d860e455-e8ee-44f1-8f11-9c86a544e878" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b83a001d-9022-4d80-b8da-4b404f393e73" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c762baa7-e982-4f19-ae98-34a381a0dce4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d860e455-e8ee-44f1-8f11-9c86a544e878" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c762baa7-e982-4f19-ae98-34a381a0dce4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_001f5992-bc28-4d8b-b1c1-1f9af74bae48" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_001f5992-bc28-4d8b-b1c1-1f9af74bae48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_b7f40fd5-ea6e-4ffe-a8af-222d14553cbf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_b7f40fd5-ea6e-4ffe-a8af-222d14553cbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_368b6a82-e1b0-4913-8286-d37e5e4ec3e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_368b6a82-e1b0-4913-8286-d37e5e4ec3e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_1676573e-410e-447a-8121-32684fc9c6fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_1676573e-410e-447a-8121-32684fc9c6fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_11951757-74f6-41b1-9231-b3f9532ec9d4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_11951757-74f6-41b1-9231-b3f9532ec9d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment_f8890bac-7cf0-4092-9458-5b9fdcf1f03f" xlink:href="vtrs-20240930.xsd#vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_vtrs_ProceedsFromRefundOfInProcessResearchAndDevelopment_f8890bac-7cf0-4092-9458-5b9fdcf1f03f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_ea6a41a2-2c00-4821-bd06-3156bacb08d8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_ea6a41a2-2c00-4821-bd06-3156bacb08d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_1c0cbeb8-2697-41c8-bc99-0d9004b3fe36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromSaleOfProductiveAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_5207b699-64f8-4d1f-9ba1-deab55853c80" xlink:to="loc_us-gaap_ProceedsFromSaleOfProductiveAssets_1c0cbeb8-2697-41c8-bc99-0d9004b3fe36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_3e654f6d-b115-4357-b54b-0108eb182eb7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_3e654f6d-b115-4357-b54b-0108eb182eb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_de67ae91-cab8-4ab1-9d32-01a366461a5e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_de67ae91-cab8-4ab1-9d32-01a366461a5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d0609d48-a09c-4bf0-be21-442edb39f0e4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_d0609d48-a09c-4bf0-be21-442edb39f0e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_58f9880f-f96f-4080-a7d5-a42747452f50" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_58f9880f-f96f-4080-a7d5-a42747452f50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_da3bef95-c46b-4350-836b-2e94ee0f4182" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_da3bef95-c46b-4350-836b-2e94ee0f4182" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_f151ed77-c50b-469b-8cbe-1104b78d9dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_f151ed77-c50b-469b-8cbe-1104b78d9dfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_13e97973-ba1e-402c-a702-871ee7e0f20b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_13e97973-ba1e-402c-a702-871ee7e0f20b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_b8e8562e-5d3e-4288-b879-d554dd09e50d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_b8e8562e-5d3e-4288-b879-d554dd09e50d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_42f7c0b9-4466-4910-b67a-f5bc83a94948" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_42f7c0b9-4466-4910-b67a-f5bc83a94948" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PaymentsToAcquireIntangibleAssetsFinancingActivity_64e396fc-0632-4edb-8ef8-c1ddf27ea2f3" xlink:href="vtrs-20240930.xsd#vtrs_PaymentsToAcquireIntangibleAssetsFinancingActivity"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_554aa9bd-a063-44dd-9acf-d161bfe209aa" xlink:to="loc_vtrs_PaymentsToAcquireIntangibleAssetsFinancingActivity_64e396fc-0632-4edb-8ef8-c1ddf27ea2f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_69f63ca3-28af-4ef3-bfbb-711ca76929ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_69f63ca3-28af-4ef3-bfbb-711ca76929ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_4ddcf950-bcef-41a2-a490-713473c9f781" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_4ddcf950-bcef-41a2-a490-713473c9f781" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_248d88ff-4756-4615-9950-2b0f111ce0aa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_ShareBasedCompensation_248d88ff-4756-4615-9950-2b0f111ce0aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_7c32e2bf-3e06-4182-b200-5bf4f40d597c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_7c32e2bf-3e06-4182-b200-5bf4f40d597c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_a5487edf-d122-492b-a8a3-24ae1b753522" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_a5487edf-d122-492b-a8a3-24ae1b753522" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther_b5636c00-d354-4db7-8867-6f12f347210a" xlink:href="vtrs-20240930.xsd#vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_vtrs_PaymentsToAcquireInProcessResearchAndDevelopmentOther_b5636c00-d354-4db7-8867-6f12f347210a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_a4c89139-c0aa-4af7-82e1-1ffdaef1814a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_a4c89139-c0aa-4af7-82e1-1ffdaef1814a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Changeinnoncashlitigationsettlementsnet_4d4c7f18-ef66-4d72-9a39-8564b98493c6" xlink:href="vtrs-20240930.xsd#vtrs_Changeinnoncashlitigationsettlementsnet"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_vtrs_Changeinnoncashlitigationsettlementsnet_4d4c7f18-ef66-4d72-9a39-8564b98493c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3a5ebafc-b400-4c3d-b6c4-82d81fc32cba" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3a5ebafc-b400-4c3d-b6c4-82d81fc32cba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_8aeff375-44c9-499e-9b85-f1f8b0eeb3a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_8aeff375-44c9-499e-9b85-f1f8b0eeb3a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_80dbedd9-ea06-4850-8c4b-17c9a6dfdaf4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_80dbedd9-ea06-4850-8c4b-17c9a6dfdaf4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_b317f9cc-41ea-4868-8124-95ae46373706" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_b317f9cc-41ea-4868-8124-95ae46373706" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_91030d08-148f-4770-83bb-27e7874aa465" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_842fe313-bf2f-43db-9dc8-408c020f2344" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_91030d08-148f-4770-83bb-27e7874aa465" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#RevenueRecognitionandAccountsReceivableVariableConsiderationDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SalesRevenueGrosstonetadjustments_18b4a1e3-cbf4-4ad1-8d79-35172b3c8747" xlink:href="vtrs-20240930.xsd#vtrs_SalesRevenueGrosstonetadjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Chargebacks_3fca14b5-aaba-4027-bb34-e70d071f20e4" xlink:href="vtrs-20240930.xsd#vtrs_Chargebacks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_18b4a1e3-cbf4-4ad1-8d79-35172b3c8747" xlink:to="loc_vtrs_Chargebacks_3fca14b5-aaba-4027-bb34-e70d071f20e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AccruedSalesAllowances_f89de258-cb63-4989-ad2d-20ae1056788c" xlink:href="vtrs-20240930.xsd#vtrs_AccruedSalesAllowances"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_18b4a1e3-cbf4-4ad1-8d79-35172b3c8747" xlink:to="loc_vtrs_AccruedSalesAllowances_f89de258-cb63-4989-ad2d-20ae1056788c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_RevenuefromContractwithCustomerReturns_53829d45-b445-4a00-9f22-e01ecd7d5aa8" xlink:href="vtrs-20240930.xsd#vtrs_RevenuefromContractwithCustomerReturns"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_18b4a1e3-cbf4-4ad1-8d79-35172b3c8747" xlink:to="loc_vtrs_RevenuefromContractwithCustomerReturns_53829d45-b445-4a00-9f22-e01ecd7d5aa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Medicaidandothergovernmentalrebates_e0b977c0-fb92-467b-b90d-f0d8b8a32229" xlink:href="vtrs-20240930.xsd#vtrs_Medicaidandothergovernmentalrebates"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_18b4a1e3-cbf4-4ad1-8d79-35172b3c8747" xlink:to="loc_vtrs_Medicaidandothergovernmentalrebates_e0b977c0-fb92-467b-b90d-f0d8b8a32229" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_07e280df-1fdb-4653-854e-eb21ee1a5bde" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_437817f5-8046-49a2-8cba-01ad87d188fb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_07e280df-1fdb-4653-854e-eb21ee1a5bde" xlink:to="loc_us-gaap_ReceivablesNetCurrent_437817f5-8046-49a2-8cba-01ad87d188fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_aae52296-3da2-4121-8095-8dfc1a5e1e02" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_07e280df-1fdb-4653-854e-eb21ee1a5bde" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_aae52296-3da2-4121-8095-8dfc1a5e1e02" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/AcquisitionsandOtherTransactionsPurchasePriceAllocationsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#AcquisitionsandOtherTransactionsPurchasePriceAllocationsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/AcquisitionsandOtherTransactionsPurchasePriceAllocationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3f01b3d9-0338-408e-953c-ad2f3df106c4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInProcessResearchAndDevelopment_b3712c27-4c45-467e-9d04-bea58c11390a" xlink:href="vtrs-20240930.xsd#vtrs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInProcessResearchAndDevelopment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3f01b3d9-0338-408e-953c-ad2f3df106c4" xlink:to="loc_vtrs_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInProcessResearchAndDevelopment_b3712c27-4c45-467e-9d04-bea58c11390a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_cfa1dc4b-46e5-4847-a74a-f723475bcc8f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3f01b3d9-0338-408e-953c-ad2f3df106c4" xlink:to="loc_us-gaap_Goodwill_cfa1dc4b-46e5-4847-a74a-f723475bcc8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_3143ea45-d46a-43b1-99be-bddb2c5de43b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_3f01b3d9-0338-408e-953c-ad2f3df106c4" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_3143ea45-d46a-43b1-99be-bddb2c5de43b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f7eb2dfd-69e2-4e18-b7d6-1a562f682e07" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_f6273256-084f-4b67-8d5e-c70f98f33970" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f7eb2dfd-69e2-4e18-b7d6-1a562f682e07" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_f6273256-084f-4b67-8d5e-c70f98f33970" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_f2c01e43-bde8-404f-8efa-c9baf3ebeb8b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_f7eb2dfd-69e2-4e18-b7d6-1a562f682e07" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_f2c01e43-bde8-404f-8efa-c9baf3ebeb8b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/PensionsandOtherPostretirementBenefitsNetPeriodicBenefitCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_841db153-bc69-4c39-bdea-9e4136b4ae46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_841db153-bc69-4c39-bdea-9e4136b4ae46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_be877f1f-640c-409c-b6b1-1d59ade2872e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_be877f1f-640c-409c-b6b1-1d59ade2872e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_816caea6-8792-4484-916c-447515dfc66b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_816caea6-8792-4484-916c-447515dfc66b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanOtherCosts_6f5ba07a-b110-4f5f-a896-90072983039d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanOtherCosts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_DefinedBenefitPlanOtherCosts_6f5ba07a-b110-4f5f-a896-90072983039d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_9b01e57e-e2c2-40ae-8fd1-bc96b638e9d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_9b01e57e-e2c2-40ae-8fd1-bc96b638e9d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_5da8487f-3d1d-482c-97b0-32026df99269" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_df343e36-171b-466e-8ac8-890016821a61" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_5da8487f-3d1d-482c-97b0-32026df99269" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsCashcashequivalentsandrestrictedcashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_47a0b88d-4a87-46d6-b9f6-5909a58535db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_933983ec-dbbe-4c5f-8447-f33296e110d3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_47a0b88d-4a87-46d6-b9f6-5909a58535db" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_933983ec-dbbe-4c5f-8447-f33296e110d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_60bbd4b5-5154-4442-8d92-9c3d261fdd3d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_47a0b88d-4a87-46d6-b9f6-5909a58535db" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_60bbd4b5-5154-4442-8d92-9c3d261fdd3d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_d53e5e2a-5833-40df-a875-a89f029b857e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_6f87dcad-cd91-4777-8e2e-feee0c25de4c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_d53e5e2a-5833-40df-a875-a89f029b857e" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_6f87dcad-cd91-4777-8e2e-feee0c25de4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1b265d86-114c-4b84-94c7-6599517fe7f4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_d53e5e2a-5833-40df-a875-a89f029b857e" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1b265d86-114c-4b84-94c7-6599517fe7f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_55de5d4e-86da-4935-842b-67e38bafc05c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_d53e5e2a-5833-40df-a875-a89f029b857e" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_55de5d4e-86da-4935-842b-67e38bafc05c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPrepaidExpensesandOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_b999a582-e94f-4d35-b436-233233319bde" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_b999a582-e94f-4d35-b436-233233319bde" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a3cca621-339f-4990-9f43-585968ec87bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_a3cca621-339f-4990-9f43-585968ec87bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_e1bde036-c71a-45c1-a797-bed683639422" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_e1bde036-c71a-45c1-a797-bed683639422" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradingSecurities_abee6caf-ad34-4549-a90d-c3c3aed2c2b3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TradingSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:to="loc_us-gaap_TradingSecurities_abee6caf-ad34-4549-a90d-c3c3aed2c2b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_74e3a1ae-effa-4fac-9639-c1e657f2efd0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_be35e654-b060-4e8e-95d4-35ea2cc861e1" xlink:to="loc_us-gaap_OtherAssetsCurrent_74e3a1ae-effa-4fac-9639-c1e657f2efd0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_bc9b6648-7892-436d-9eff-16051149b2bc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_faba4ba7-5f61-4c80-8685-e375538b8d79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_bc9b6648-7892-436d-9eff-16051149b2bc" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_faba4ba7-5f61-4c80-8685-e375538b8d79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_57df2250-5083-4132-a022-328745588582" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_bc9b6648-7892-436d-9eff-16051149b2bc" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_57df2250-5083-4132-a022-328745588582" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_6a50dbca-dff9-4a5f-a462-9c9d8cecbebe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_8a6730bd-039f-457a-8bd4-b83f09f9217e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_6a50dbca-dff9-4a5f-a462-9c9d8cecbebe" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_8a6730bd-039f-457a-8bd4-b83f09f9217e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Otherlongtermassets_94a07ca1-c89b-494d-a856-c6016f9329eb" xlink:href="vtrs-20240930.xsd#vtrs_Otherlongtermassets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_6a50dbca-dff9-4a5f-a462-9c9d8cecbebe" xlink:to="loc_vtrs_Otherlongtermassets_94a07ca1-c89b-494d-a856-c6016f9329eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCost_10c17bac-4d5e-4105-b614-e21454a4eb1c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquitySecuritiesFvNiCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_6a50dbca-dff9-4a5f-a462-9c9d8cecbebe" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCost_10c17bac-4d5e-4105-b614-e21454a4eb1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationDeferredConsiderationDue_a85888b0-481e-41e2-bf45-0d46e68ce1b8" xlink:href="vtrs-20240930.xsd#vtrs_DisposalGroupIncludingDiscontinuedOperationDeferredConsiderationDue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_6a50dbca-dff9-4a5f-a462-9c9d8cecbebe" xlink:to="loc_vtrs_DisposalGroupIncludingDiscontinuedOperationDeferredConsiderationDue_a85888b0-481e-41e2-bf45-0d46e68ce1b8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#BalanceSheetComponentsTradeAccountsPayableDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_3d27b66a-42c5-4fb4-9736-3ef668c86903" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_42ad4fa6-2370-40c6-9bce-efd3b6dad0b9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableTradeCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_3d27b66a-42c5-4fb4-9736-3ef668c86903" xlink:to="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_42ad4fa6-2370-40c6-9bce-efd3b6dad0b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_e60deda8-1139-40a5-8a4a-dec6ab843667" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccountsPayableOtherCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_3d27b66a-42c5-4fb4-9736-3ef668c86903" xlink:to="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_e60deda8-1139-40a5-8a4a-dec6ab843667" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EarningsLossperOrdinaryShareBasicandDilutedEarningsPerOrdinaryShareDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#EarningsLossperOrdinaryShareBasicandDilutedEarningsPerOrdinaryShareDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EarningsLossperOrdinaryShareBasicandDilutedEarningsPerOrdinaryShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7efd1d9c-8d8e-4583-a50f-abadee16c2d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_193138b8-7e5e-44ce-b93e-c6addbb89995" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7efd1d9c-8d8e-4583-a50f-abadee16c2d6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_193138b8-7e5e-44ce-b93e-c6addbb89995" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6a87e627-52b1-448f-8c80-f459a215a382" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7efd1d9c-8d8e-4583-a50f-abadee16c2d6" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_6a87e627-52b1-448f-8c80-f459a215a382" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_aa207369-e5f8-4cec-b499-e4b35ae143eb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_b1e6235d-6562-405c-b54e-43ee64830803" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_aa207369-e5f8-4cec-b499-e4b35ae143eb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_b1e6235d-6562-405c-b54e-43ee64830803" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_f083884c-f2e2-4d96-b20a-f7e62c37c397" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_aa207369-e5f8-4cec-b499-e4b35ae143eb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_f083884c-f2e2-4d96-b20a-f7e62c37c397" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_100bee54-b685-4165-bdbb-12850535d07c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b321683-9e9f-41ce-a2c4-33102566b77e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_100bee54-b685-4165-bdbb-12850535d07c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b321683-9e9f-41ce-a2c4-33102566b77e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_000d75a6-e0bc-400b-b02e-6adf97364c2d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_100bee54-b685-4165-bdbb-12850535d07c" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_000d75a6-e0bc-400b-b02e-6adf97364c2d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a0815a25-a9cb-4a3a-b7cb-dfb134bfa738" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_22284738-6b6f-42d3-a1ac-fd6e5a4bb0fa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a0815a25-a9cb-4a3a-b7cb-dfb134bfa738" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_22284738-6b6f-42d3-a1ac-fd6e5a4bb0fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_dac68108-2ca8-44ad-a1f0-54417d4293fd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a0815a25-a9cb-4a3a-b7cb-dfb134bfa738" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_dac68108-2ca8-44ad-a1f0-54417d4293fd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandIntangibleAssetsAmortizationExpenseDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#GoodwillandIntangibleAssetsAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/GoodwillandIntangibleAssetsAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentForAmortization_fc5d058d-d8c1-4a8e-a6ec-fdeab3dce8ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdjustmentForAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_6046ec0e-e8f0-4c2a-9752-2d9e880c879a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_fc5d058d-d8c1-4a8e-a6ec-fdeab3dce8ae" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsIndefinitelivedExcludingGoodwill_6046ec0e-e8f0-4c2a-9752-2d9e880c879a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_985b0d2c-56c7-42f9-a728-9858182cd37c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_fc5d058d-d8c1-4a8e-a6ec-fdeab3dce8ae" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_985b0d2c-56c7-42f9-a728-9858182cd37c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_c176760d-ea48-449e-8d94-53cdbbcf25f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentForAmortization_fc5d058d-d8c1-4a8e-a6ec-fdeab3dce8ae" xlink:to="loc_us-gaap_AssetImpairmentCharges_c176760d-ea48-449e-8d94-53cdbbcf25f9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="simple" xlink:href="vtrs-20240930.xsd#DebtMinimumRepaymentsonOutstandingBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_68ee80a6-55bb-40cc-b0a5-55309d856c4c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_68ee80a6-55bb-40cc-b0a5-55309d856c4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f20b25c6-4030-4cf6-963e-fa76df663f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f20b25c6-4030-4cf6-963e-fa76df663f9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_2130ce1c-c11c-4c07-a970-9f3e78885c71" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_2130ce1c-c11c-4c07-a970-9f3e78885c71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_117985ad-b419-484d-83fc-5d2521bf6210" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_117985ad-b419-484d-83fc-5d2521bf6210" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_ffa31889-2cb7-485e-9797-e9ebf1d9622f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_ffa31889-2cb7-485e-9797-e9ebf1d9622f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_16b562e8-67be-4bcd-8661-08ee86d3fdd8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_b4ff067c-5aae-46ff-b6ed-df3cdec41dc2" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_16b562e8-67be-4bcd-8661-08ee86d3fdd8" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
