<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:7d588a56-150d-4ea9-a97c-5b39f92c59e0,g:83cb92d0-838c-40d0-a420-8487c2f4fc1b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.viatris.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="vtrs-20211231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5ab7520d-dcc8-4e60-a192-57f5efd9c7da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_73b05fa2-10b8-4fbc-8cef-8b937280ceb2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5ab7520d-dcc8-4e60-a192-57f5efd9c7da" xlink:to="loc_us-gaap_AdditionalPaidInCapital_73b05fa2-10b8-4fbc-8cef-8b937280ceb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_1209926d-2b43-4085-b82f-ff216b265b0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5ab7520d-dcc8-4e60-a192-57f5efd9c7da" xlink:to="loc_us-gaap_CommonStockValue_1209926d-2b43-4085-b82f-ff216b265b0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_ff7c6e64-9807-4095-8ca1-197ad0016ca7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5ab7520d-dcc8-4e60-a192-57f5efd9c7da" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_ff7c6e64-9807-4095-8ca1-197ad0016ca7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_79324935-7f69-42c1-99be-0ed3419a4652" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_5ab7520d-dcc8-4e60-a192-57f5efd9c7da" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_79324935-7f69-42c1-99be-0ed3419a4652" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_166b6d95-3e72-4c2f-8fd0-892558383fc0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2e76a3d1-6a10-4fe8-a84b-c9e366ada551" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_166b6d95-3e72-4c2f-8fd0-892558383fc0" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_2e76a3d1-6a10-4fe8-a84b-c9e366ada551" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_e5f72572-465e-46f0-b37d-32f2a62a12b8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_166b6d95-3e72-4c2f-8fd0-892558383fc0" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_e5f72572-465e-46f0-b37d-32f2a62a12b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_4644672f-b9f6-4d53-8e9c-e8f66d10fb18" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_166b6d95-3e72-4c2f-8fd0-892558383fc0" xlink:to="loc_us-gaap_InventoryNet_4644672f-b9f6-4d53-8e9c-e8f66d10fb18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_7e135a37-d9f0-4be7-a6a0-eb34965b4268" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_166b6d95-3e72-4c2f-8fd0-892558383fc0" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_7e135a37-d9f0-4be7-a6a0-eb34965b4268" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_26f57d65-4a98-4f44-b794-379c51a461e9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_AssetsCurrent_26f57d65-4a98-4f44-b794-379c51a461e9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_b646d8c3-62ae-416b-a861-eb50c321d44a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_b646d8c3-62ae-416b-a861-eb50c321d44a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4c2ef07a-dc36-4ce4-b016-86083b539350" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4c2ef07a-dc36-4ce4-b016-86083b539350" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_31d1a3b4-177f-48e7-a3c8-86a25ec6c488" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_Goodwill_31d1a3b4-177f-48e7-a3c8-86a25ec6c488" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_8816659d-0580-4b20-b1f0-105b07f77e95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_8816659d-0580-4b20-b1f0-105b07f77e95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_25745a27-cd1e-450e-a88b-8f4b23f7ecb3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_fe567d50-551d-430d-b86b-5e269499d527" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_25745a27-cd1e-450e-a88b-8f4b23f7ecb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_36fbc956-8c87-412d-87ce-d8d5fe2642ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_829613c3-2a65-4a70-9788-2ff6d6b8faf2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_36fbc956-8c87-412d-87ce-d8d5fe2642ab" xlink:to="loc_us-gaap_LiabilitiesCurrent_829613c3-2a65-4a70-9788-2ff6d6b8faf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_a78e20f8-18c8-4ae1-ba91-22b6ff378e0f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_36fbc956-8c87-412d-87ce-d8d5fe2642ab" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_a78e20f8-18c8-4ae1-ba91-22b6ff378e0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_8c7d68d6-04d9-48af-955d-89babdf86548" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_36fbc956-8c87-412d-87ce-d8d5fe2642ab" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_8c7d68d6-04d9-48af-955d-89babdf86548" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_d2015466-34a3-4d06-ac0f-399a5d77921b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_36fbc956-8c87-412d-87ce-d8d5fe2642ab" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_d2015466-34a3-4d06-ac0f-399a5d77921b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d5c7b5-fecf-4cc8-87f2-88cc12a2fd93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_15ae4708-d031-497c-ba67-ac3b9b0f64f9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d5c7b5-fecf-4cc8-87f2-88cc12a2fd93" xlink:to="loc_us-gaap_Liabilities_15ae4708-d031-497c-ba67-ac3b9b0f64f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8e9f749a-f577-45bb-8499-0c9da0aafe41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e2d5c7b5-fecf-4cc8-87f2-88cc12a2fd93" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_8e9f749a-f577-45bb-8499-0c9da0aafe41" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_1cd72e24-e6ba-4cf6-952d-2c7b85ba8fbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_1cd72e24-e6ba-4cf6-952d-2c7b85ba8fbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_62263d68-4ac9-4404-91aa-1795cf368a85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:to="loc_us-gaap_ShortTermBorrowings_62263d68-4ac9-4404-91aa-1795cf368a85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_e7c04b7c-ef73-4bd6-8fae-869d9fa7f24f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_e7c04b7c-ef73-4bd6-8fae-869d9fa7f24f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_7b4262d9-5c5f-419a-9e73-86767c487c8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:to="loc_us-gaap_LongTermDebtCurrent_7b4262d9-5c5f-419a-9e73-86767c487c8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_2ed77e9c-46f1-4398-957c-bc5e70dcfc08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_f8e695f3-2383-4571-affb-c96180f23f5a" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_2ed77e9c-46f1-4398-957c-bc5e70dcfc08" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="vtrs-20211231.xsd#ConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/ConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3996dd8e-6f52-4d5a-ad5e-27f11d32b972" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_174dcc44-3034-4cec-abcb-e88b71d58dc8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3996dd8e-6f52-4d5a-ad5e-27f11d32b972" xlink:to="loc_us-gaap_OperatingIncomeLoss_174dcc44-3034-4cec-abcb-e88b71d58dc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_3ba61747-a7ff-42c0-a395-dfa22bf3d1e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3996dd8e-6f52-4d5a-ad5e-27f11d32b972" xlink:to="loc_us-gaap_InterestExpense_3ba61747-a7ff-42c0-a395-dfa22bf3d1e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_caf5425f-6312-4a9c-a0f9-11bfccfbf5ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_3996dd8e-6f52-4d5a-ad5e-27f11d32b972" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_caf5425f-6312-4a9c-a0f9-11bfccfbf5ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_bedb0c93-47ab-487a-b0bc-7e4b40d0ce34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_45fb6e04-913b-4a75-907c-fcc2ccfebbd4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_bedb0c93-47ab-487a-b0bc-7e4b40d0ce34" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_45fb6e04-913b-4a75-907c-fcc2ccfebbd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4fd9007d-fe23-4d77-93d4-9a00300a964b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_bedb0c93-47ab-487a-b0bc-7e4b40d0ce34" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4fd9007d-fe23-4d77-93d4-9a00300a964b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_5e238301-e244-42e6-83dc-03ad92798a43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_34439413-96bb-4a0a-a46a-1fb935156f71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5e238301-e244-42e6-83dc-03ad92798a43" xlink:to="loc_us-gaap_Revenues_34439413-96bb-4a0a-a46a-1fb935156f71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_f823c1bd-ffc9-4bea-a7df-4c9490989c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_5e238301-e244-42e6-83dc-03ad92798a43" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_f823c1bd-ffc9-4bea-a7df-4c9490989c6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_19e08480-ce92-4948-8ec1-6f2cd7e72d16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_5509c513-e182-4fcb-843a-0d5aefa435de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_19e08480-ce92-4948-8ec1-6f2cd7e72d16" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_5509c513-e182-4fcb-843a-0d5aefa435de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_31838d5f-1569-4e0c-84dd-a5567925c92c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_19e08480-ce92-4948-8ec1-6f2cd7e72d16" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_31838d5f-1569-4e0c-84dd-a5567925c92c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossRelatedToLitigationSettlement_60d84c00-6b2c-4090-a4de-29f6ac94d649" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossRelatedToLitigationSettlement"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_19e08480-ce92-4948-8ec1-6f2cd7e72d16" xlink:to="loc_us-gaap_GainLossRelatedToLitigationSettlement_60d84c00-6b2c-4090-a4de-29f6ac94d649" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_c10bb364-124e-4481-8238-ad6991d30799" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_56bc421b-963f-4775-9ebd-3fa5d3d09586" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_c10bb364-124e-4481-8238-ad6991d30799" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_56bc421b-963f-4775-9ebd-3fa5d3d09586" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b05358b7-3771-47c4-a4a7-4098e568cff7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_c10bb364-124e-4481-8238-ad6991d30799" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_b05358b7-3771-47c4-a4a7-4098e568cff7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_d8a5cb31-31ae-46ef-877c-d944e0c5de98" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_a6dfded3-159a-4dd5-9463-0bdc14eee908" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_d8a5cb31-31ae-46ef-877c-d944e0c5de98" xlink:to="loc_us-gaap_GrossProfit_a6dfded3-159a-4dd5-9463-0bdc14eee908" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_29a3230f-ae81-4d24-96a9-d31d34996af4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_d8a5cb31-31ae-46ef-877c-d944e0c5de98" xlink:to="loc_us-gaap_OperatingExpenses_29a3230f-ae81-4d24-96a9-d31d34996af4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ConsolidatedStatementsofComprehensiveEarnings" xlink:type="simple" xlink:href="vtrs-20211231.xsd#ConsolidatedStatementsofComprehensiveEarnings"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/ConsolidatedStatementsofComprehensiveEarnings" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_61401122-e91a-40c9-812d-62dcfc14eb6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_c1bfe8bd-f6b9-442a-8bc7-c2970790b86e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_61401122-e91a-40c9-812d-62dcfc14eb6a" xlink:to="loc_us-gaap_ProfitLoss_c1bfe8bd-f6b9-442a-8bc7-c2970790b86e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_592a26a9-3b31-4199-a6a5-b64ee75105de" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest_61401122-e91a-40c9-812d-62dcfc14eb6a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_592a26a9-3b31-4199-a6a5-b64ee75105de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_e5dcde2b-d08e-4f2e-a759-8783c5a56b55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_27f7f202-ea9e-48f7-8bc4-44a6629cd56d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_e5dcde2b-d08e-4f2e-a759-8783c5a56b55" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_27f7f202-ea9e-48f7-8bc4-44a6629cd56d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_8732e199-795e-486d-88c7-7a67539ffa8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_e5dcde2b-d08e-4f2e-a759-8783c5a56b55" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_8732e199-795e-486d-88c7-7a67539ffa8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_21e01d0b-f553-4e27-8251-6e06f8997b19" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_e5dcde2b-d08e-4f2e-a759-8783c5a56b55" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeTax_21e01d0b-f553-4e27-8251-6e06f8997b19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_2bd88faf-c440-419c-8b2a-51483b465705" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_e5dcde2b-d08e-4f2e-a759-8783c5a56b55" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAndTax_2bd88faf-c440-419c-8b2a-51483b465705" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_93fc03cb-fc96-4b6d-8a5f-7786bc1af821" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_2f7eff9f-8a7c-441a-b8cd-71f644e26259" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_93fc03cb-fc96-4b6d-8a5f-7786bc1af821" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_2f7eff9f-8a7c-441a-b8cd-71f644e26259" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_5485d630-1391-4a01-b5df-b71cf07662f4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_93fc03cb-fc96-4b6d-8a5f-7786bc1af821" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_5485d630-1391-4a01-b5df-b71cf07662f4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="vtrs-20211231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_0003d039-2848-4286-a21c-150d429b284c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_0003d039-2848-4286-a21c-150d429b284c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_fcc3dc01-e8c3-4cc3-a1ac-32f265157736" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_fcc3dc01-e8c3-4cc3-a1ac-32f265157736" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_28a5534b-a457-44a5-b1a7-a50d2e74c38d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_28a5534b-a457-44a5-b1a7-a50d2e74c38d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_db246158-678e-4275-83b0-886233da4335" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfShortTermDebt_db246158-678e-4275-83b0-886233da4335" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_f447bf42-e631-498e-bc18-402eff194f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_f447bf42-e631-498e-bc18-402eff194f8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3a505a1b-0207-4022-bb60-7a283e11a07d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3a505a1b-0207-4022-bb60-7a283e11a07d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_b09100e1-8a4e-467b-91e3-39bae5f4d6da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_b09100e1-8a4e-467b-91e3-39bae5f4d6da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_697e50ae-63c2-4b7d-a104-f7c8cc952a34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_697e50ae-63c2-4b7d-a104-f7c8cc952a34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_2d344076-5b88-4dde-9824-fc81463c2fbf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_2d344076-5b88-4dde-9824-fc81463c2fbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_PaymentsForNonContingentConsiderationForProductRightsFinancingActivities_bdd26385-402b-4069-9e77-381a46a31e5b" xlink:href="vtrs-20211231.xsd#vtrs_PaymentsForNonContingentConsiderationForProductRightsFinancingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_285077a9-2d02-46e5-9c49-58f4f710b81d" xlink:to="loc_vtrs_PaymentsForNonContingentConsiderationForProductRightsFinancingActivities_bdd26385-402b-4069-9e77-381a46a31e5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_71022310-ff7e-479e-89f0-641b4ae904cd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_ProfitLoss_71022310-ff7e-479e-89f0-641b4ae904cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_b464e74c-e353-4561-9a3b-deedfa086aa6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_b464e74c-e353-4561-9a3b-deedfa086aa6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2bc5c154-3bd1-4691-8e80-53d847e75784" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_2bc5c154-3bd1-4691-8e80-53d847e75784" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Changeinnoncashlitigationsettlementsnet_74170b9e-6e09-471a-a101-221cd7d32ac1" xlink:href="vtrs-20211231.xsd#vtrs_Changeinnoncashlitigationsettlementsnet"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_vtrs_Changeinnoncashlitigationsettlementsnet_74170b9e-6e09-471a-a101-221cd7d32ac1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_92073d6b-4504-4979-a29d-3a83acab30ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_92073d6b-4504-4979-a29d-3a83acab30ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_25a15b97-4c92-4878-ab40-42ce4716c1fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_ShareBasedCompensation_25a15b97-4c92-4878-ab40-42ce4716c1fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_093de3f3-d44b-4bc0-b462-bd5063a86d44" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WriteOffOfDeferredDebtIssuanceCost"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_WriteOffOfDeferredDebtIssuanceCost_093de3f3-d44b-4bc0-b462-bd5063a86d44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_48e16f0f-bd0b-4ce1-9fae-309c74df6d67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_48e16f0f-bd0b-4ce1-9fae-309c74df6d67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_16231f2a-6678-4217-ad8f-f98d84eabdf2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_16231f2a-6678-4217-ad8f-f98d84eabdf2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_b6afd314-d5f8-41b8-8ccc-b291425d9f7a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_b6afd314-d5f8-41b8-8ccc-b291425d9f7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_5e459f39-e018-4e05-ac58-9069d70ec913" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_5e459f39-e018-4e05-ac58-9069d70ec913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_f19c492b-e643-4d34-93b5-40ddc94a8c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_f19c492b-e643-4d34-93b5-40ddc94a8c1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_3be74902-9884-4af4-a8b9-dcbd7dd4d407" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_722ff9b1-9c72-42dc-b65b-4960f5fe63df" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_3be74902-9884-4af4-a8b9-dcbd7dd4d407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_412f407e-047a-476c-a042-8200bd3cf4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_527450f3-31d9-4546-ba44-62ddad5d05c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_412f407e-047a-476c-a042-8200bd3cf4bd" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_527450f3-31d9-4546-ba44-62ddad5d05c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_774476c4-f4d8-46bc-b4d3-d1121da2284a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_412f407e-047a-476c-a042-8200bd3cf4bd" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_774476c4-f4d8-46bc-b4d3-d1121da2284a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f5aafa48-f241-4c5d-96f5-f4759fbfd8e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_412f407e-047a-476c-a042-8200bd3cf4bd" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f5aafa48-f241-4c5d-96f5-f4759fbfd8e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8f8210e1-072c-4236-90b0-e035c51393ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_412f407e-047a-476c-a042-8200bd3cf4bd" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8f8210e1-072c-4236-90b0-e035c51393ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_612ff0df-4a3b-49d1-8f0b-a100fa7ed52b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_612ff0df-4a3b-49d1-8f0b-a100fa7ed52b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a2ce8293-5021-4a3b-92ab-5c088a5b4936" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a2ce8293-5021-4a3b-92ab-5c088a5b4936" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_335b0953-42fe-4acd-9cab-dbfd48cc933a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_335b0953-42fe-4acd-9cab-dbfd48cc933a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_c100be43-285b-4040-9f9a-4cf27e18fcf8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromDivestitureOfBusinesses"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_ProceedsFromDivestitureOfBusinesses_c100be43-285b-4040-9f9a-4cf27e18fcf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_823a869d-439f-4481-b29f-fefa158078f3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_823a869d-439f-4481-b29f-fefa158078f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_273af95a-66ab-4012-b09d-cd199023dfe6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_273af95a-66ab-4012-b09d-cd199023dfe6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_40456c81-518a-49cb-9ca8-4363c9bb83cc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_289243b6-8fe0-498d-9932-65621499d8fe" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_40456c81-518a-49cb-9ca8-4363c9bb83cc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/SummaryofSignificantAccountingPoliciesBasicAndDilutedEarningsPerOrdinaryShareAttributableToMylanNVDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#SummaryofSignificantAccountingPoliciesBasicAndDilutedEarningsPerOrdinaryShareAttributableToMylanNVDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/SummaryofSignificantAccountingPoliciesBasicAndDilutedEarningsPerOrdinaryShareAttributableToMylanNVDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ce6cffab-2d1d-4479-9b1e-b7e2748f19ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_de00f805-f183-4b5a-a9af-bf156ad747d0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ce6cffab-2d1d-4479-9b1e-b7e2748f19ce" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_de00f805-f183-4b5a-a9af-bf156ad747d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_a85e2b75-ff6a-4709-9553-f16797177759" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ce6cffab-2d1d-4479-9b1e-b7e2748f19ce" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_a85e2b75-ff6a-4709-9553-f16797177759" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#RevenueRecognitionandAccountsReceivableVariableConsiderationDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableVariableConsiderationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_SalesRevenueGrosstonetadjustments_407b0905-9c2c-4af6-9d81-e22ea399f405" xlink:href="vtrs-20211231.xsd#vtrs_SalesRevenueGrosstonetadjustments"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Chargebacks_07d40cca-5318-4fd2-ab49-ddd7163d34ae" xlink:href="vtrs-20211231.xsd#vtrs_Chargebacks"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_407b0905-9c2c-4af6-9d81-e22ea399f405" xlink:to="loc_vtrs_Chargebacks_07d40cca-5318-4fd2-ab49-ddd7163d34ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AccruedSalesAllowances_fe177136-5d6b-4f99-8c26-bfa0eccea3e1" xlink:href="vtrs-20211231.xsd#vtrs_AccruedSalesAllowances"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_407b0905-9c2c-4af6-9d81-e22ea399f405" xlink:to="loc_vtrs_AccruedSalesAllowances_fe177136-5d6b-4f99-8c26-bfa0eccea3e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_RevenuefromContractwithCustomerReturns_6d12077e-7582-4806-88a1-3c22253ce942" xlink:href="vtrs-20211231.xsd#vtrs_RevenuefromContractwithCustomerReturns"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_407b0905-9c2c-4af6-9d81-e22ea399f405" xlink:to="loc_vtrs_RevenuefromContractwithCustomerReturns_6d12077e-7582-4806-88a1-3c22253ce942" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Medicaidandothergovernmentalrebates_27d4be01-ee28-4916-b332-557499e496a7" xlink:href="vtrs-20211231.xsd#vtrs_Medicaidandothergovernmentalrebates"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_SalesRevenueGrosstonetadjustments_407b0905-9c2c-4af6-9d81-e22ea399f405" xlink:to="loc_vtrs_Medicaidandothergovernmentalrebates_27d4be01-ee28-4916-b332-557499e496a7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/RevenueRecognitionandAccountsReceivableAccountsReceivableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_996ccd4e-693f-4ebc-900a-1694e9ef1075" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_cf8abae7-6c35-482c-b8dd-ffaeeefadbba" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_996ccd4e-693f-4ebc-900a-1694e9ef1075" xlink:to="loc_us-gaap_ReceivablesNetCurrent_cf8abae7-6c35-482c-b8dd-ffaeeefadbba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_a4f4f519-1a37-4aad-9f87-31b6ae84996f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsReceivableNetCurrent_996ccd4e-693f-4ebc-900a-1694e9ef1075" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_a4f4f519-1a37-4aad-9f87-31b6ae84996f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsBalanceSheetComponentsCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsBalanceSheetComponentsCashandCashEquivalentsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsBalanceSheetComponentsCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ecc01bc6-d4bd-4adc-b084-f7b8d3d60181" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f964250d-cfe3-4adf-beb0-3e5dcdd096fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ecc01bc6-d4bd-4adc-b084-f7b8d3d60181" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f964250d-cfe3-4adf-beb0-3e5dcdd096fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_a5c7f54b-4683-4dca-9400-92d1def18be2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ecc01bc6-d4bd-4adc-b084-f7b8d3d60181" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_a5c7f54b-4683-4dca-9400-92d1def18be2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_20a336f4-fded-46bb-aebb-f301c5387b7e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_3f3c72ed-5a35-4910-b566-7e31d0dbb990" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_20a336f4-fded-46bb-aebb-f301c5387b7e" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_3f3c72ed-5a35-4910-b566-7e31d0dbb990" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_061d63a5-9bdc-4197-9df6-f54b204ba726" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_20a336f4-fded-46bb-aebb-f301c5387b7e" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_061d63a5-9bdc-4197-9df6-f54b204ba726" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_c776f767-3827-4584-9558-d6ea8a0ccea5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_20a336f4-fded-46bb-aebb-f301c5387b7e" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_c776f767-3827-4584-9558-d6ea8a0ccea5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPrepaidsandothercurrentassetsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsPrepaidsandothercurrentassetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPrepaidsandothercurrentassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_e680bc91-3a05-4c68-9bc4-c599f6b82bcd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_e680bc91-3a05-4c68-9bc4-c599f6b82bcd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_42a24b58-004e-4e1e-8532-fe6273cd90e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_42a24b58-004e-4e1e-8532-fe6273cd90e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_a7831b95-6b63-4df1-ac6d-f1ddc84683b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_a7831b95-6b63-4df1-ac6d-f1ddc84683b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_7ecaa646-02a3-41f2-8957-359a6ecbb92a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_7ecaa646-02a3-41f2-8957-359a6ecbb92a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_12e739de-dd82-450c-b3d9-69ff2e0edb14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a8133664-cc87-44f6-9cd9-5d821f6af411" xlink:to="loc_us-gaap_OtherAssetsCurrent_12e739de-dd82-450c-b3d9-69ff2e0edb14" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_6cf44ca6-ed10-46a3-a1c1-61a3a6ef0575" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_44c110d0-9f8a-4a1d-aa6e-d0f02c229ac2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_6cf44ca6-ed10-46a3-a1c1-61a3a6ef0575" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_44c110d0-9f8a-4a1d-aa6e-d0f02c229ac2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_a3986182-8e81-465f-9c85-cd0c16ffd0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_6cf44ca6-ed10-46a3-a1c1-61a3a6ef0575" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_a3986182-8e81-465f-9c85-cd0c16ffd0a9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsOtherAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_a5e762a0-5531-48ea-818c-d3975f12dc34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_0db410fd-5a25-465f-b826-c73020aaef96" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_a5e762a0-5531-48ea-818c-d3975f12dc34" xlink:to="loc_us-gaap_EquityMethodInvestments_0db410fd-5a25-465f-b826-c73020aaef96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Otherlongtermassets_8dd53d88-3c28-40a7-a05c-edd1c63c3f39" xlink:href="vtrs-20211231.xsd#vtrs_Otherlongtermassets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsNoncurrent_a5e762a0-5531-48ea-818c-d3975f12dc34" xlink:to="loc_vtrs_Otherlongtermassets_8dd53d88-3c28-40a7-a05c-edd1c63c3f39" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#BalanceSheetComponentsTradeAccountsPayableDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/BalanceSheetComponentsTradeAccountsPayableDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_558a4d03-2a24-49ca-b08d-cf9f50506b37" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_46147e39-5b7b-4d0f-b3aa-bc4230d268dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableTradeCurrentAndNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_558a4d03-2a24-49ca-b08d-cf9f50506b37" xlink:to="loc_us-gaap_AccountsPayableTradeCurrentAndNoncurrent_46147e39-5b7b-4d0f-b3aa-bc4230d268dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_a612da9c-5ff0-4b6e-8904-66db8315ce2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableOtherCurrentAndNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableTradeCurrent_558a4d03-2a24-49ca-b08d-cf9f50506b37" xlink:to="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_a612da9c-5ff0-4b6e-8904-66db8315ce2c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LeasesLeaseMaturitiesDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#LeasesLeaseMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/LeasesLeaseMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_6c4b7449-889c-42b2-a2dd-ba711d886bf6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_6c4b7449-889c-42b2-a2dd-ba711d886bf6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_7c71faf5-9d12-4e99-a9c2-e58d9558eb0b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_7c71faf5-9d12-4e99-a9c2-e58d9558eb0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_c4724679-15f1-4cf4-a16a-d629c51b3e12" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_c4724679-15f1-4cf4-a16a-d629c51b3e12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_7b370deb-fbb1-446a-b185-35e3e76c34ea" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_7b370deb-fbb1-446a-b185-35e3e76c34ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_686e6f53-b3a6-4095-a906-909be533049d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_686e6f53-b3a6-4095-a906-909be533049d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_ad1416d1-c066-496b-9ba7-48bd947289ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_20d87a99-dae8-45d6-a61c-2364f71a5229" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_ad1416d1-c066-496b-9ba7-48bd947289ad" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/LeasesLeaseMaturitiesDetails_1" xlink:type="simple" xlink:href="vtrs-20211231.xsd#LeasesLeaseMaturitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/LeasesLeaseMaturitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8b819206-c0c1-44e4-8e0b-3694bcdb61b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_36e1b56a-cbd8-4c96-a2f5-2688acd87f1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8b819206-c0c1-44e4-8e0b-3694bcdb61b4" xlink:to="loc_us-gaap_OperatingLeaseLiability_36e1b56a-cbd8-4c96-a2f5-2688acd87f1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_5902c380-ba13-414a-a5ca-d81f795b453f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8b819206-c0c1-44e4-8e0b-3694bcdb61b4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_5902c380-ba13-414a-a5ca-d81f795b453f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/GoodwillandOtherIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#GoodwillandOtherIntangibleAssetsComponentsofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/GoodwillandOtherIntangibleAssetsComponentsofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_2debd07b-1d13-4675-825f-0dba8d2f0d41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5ab8be3b-035c-492a-b2f9-2ed2472da2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_2debd07b-1d13-4675-825f-0dba8d2f0d41" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5ab8be3b-035c-492a-b2f9-2ed2472da2f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_df7ef48f-6f73-41b0-b236-bef9b44ffbdb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_2debd07b-1d13-4675-825f-0dba8d2f0d41" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_df7ef48f-6f73-41b0-b236-bef9b44ffbdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1d09a497-09a3-46d2-8a8a-b9758d5540ec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_87db68a4-21b9-4ce6-a7a5-4fbc94744f71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1d09a497-09a3-46d2-8a8a-b9758d5540ec" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_87db68a4-21b9-4ce6-a7a5-4fbc94744f71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_909eaccb-4c06-488c-88ef-243af2ae9b55" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_1d09a497-09a3-46d2-8a8a-b9758d5540ec" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_909eaccb-4c06-488c-88ef-243af2ae9b55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_37ab47e9-c77a-41bd-9fa1-3e53bfa6a810" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_b2dfed16-741f-4955-bee7-fe15ab5b4211" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_37ab47e9-c77a-41bd-9fa1-3e53bfa6a810" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_b2dfed16-741f-4955-bee7-fe15ab5b4211" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d27863ae-582d-401d-8e97-121b07cdc117" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_37ab47e9-c77a-41bd-9fa1-3e53bfa6a810" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d27863ae-582d-401d-8e97-121b07cdc117" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementScheduleofAvailableforsaleSecuritiesReconciliationDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#FinancialInstrumentsandRiskManagementScheduleofAvailableforsaleSecuritiesReconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementScheduleofAvailableforsaleSecuritiesReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_90722c92-73ba-4167-afd5-60c3f970f7e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_7377fe22-3812-4a32-9756-7ef2b7185249" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_90722c92-73ba-4167-afd5-60c3f970f7e7" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_7377fe22-3812-4a32-9756-7ef2b7185249" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1d7e8fe6-1e0d-437a-85cd-53aacf3d1484" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_90722c92-73ba-4167-afd5-60c3f970f7e7" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1d7e8fe6-1e0d-437a-85cd-53aacf3d1484" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9b1630d6-5a33-4adc-b55c-b5e704734a09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_90722c92-73ba-4167-afd5-60c3f970f7e7" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9b1630d6-5a33-4adc-b55c-b5e704734a09" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementMaturitiesofAvailableforsaleDebtSecuritiesatFairValueDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#FinancialInstrumentsandRiskManagementMaturitiesofAvailableforsaleDebtSecuritiesatFairValueDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/FinancialInstrumentsandRiskManagementMaturitiesofAvailableforsaleDebtSecuritiesatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_eab1dc1c-f623-4cbf-ae82-f45aef501b42" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveYearsAndLaterFairValue_e935e29a-044a-4a27-b749-716fba814fcb" xlink:href="vtrs-20211231.xsd#vtrs_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveYearsAndLaterFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_eab1dc1c-f623-4cbf-ae82-f45aef501b42" xlink:to="loc_vtrs_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveYearsAndLaterFairValue_e935e29a-044a-4a27-b749-716fba814fcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_ed7253ed-8c87-4e04-a4b8-7c0ed66a8a5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_eab1dc1c-f623-4cbf-ae82-f45aef501b42" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_ed7253ed-8c87-4e04-a4b8-7c0ed66a8a5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_283816ba-c95e-43a7-ad05-123766eec28a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_eab1dc1c-f623-4cbf-ae82-f45aef501b42" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_283816ba-c95e-43a7-ad05-123766eec28a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#DebtMinimumRepaymentsonOutstandingBorrowingsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/DebtMinimumRepaymentsonOutstandingBorrowingsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_6f1c8826-cbf4-4531-b0d9-b363c8adcb1b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_6f1c8826-cbf4-4531-b0d9-b363c8adcb1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_65cfbf08-1257-4deb-a4d0-a57df624c679" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_65cfbf08-1257-4deb-a4d0-a57df624c679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_f812666c-bbda-4ace-aa83-f1acb00ea82a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_f812666c-bbda-4ace-aa83-f1acb00ea82a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_b4714b30-5295-4754-8cf2-10ecba30ad90" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_b4714b30-5295-4754-8cf2-10ecba30ad90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_253cad9d-1c38-4eab-8afe-1e97587b6df8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_253cad9d-1c38-4eab-8afe-1e97587b6df8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_30d9faf4-c865-4fe0-9950-413f3ef72ee5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_490610e8-07df-4568-a7a7-75ede135f8c1" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_30d9faf4-c865-4fe0-9950-413f3ef72ee5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxProvisionDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#IncomeTaxesScheduleofComponentsofIncomeTaxProvisionDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/IncomeTaxesScheduleofComponentsofIncomeTaxProvisionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_9676cf43-0646-46c3-b770-5d1aca4034d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_81126f2d-8b42-4aa7-a7ac-c27aaa350c6b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_9676cf43-0646-46c3-b770-5d1aca4034d3" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_81126f2d-8b42-4aa7-a7ac-c27aaa350c6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_f8214438-f900-4209-af6a-103381c5226c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ForeignIncomeTaxExpenseBenefitContinuingOperations_9676cf43-0646-46c3-b770-5d1aca4034d3" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_f8214438-f900-4209-af6a-103381c5226c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_d8ae79fe-f46e-4763-bdf3-8dd796f309db" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_33c3c0c4-5fd3-4aa8-a1d3-1cf13f3837c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_d8ae79fe-f46e-4763-bdf3-8dd796f309db" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_33c3c0c4-5fd3-4aa8-a1d3-1cf13f3837c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_35887a76-60a1-4a68-b998-d7061b236935" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FederalIncomeTaxExpenseBenefitContinuingOperations_d8ae79fe-f46e-4763-bdf3-8dd796f309db" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_35887a76-60a1-4a68-b998-d7061b236935" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_19c7af75-8c6c-4022-bbcb-6fb21d4288f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_7bf2627c-3b56-4919-b63c-aae907a08308" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_19c7af75-8c6c-4022-bbcb-6fb21d4288f5" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_7bf2627c-3b56-4919-b63c-aae907a08308" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_7ee8634d-596c-43c0-bd2c-8a6402c76669" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StateAndLocalIncomeTaxExpenseBenefitContinuingOperations_19c7af75-8c6c-4022-bbcb-6fb21d4288f5" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_7ee8634d-596c-43c0-bd2c-8a6402c76669" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/IncomeTaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_1abf8cf4-4e9a-406e-b24b-a4b04fdb0080" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_1abf8cf4-4e9a-406e-b24b-a4b04fdb0080" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DeferredTaxAssetsIntangibleAssets_271e6498-0edb-4c84-8090-25cdfb0d79ba" xlink:href="vtrs-20211231.xsd#vtrs_DeferredTaxAssetsIntangibleAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_vtrs_DeferredTaxAssetsIntangibleAssets_271e6498-0edb-4c84-8090-25cdfb0d79ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits_2deade67-a83a-4b07-a2bd-251af3d5f4a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits_2deade67-a83a-4b07-a2bd-251af3d5f4a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_74aaabe5-cd44-4136-b0bb-d6a9de86720f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_74aaabe5-cd44-4136-b0bb-d6a9de86720f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_d387dcaa-94e0-4d80-8af3-b18e1585c017" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_d387dcaa-94e0-4d80-8af3-b18e1585c017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies_d3708298-4cdc-4c73-8189-8268c75ee29e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsContingencies_d3708298-4cdc-4c73-8189-8268c75ee29e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsInventory_d2f0f805-9b7e-43be-897e-fab7853d8635" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsInventory"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_us-gaap_DeferredTaxAssetsInventory_d2f0f805-9b7e-43be-897e-fab7853d8635" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DeferredTaxAssetsOperatingLeaseRightofUseAssets_cb82dc95-af1b-42f5-b43a-32b22c865873" xlink:href="vtrs-20211231.xsd#vtrs_DeferredTaxAssetsOperatingLeaseRightofUseAssets"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_vtrs_DeferredTaxAssetsOperatingLeaseRightofUseAssets_cb82dc95-af1b-42f5-b43a-32b22c865873" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DeferredTaxAssetsDeferredtaxexpenseinterestexpense_ace0d2c0-b05d-44e4-9d66-6490b0742af9" xlink:href="vtrs-20211231.xsd#vtrs_DeferredTaxAssetsDeferredtaxexpenseinterestexpense"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_d2e49a45-d236-4e39-ba5b-3ed537743f02" xlink:to="loc_vtrs_DeferredTaxAssetsDeferredtaxexpenseinterestexpense_ace0d2c0-b05d-44e4-9d66-6490b0742af9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilities_56654668-2f16-457a-a723-896fa8de28b9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_c535710e-080d-424d-91e1-cfbc1f53c0aa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_56654668-2f16-457a-a723-896fa8de28b9" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_c535710e-080d-424d-91e1-cfbc1f53c0aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_a86e882e-19ac-4294-b9fe-f790be9b5d76" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_56654668-2f16-457a-a723-896fa8de28b9" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_a86e882e-19ac-4294-b9fe-f790be9b5d76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_91cefe69-454d-474c-a9b6-8fa7cb587ace" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_883673a1-4498-4dbd-b844-49b2c85f8c16" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_91cefe69-454d-474c-a9b6-8fa7cb587ace" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_883673a1-4498-4dbd-b844-49b2c85f8c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_DeferredTaxLiabilitiesOperatingLeaseLiability_cca684c3-716e-4e8e-869e-043d72902c81" xlink:href="vtrs-20211231.xsd#vtrs_DeferredTaxLiabilitiesOperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_91cefe69-454d-474c-a9b6-8fa7cb587ace" xlink:to="loc_vtrs_DeferredTaxLiabilitiesOperatingLeaseLiability_cca684c3-716e-4e8e-869e-043d72902c81" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_5a1fcaf8-e148-4aee-9d6b-4e2ed1a6e7ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_91cefe69-454d-474c-a9b6-8fa7cb587ace" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_5a1fcaf8-e148-4aee-9d6b-4e2ed1a6e7ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_a12710c0-7344-42c0-9c87-51346e33b0c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_91cefe69-454d-474c-a9b6-8fa7cb587ace" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_a12710c0-7344-42c0-9c87-51346e33b0c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_1e843136-74f7-4f1f-aa36-2421edba8e4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_8249ebca-db14-4b95-9af4-fd10bb9c7762" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_1e843136-74f7-4f1f-aa36-2421edba8e4c" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_8249ebca-db14-4b95-9af4-fd10bb9c7762" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_34a47303-0519-4ee5-b4ae-ac4e6b8eabc5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_1e843136-74f7-4f1f-aa36-2421edba8e4c" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_34a47303-0519-4ee5-b4ae-ac4e6b8eabc5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EmployeeBenefitPlansAccumulatedOtherComprehensiveIncomeLossPretaxAmountsNotYetReclassifiedinNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#EmployeeBenefitPlansAccumulatedOtherComprehensiveIncomeLossPretaxAmountsNotYetReclassifiedinNetPeriodicBenefitCostDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EmployeeBenefitPlansAccumulatedOtherComprehensiveIncomeLossPretaxAmountsNotYetReclassifiedinNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_6f8c45fe-2c28-4d14-a940-81973e94f145" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_aa872c75-c911-49fb-8c57-f07741376ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_6f8c45fe-2c28-4d14-a940-81973e94f145" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_aa872c75-c911-49fb-8c57-f07741376ec4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_593bceda-b18f-4fa4-ae5a-cd6e3fdf3c79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_6f8c45fe-2c28-4d14-a940-81973e94f145" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_593bceda-b18f-4fa4-ae5a-cd6e3fdf3c79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EmployeeBenefitPlansChangeinAccumulatedIncomeLossRelatingtoDefinedBenefitPensionandOtherPostretirementBenefitsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#EmployeeBenefitPlansChangeinAccumulatedIncomeLossRelatingtoDefinedBenefitPensionandOtherPostretirementBenefitsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EmployeeBenefitPlansChangeinAccumulatedIncomeLossRelatingtoDefinedBenefitPensionandOtherPostretirementBenefitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_6da068f8-9d68-4df3-a791-82eb12fb1386" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_6da068f8-9d68-4df3-a791-82eb12fb1386" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_ae48ec73-c120-43b9-b9de-2c2c3e7140ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_ae48ec73-c120-43b9-b9de-2c2c3e7140ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_e8f9d9da-b257-4cbc-af30-5ce6784cdf2f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:to="loc_us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_e8f9d9da-b257-4cbc-af30-5ce6784cdf2f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax_b7a517e5-d89e-44ad-aa13-cc5c430a4224" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax_b7a517e5-d89e-44ad-aa13-cc5c430a4224" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_OtherComprehensiveIncomeDefinedBenefitPlanForeignCurrencyTranslationBeforeTax_5a89cef1-50c1-4af1-b186-89f9740f06c0" xlink:href="vtrs-20211231.xsd#vtrs_OtherComprehensiveIncomeDefinedBenefitPlanForeignCurrencyTranslationBeforeTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_e45d5daf-7bf1-4a62-a42c-74edc1472032" xlink:to="loc_vtrs_OtherComprehensiveIncomeDefinedBenefitPlanForeignCurrencyTranslationBeforeTax_5a89cef1-50c1-4af1-b186-89f9740f06c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EmployeeBenefitPlansNetPeriodicBenefitCostsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#EmployeeBenefitPlansNetPeriodicBenefitCostsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EmployeeBenefitPlansNetPeriodicBenefitCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_30309c53-775e-45f0-96d0-9233f3cea213" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_30309c53-775e-45f0-96d0-9233f3cea213" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_3c1ef5cc-9d26-41c8-b2ca-8cafbc75b7c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_3c1ef5cc-9d26-41c8-b2ca-8cafbc75b7c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_86b9b92b-dc23-4249-a879-f88780f2e93c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_86b9b92b-dc23-4249-a879-f88780f2e93c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanCurtailments_c325e686-51d6-49ab-b79d-988214878769" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanCurtailments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_DefinedBenefitPlanCurtailments_c325e686-51d6-49ab-b79d-988214878769" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_ceac8b2a-7ad4-4f14-bb7f-0a9cad2c8a21" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_ceac8b2a-7ad4-4f14-bb7f-0a9cad2c8a21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_b6f27fb6-5509-4ee3-ad8e-c5e06db9819f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_55379aa1-cbda-4459-b355-b387808d1696" xlink:to="loc_us-gaap_DefinedBenefitPlanRecognizedNetGainLossDueToSettlements1_b6f27fb6-5509-4ee3-ad8e-c5e06db9819f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EmployeeBenefitPlansNetAccruedBenefitCostsClassificationonBalanceSheetDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#EmployeeBenefitPlansNetAccruedBenefitCostsClassificationonBalanceSheetDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EmployeeBenefitPlansNetAccruedBenefitCostsClassificationonBalanceSheetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_Netaccruedbenefitcosts_d001f9d5-ea3c-4679-8fdc-eecfd31ed986" xlink:href="vtrs-20211231.xsd#vtrs_Netaccruedbenefitcosts"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_1b76d841-7936-4a2c-92bb-7d74ed169d04" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_Netaccruedbenefitcosts_d001f9d5-ea3c-4679-8fdc-eecfd31ed986" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsForPlanBenefitsNoncurrent_1b76d841-7936-4a2c-92bb-7d74ed169d04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_ae1e9d78-5ce6-4aff-b027-6c475dc98e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_Netaccruedbenefitcosts_d001f9d5-ea3c-4679-8fdc-eecfd31ed986" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansCurrentLiabilities_ae1e9d78-5ce6-4aff-b027-6c475dc98e8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_2edabfd4-245a-4e1b-8a6c-a9df838c9b17" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_Netaccruedbenefitcosts_d001f9d5-ea3c-4679-8fdc-eecfd31ed986" xlink:to="loc_us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesNoncurrent_2edabfd4-245a-4e1b-8a6c-a9df838c9b17" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.viatris.com/role/EmployeeBenefitPlansEstimatedFutureBenefitPaymentsDetails" xlink:type="simple" xlink:href="vtrs-20211231.xsd#EmployeeBenefitPlansEstimatedFutureBenefitPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.viatris.com/role/EmployeeBenefitPlansEstimatedFutureBenefitPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:href="vtrs-20211231.xsd#vtrs_ExpectedFutureBenefitPayments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_0249e2f0-b0c3-4770-9206-9246f10dd177" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_0249e2f0-b0c3-4770-9206-9246f10dd177" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_78ab1ebc-a5cb-45f5-9a57-ada80aa1462d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_78ab1ebc-a5cb-45f5-9a57-ada80aa1462d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_9e667c8f-a516-4a56-a03a-905815178b9a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_9e667c8f-a516-4a56-a03a-905815178b9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_00f2b5d5-6d81-4ace-be29-da4f6d1fe34f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_00f2b5d5-6d81-4ace-be29-da4f6d1fe34f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_96bd8d58-e9d0-492d-b1e3-4ba3bf007950" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_96bd8d58-e9d0-492d-b1e3-4ba3bf007950" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_617008a9-f46c-45db-a758-0904f170121f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_vtrs_ExpectedFutureBenefitPayments_30ef42b5-c245-4278-bfbf-ce74784a6166" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_617008a9-f46c-45db-a758-0904f170121f" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
